Cystic Fibrosis Explored Explained Understood?
Medical Science allows us to understand the Human Body and its illnesses are all of Biological Creation - to which they have the scientific proof, do they not - thus we are obliged to accept these findings.
We all know the Human Body made mostly of water, which is a seriously precious commodity that life cannot exist without; so why waste it.
Of all the wonders of the Human Body one is more mysterious than any other... Yet still - according to Medical Science, does not even exist...
Let us explore the Mystery - called Cystic Fibrosis from the aspect of...!
One may term this - as hiding from the truth as we all appear to do, when mysterious illness strikes.
Like all illness; Cystic Fibrosis is only a name of a collective of symptoms given by those attempting to discover the true cause and how to create a cure - not an illness in itself.
This Paper is as much of what is reasonable to consider - as it is a matter of fact...
It is also combined information from Wikipedia and a number of professional sources.
Please accept this document is not in pursuit of a Literary or Grammatical Prize it is an expression and opinions of the understandings made by Medical Science and why at the beginning of the year 2017 - no illness has a cur, with words highlighted in different ways to accentuate the obvious and not so obvious.
Therefore, it may contain a number of repeats - giving rise to different opinions and or conflicting information; perhaps therefore, this particular medical and even perhaps complementary medical activity, demands such serious scrutiny.
Moreover, for a Medically qualified Person considered as. Anecdotal - a posh word for storytelling.
If in reading this paper - my opinions and writings appear to be like a foreign language or even rambling.
Consider reading this paper - not as a book; take some time to comprehend the contents.
Where I would like to think and feel sure, it will make sense?
So often, we read or hear in detail. "What" (description or symptoms) of an illness - but rarely if ever does anyone take the time, to truly explain...
"...WHY," or how Illness is really caused...
...this paper is designed to answer many of the questions - we are so often left with.
Where many times we have the questions and no answers - or the answers and not the questions.
If I have unwittingly left anything out or not satisfactorily answered, please email (address at the end of this page) and I will include it in this Paper at the earliest opportunity.
Please include item number or a copy and paste if possible - of the item that is not clear.
Did we not all struggle as a Child to learn many things we now through the experience of life - are now extremely competent with.
No apology if offered if discussions are repeated within this paper.
The understanding for this, nothing is more repeating than illness that is there every day of one's life and - despite treatments not only does not get better or have a satisfactory explanation/understanding.
More often becomes worse, as Medical Science continues to write Scientifically Proven Papers about illness; in a confusing, repeating strange to many language/words or descriptions - in a manner that confuses everyone and ultimately even themselves!
The first thing in the process of answering this is, for any one suffering illness, it is very clear...
"...New understandings are required about illness..."
Far too many times - I have heard from People...
..."If Doctors cannot Cure me how can a Person not medically qualified"...
...making it appear the existing quality medical education is the same worldwide..?
If on reading this or any of Talking Cures understanding of illness, one gets the impression...
....I am angry...
...then please believe it; because in late 2016. People are not only - not recovering from any illness, as so often the treatments make them worse and no one knows why or it appears. Cares.
One could also be forgiven for thinking I am against:
2. The Medical Profession.
3. Medical Scientists.
4. Medical Researchers.
5. Alternative Medicine.
6. Complimentary medicine.
8. Government policy.
The reality is I am a staunch supporter of any Person or Institution that helps People through tough Emotional and physical concerns.
I confess to being most seriously against Bad Medical Science that has never in real-terms once demonstrated the cause is truly known of any illness and as a result created a cure...
= ...no more illness and no more medications.
More importantly, I find it difficult to comprehend the Medicines created to treat any illness often has so many side effects and in some cases even causes symptoms the medicine was indeed prescribed to treat, indicating Doctors desire or ability of - being only in the "moment" to relieve the symptoms, is important.
Sadly - no real consideration is given to the long-term negative effects and often worsening of symptoms and most certainly no link between passed seemingly successfully treated symptoms and the present symptoms - is ever made.
From Talking Cures point of view and therapeutic practice - names of illness especially Medically Diagnosed recognised and Scientifically proven, are of no real value in the understanding and treatment of any illness - the only Name we should use or symptom we may label is...
"A Person is unable to achieve a Healthy and satisfactory lifestyle...”
...Or have never been allowed to become the Person they should have...
Thus requires. “Specialised assistance,” in order to make sense of the presenting symptoms, the cause and reason for them - enabling automatic resolution via the Persons own immune systems and Body replication process - referred to as, the Entire Body Chemistry; or BLOOD.
...Surely if a Person cannot be in control of self-repair - when can they be in control!
To a trained Medical Mind these questions and answer updates may well appear or feel patronising - it is hoped not, as their structure is at the very. "Heart" of the success of Talking Cures as a therapeutic application and may well be a serious asset and improvement in the successful outcomes of Medical Treatments.
In order to fully appreciate this, it is helpful to consider and accept;
All of the information as to why a Person became ill in the first place and as a consequence - all of the information required for them to automatically create immune response repair is - not only contained within the confines of their Mind - it is the only information required to bring about the required Automatic Cure using their own immune systems and Body replication processes. As designed by the Mind and Body.
By creating very cleverly constructed questions - Knowing the Person is able to answer them with their own knowledge of themselves of which they are a Master and if they are unable to - with my interpretations, accepted as re-education of their own information, that continues/completes on an on-going bases; the process either returning to well-health or well-health for the very first time in their lives.
Based on the secure knowledge...
"...The only Person with the Integrity and Wisdom to fully Understand their illness and its cause - is the Person themselves."
There are most serious considerations as to why this process as with all illness treatment interventions - appears not to succeed...
...when the Protection created in response to early Childhood Emotional and or Physical traumas is so great the Person is unable to see their Protection(s) and therefore unable to lower the Protection - allowing a Person to observe in a safe therapeutic environment the cause and consequences of such Protection, is the only safe way to resolve illness.
And. As a result, too gently - if one dare uses such words, lower the Protection, which will allow an immune response and an automatic alteration in ones thinking process, leading to a natural life - with comfort of Mind and Body...
...Always maintaining control of one's own Standards and Priorities and Code of Conduct.
A. Given the understanding you have no medical qualifications - are you able to explain how you can present this information regarding perhaps an illness you have no real prior knowledge of, in the way that you seem very able and comfortable with?
B. by what Standards and Priorities do you make such assertions and what Checks and Balances do you apply to demonstrate validity and you are not being Psychotic and therefore Delusional - in order to ensure you offer the best service possible?
Answer. 1: Good question and thank you.
A. First may we understand it is the ability to work - using only the Persons Mind, of which there is no known precedent with as many and constantly changing set of symptoms a Person is able to present; is at the very foundation from which I work.
1. Furthermore, one has to consider. If one does not know the cause of the illness within any given specialism following perhaps decades of study and still has no cures - is there a true benefit in being highly Medically Qualified and using Scientifically Proven Treatments.
B. My understanding and acceptance - everyone in the Medical Profession is doing the very best they are able with Management techniques, yet fail to truly comprehend the enormity of the constantly repeated statement. "Of the 100,000 illness recognised and diagnosed," still in early 2017 there is not one definitive cure for any illness.
C. Leaving me to conclude - does the world understand illness at all and do they understand therapy, no matter what banner it works under.
D. Thus I start from a piece of information where a Person - say on Face book or LinkedIn posts a question about an illness and collect from the available sources, as much information as I am able, regarding the latest information known about the illness.
E. I then create a new web page and copy and paste the information into the page.
F. From here, I start the edit process of this information - yet do not attempt to understand it, in much the same way a Person with the illness may in pursuit of answers and questions.
G. Part of the edit process is to convert words, that appear are used only to confuse - by researching many medical publications or dictionaries, into a readable format and many times providing the meaning of the word.
H. This sometimes proves to be quite a time consuming task.
I. Then I go through every word and edit out the grammatical parts that I feel could read better. IE. Don't - do not. Doesn't - does not or isn't - is not and at the same time apply reference numbers to each sentence as well as colour highlights of information I feel deserves such treatment.
1. I also omit or edit out the First Person use of the word, "you." As this is directive and suggestive - based on the belief only a Person ill will read the paper.
J. Finely - once the page is in a presentable format. I then start to comprehend the enormity of the message and make responses as required, ending with why Talking Cures feels or have proven if only to my own satisfaction, how the illness is caused.
K. Once the creation process is complete I use a number of ways to spell check the entire document - often confused by different ways of spelling the word from country to country.
L. Some forty to sixty hours later, or many more depending on the amount of information - having read the document more times than I am able to count.
Finely I check for best level of continuity.
1. From this point I take the decision it is ready to publish free of any sign up - no collection of saleable contact information or fees; for all to use at their desire, or educational requirements.
2. After all of this, there are still times when an error jumps out at me.
3. Usually at this time with a final read/edit...
...I am reminded; I have no Medical Qualifications and often breathe a sigh of relief.
1. Nice question and of course very valid.
2. Although only recently I created a written list of Checks and Balances - it is; a Standards and Priority protocol I have adopted in many ways for all of my Thirty-Four years as a therapist - although perhaps Guilty for not as I do today adhering to most if not all of them:
3. When I make such statements as this. "Never once has anyone demonstrated better knowledge or ability than myself." I apply these checks and Balances; to ensure I am not being - as you suggest; Psychotic and Delusional.
4. To count as equal or superior to Talking Cures - a therapeutic application or Institutional Body has to fit into this well tried and trusted - yet simple criteria.
Please read at this link:
Please read at this link:
Cystic Fibrosis Explored Explained Understood?
Courtesy of Wikipedia, the free Encyclopaedia:
This article is about making 2016 sense of this Individually Symptom Presented disorder...
Regarding Person's having disorders with many interrelated constantly changing symptoms - all with unknown cause and no known cure, requiring often over many years; constant Blood Tests whilst often taking many Medications.
Cystic Fibrosis Explored Explained Understood?
These explanations are from a collection of Scientifically Proven papers in the public domain and discussion forums and are in a Question and Answer forum style.
It is important to accept I am both the Questioner, on behalf of interested Person's as well as the Person supplying the Answers, or Responding thus in many ways - my own best critic.
Leaving one to choose the Questions and Answers that are important for a better or individual understanding of this seemingly mysterious illness.
Furthermore it is imperative one recognises; I have no medical qualifications to make such assertions as contained within the answers.
This should leave one in no doubt - it is only written because the entire medical profession sense its creation, have never once produced a cure for any illness.
A life-time of medication is not to be considered a cure - only management of an ever changing and most times growing list of symptoms and medications.
From Wikipedia, the free encyclopaedia Cystic fibrosis - Clubbing.
Clubbing in the fingers of a Person with Cystic Fibroses.
Classification and external resources
The most common congenital disease where a Child's lungs, intestines and pancreas become clogged with thick mucus..;
...caused by defect in a single gene; no cure is known.
Synonyms = Known by other names.
Specialty - Medical Genetics.
277.0 OMIM 219700
A. Cystic fibrosis MeSH D003550 Gene Reviews CFTR-Related Disorders
B. Cystic Fibrosis (CF) is a genetic disorder that affects mostly the lungs but also the pancreas, liver, kidneys and intestine.
C. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections.
D. Other signs and symptoms include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes and infertility in males, among others.
E. Different People may have different degrees of symptoms.
F. Cystic Fibrosis is inherited in an autosomal recessive manner.
G. It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein.
H. Those with a single working copy are carriers and otherwise mostly normal.
I. CFTR is involved in production of sweat, digestive fluids and mucus.
J. When CFTR is not functional; secretions, which are usually thin instead become thick.
K. The condition is diagnosed by a sweat test and genetic testing.
L. Screening of infants at birth takes place in some areas of the world.
M. The average life expectancy is between 42 and 50 years in the developed world.
N. Lung problems are responsible for death in 80% of people with Cystic Fibrosis.
O. Cystic Fibroses is most common among People of Northern European ancestry and affects about one out of every 3,000 new born Children.
P. About, one in 25 People are carriers.
Q. It is least common in Africans and Asians.
R. Dorothy Andersen first recognized Cystic Fibrosis as a specific disease in 1938, with descriptions that fit the condition occurring at least as far back as 1595.
S. The name Cystic Fibrosis refers to the characteristic fibrosis and cysts that form within the pancreas.
T. There is no known cure for Cystic Fibrosis.
1. Interesting to note - if one links Items B, E, F, G and concludes with M.
2. It is clear as item E demonstrates - this is not a Genetic disorder at all.
3. Item F. Can be nothing more than guesswork, looking for what one was expecting to Find or just explaining. "What" and never. "Why."
4. In addition, if one considers G as suggested to be a definitive CAUSE - should we not ask what caused that.
5. Moreover would it be wise to say in the absence of a cure - the closest the Medical Profession is able to determine short of accepting - illness is no more than the process of evolutionary change; to which Humans will never be able to see the outcome.
6. Because - The cause is not known and more research is required.
A. Lung infections are treated with antibiotics, which may be given intravenously, inhaled, or by mouth.
B. Sometimes, the antibiotic azithromycin is used long-term.
C. Inhaled hypertonic saline and salbutamol may also be useful.
D. Lung transplantation may be an option if lung function continues to worsen.
E. Pancreatic enzyme replacement and fat-soluble vitamin supplementation are important, especially in the young.
F. While not well supported by Scientifically Proven Evidenced based Medicine many People use airway clearance techniques such as chest physiotherapy.
1. The order of merit in this document is driven by the information available and apart from initiating history is in the same order received.
2. It surely must be said - treating new born Children with this disorder deserves the accolade our dedicated frontline clinicians can be given.
3. However should that blind us to the information contained just in this section relating to treatment - that most eloquently describes just how little is known about the disorder - yet still is listed as Scientifically Proven.
4. Is it not fair to say - so far this demonstrates no more than guesswork.
5. Moreover would treatment be better if the cause were truly known and the attending Doctors were able to discuss this with the Parents.
Question 1. How may I ask would discussing a Childs illness with the Parents be of any value - surely it is only through clinical decisions advances will be made?
A. One would like to think so, but - with 100,000 illnesses under the belt of medical science still awaiting a true cause found, leading to a successful cure...
1. Instead of, as this section alone demonstrates - poor management leading to more symptoms and eventual death from a long-term misunderstood disorder; Is medical knowledge ever going to improve.
B. Thus it is time to bring to bear the big guns, meaning - the true cause of this laughable so-called Genetic Disorder who will have the sole responsibility for the Childs life and as a result of medical ignorance will have no option but to perpetuate the disorder instead of making it at least livable in not curable, for all - including the Child.
Question. 2. What have you said there - now come on we cannot have that, without some form of justification; are you suggesting you already know the cause?
A. Now you know I do not make statements as this if I am not prepared to take from highly qualified professional - as I have no medical qualifications; threatening even demeaning chastisement for my unqualified un-provable suggestions.
B. When one considers and accepts and it is scientifically proven there are 7 billion people in the world and every one of them is 100% unique even identical twins - then one is able to consider proving anything that relates to illness in the Mind or Body is a Dream no one will ever be able to poses.
C. Knowing this - what would be the value if someone did poses such virtues, if no unique for each Person treatment were available - or at least universal understanding had been accepted by us all.
D. Since 1984 I have infiltrated myself into the United Kingdom's medical profession and since the advent of the Internet many medical institutions of the world - with the sole purpose of getting them to see they have never been right in their assertions ALL illness is Biological.
E. During all that time and still today, I remain convinced in modern times or perhaps in history of illness - no one has worked solely in the confines of the Mind to repair the Body, using only the immune systems and Body replication process.
F. It appears as a result of my work - some years ago, Scientific Medicine started to go into the Brain and more recently is attempting to go into the Mind - time will tell.
G. However No drugs will-ever-cure anything in the Mind and its ever-changing thought processes.
H.Thus when a Doctor or Therapist works to this protocol then at least one is speaking a modicum of truth relating to all illness being only a memory and in real terms nothing to do with the Body at all. I. Perhaps then and only then will someone offer a challenge I will relish as an equal. J. Until such times and any Doctor is able speak eloquently of the thousands of Patient's that have shared the belief - it was the Doctor that helped rather than the drugs and the Mind was recognised as playing a part in the healing - I remain unchallenged.
Question. 3.Excuse me but it appears you have not answered my question yet?
Answer. 3. No purposely - I feel sure there is many a mile to travel before we bring that into the equation.
Question. 4. You talk only about the Mind yet I am still unclear when you refer to the 'Mind.' As to just what this is and where it is? Please explain?
Answer. 4. It has lately been reported the process the Mind serves as the 'divining rod' to identify the frequency at which the Pain/illness and sound frequency resonate.
Question. 5. If I am reading you correctly are you referring to the concept of self-image Self-worth within this mix?
Answer. 5. Indeed I am for the entire contents within the Mind form what is the Emotional Phenotype - the image we show to the world that everyone see's and we experience as self.
A. The Mind in plain language is no more than a store of information acting as an exchange mechanism to alter the input from the binary code of the outside world into the internal world binary code, which instructs the Body at all times day and night - what to do.
Question. 6. So is the Mind to be considered our spiritual aspect and nothing to do with the Brain circuitry - that perpetuates Chronic Pain and illness?
Answer. 6. Sadly this is still very aged Medical Science thinking and very much back to front - for the Brain is no more than an Organ of the Body and achieves nothing whatsoever; without instructions from the Mind.
Question. 7. How then can I be assured of this?
Answer. 7. If there is anything I can assure you of it is - so far no one has ever understood the Mind and been able to utilise its power to self-repair Pain and illness using only the body's immune and replication processes that has for decades defied the very best scientific and complementary medicine.
A. Even with my knowledge - I am too many times amazed when as a team I work diligently with a Patient that came to me as a failure of many different therapeutic applications, only to find at the very last hurdle they will dismiss me out of hand. Even if per chance of luck, they are not paying for the treatment.
B. Therefore, one has to apply extreme caution as to just what is meant by the term - "Our Spiritual Aspect."
Question. 8. May we ask - what is and where is the Mind in a Body?
A. May we first look at the Spiritual Concept. This surely is no more than some form of religious thinking - an aspect of the Mind and its memories and nothing to do with the Body at all. Explained at this link Spirit and the sensation of Touch.
B. If as the evidence appears to suggest - I am the very first Person-therapy in history to only use the Mind to create repair of Mind-Brain-Body and Emotional concerns - and if I were to be pushed to answer the question "where is the Mind" I would have to say I do not know and more importantly have no desire too.
C. The reason for this is for too long the innocent People of this world have been victims of psychotic activity that interferes with the natural manner of the way we do things - religious Wars are a good example.
D. Therefor in all of my Thirty-Four years' experience only recently having been asked the question - have I ever thought to answer it.
E. Thus the best and perhaps only answer is. The Mind is in every single cell of the Body and the Body is no more than a lump of meat without it.
F. Any attempt to prove or disprove this will only result in tears for all concerned and even more failure of treatments that should be designed and applied for the Patient only and not ever to relieve the Anxiety of the therapist or sustain a lifestyle with more than adequate profits.
Signs and Symptoms.
1. The main signs and symptoms of Cystic Fibrosis are salty-tasting skin, poor growth and poor weight gain despite normal food intake, accumulation of thick, sticky mucus, frequent chest infections and coughing or shortness of breath.
2. Males can be infertile due to congenital absence of the Vas Deferens.
A. The Vas Deferens (Latin: "carrying-away vessel;" also called Ductus Deferens is part of the male reproductive system of many vertebrates; these vasa transport sperm from the epididymis to the ejaculatory ducts in anticipation of ejaculation.
3. Symptoms often appear in Infancy and Childhood, such as bowel obstruction due to meconium ileus in Newborn Babies.
A. Meconium Ileus (MI) is a condition where the content of the Baby's bowel (meconium) is extremely sticky and causes the bowel to be blocked at birth.
4. In most cases, the bowel itself is complete and intact - but it is just the inside that is blocked.
5. As the Children grow, they exercise to release mucus in the alveoli.
6. Ciliated epithelial cells in the Person have a mutated protein that leads to abnormally viscous mucus production.
7. The poor growth in Children typically presents as an inability to gain weight or height at the same rate as their peers and is occasionally not diagnosed until investigation is initiated for poor growth.
8. The causes of growth failure are multifactorial and include chronic lung infection, poor absorption of nutrients through the gastrointestinal tract and increased metabolic demand due to chronic illness.
9. In rare cases, Cystic Fibrosis can manifest itself as a coagulation disorder.
10. Vitamin K is normally absorbed from breast milk, formula and later, solid foods.
11. This absorption is impaired in some Cystic Fibrosis Patients.
12. Young Children are especially sensitive to vitamin K mal absorptive disorders because only a very small amount of vitamin K crosses the placenta, leaving the Child with very low reserves and limited ability to absorb vitamin K from dietary sources after birth.
13. Because factors II, VII, IX, and X - clotting factors, are vitamin K-dependent, low levels of vitamin K can result in coagulation problems.
14. Consequently, when a Child presents with unexplained bruising, a coagulation evaluation may be warranted to determine whether there is an underlying disease.
15. Lungs and sinuses Respiratory infections in CF varies according to age.
16. Green = Pseudomonas aeruginosa.
17. Brown = Staphylococcus aureus.
18. Blue = Haemophilus influenzae.
19. Red = Burkholderia cepacia complex Lung disease results from clogging of the airways due to mucus build-up, decreased mucociliary clearance and resulting inflammation.
20. Inflammation and infection cause injury and structural changes to the lungs, leading to a variety of symptoms.
21. In the early stages, incessant coughing, copious phlegm production and decreased ability to exercise are common.
22. Many of these symptoms occur when bacteria that normally inhabit the thick mucus grow out of control and cause pneumonia.
23. In later stages, changes in the architecture of the lung, such as pathology in the major airways - bronchiectasis, further exacerbate difficulties in breathing.
24. Other signs include coughing up Blood - hemoptysis, high Blood pressure in the lung - pulmonary hypertension, heart failure, difficulties getting enough Oxygen to the Body - hypoxia and respiratory failure requiring support with breathing masks, such as bilevel positive airway pressure machines or ventilators.
25. Staphylococcus aureus, Haemophilus influenzae and Pseudomonas aeruginosa are the three most common organisms causing lung infections in Cystic Fibrosis Patients.
26. In addition to typical bacterial infections, People with Cystic Fibrosis more commonly develop other types of lung disease.
27. Among these is allergic bronchopulmonary aspergillosis, in which the Body's response to the common fungus Aspergillus fumigatus causes worsening of breathing problems.
28. Another is infection with Mycobacterium avium complex (MAC), a group of bacteria related to tuberculosis, which can cause a lot of lung damage and does not respond to common antibiotics.
29. Mucus in the paranasal sinuses is equally thick and may also cause blockage of the sinus passages, leading to infection.
30. This may cause facial pain, fever, nasal drainage and headaches.
31. Individuals with Cystic Fibrosis may develop overgrowth of the nasal tissue - nasal polyps due to inflammation from chronic sinus infections.
32. Recurrent sinonasal polyps can occur in as many as 10% to 25% of Cystic Fibrosis Patients.
33. These polyps can block the nasal passages and increase breathing difficulties.
34. Cardiorespiratory complications are the most common cause of death (~80%) in Patients at most Cystic Fibrosis facilities in the United States.
35. Gastrointestinal Prior to prenatal and newborn screening, Cystic Fibrosis was often diagnosed when a new born infant failed to pass faeces - meconium.
36. Meconium may completely block the intestines and cause serious illness.
37. This condition, called meconium ileus, occurs in 5–10% of new born Children with Cystic Fibrosis.
38. In addition, protrusion of internal rectal membranes, rectal prolapse, is more common, occurring in as many as 10% of Children with Cystic Fibrosis and it is caused by increased faecal volume, malnutrition and increased intra–abdominal pressure due to coughing.
39. The thick mucus seen in the lungs has a counterpart in thickened secretions from the pancreas, an organ responsible for providing digestive juices that help break down food.
40. These secretions block the exocrine movement of the digestive enzymes into the duodenum and result in irreversible damage to the pancreas, often with painful inflammation - pancreatitis.
A. Exocrine glands...B. Exocrine glands are glands that produce and secrete substances onto an epithelial surface by way of a duct. C. Examples of exocrine glands include sweat, salivary, mammary, ceruminous, lacrimal, sebaceous and mucous.
41. The pancreatic ducts are totally plugged in more advanced cases of Cystic Fibrosis, usually seen in older Children or Adolescents.
42. This causes atrophy of the exocrine glands and progressive fibrosis.
43. The lack of digestive enzymes leads to difficulty absorbing nutrients with their subsequent excretion in the faeces, a disorder known as malabsorption.
44. Malabsorption leads to malnutrition and poor growth and development because of calorie loss.
45. Resultant hypoproteinemia may be severe enough to cause generalized edema.
46. Individuals with Cystic Fibrosis also have difficulties absorbing the fat-soluble vitamins A, D, E and K.
47. In addition to the pancreas problems, People with Cystic Fibrosis experience more heartburn, intestinal blockage by intussusception and constipation.
48. Older individuals with Cystic Fibrosis may develop distal intestinal obstruction syndrome when thickened faeces cause intestinal blockage.
49. Exocrine pancreatic insufficiency occurs in the majority (85% to 90%) of Patients with Cystic Fibrosis.
50. It is mainly associated with "severe" CFTR mutations, where both alleles are completely non-functional.
51. It occurs in 10% to 15% of Patients with one "severe" and one "mild" CFTR mutation where there still is a little CFTR activity, or where there are two "mild" CFTR mutations.
52. In these milder cases, there is still sufficient pancreatic exocrine function so that enzyme supplementation is not required.
53. There are usually no other GI complications in pancreas-sufficient phenotypes and in general, such individuals usually have excellent growth and development.
54. Despite this, idiopathic chronic pancreatitis can occur in a subset of pancreas-sufficient individuals with Cystic Fibrosis and is associated with recurrent abdominal pain and life-threatening complications.
A. Idiopathic - relating to or denoting any disease or condition which arises spontaneously or for which the cause is unknown.
55. Thickened secretions also may cause liver problems in Patients with Cystic Fibrosis.
56. Bile secreted by the liver to aid in digestion may block the bile ducts, leading to liver damage.
57. Over time, this can lead to scarring and nodularity - cirrhosis.
58. The liver fails to rid the Blood of toxins and does not make important proteins, such as those responsible for Blood clotting.
59. Liver disease is the third most common cause of death associated with Cystic Fibrosis.
A. If one takes - Salty Skin is one of the first signs a Child is able to be Diagnosed with Cystic Fibrosis and we accept management of symptoms is the best our dedicated Doctors are able to offer at this time due to the lack of or availability of secure evidenced based medicine - as to the cause.
B. Should not more effort be placed into finding the true cause, which clearly cannot be anything the Child caught and time could not have caused or contributed to the inflammation type symptoms.
C. No more than Genetics - thus there has to be another answer perhaps hidden in clear sight of those who do not desire to see it.
D. Item 10 refers to "Vitamin K is normally absorbed." Surely there is something wrong with the science if only one of the Two>Four thousand body chemicals is considered.
E. Items 22 and 28 make reference to Bacteria as Causing a lot of Lung damage - is this correct or just guesswork based on the inability to know the cause of Cystic Fibrosis and the understanding required to see the possibility - Bacteria is no more than an expression of the Body Chemistry.
B. The pancreas contains the islets of Langerhans, which are responsible for making insulin, a hormone that helps regulate Blood glucose.
C. Damage of the pancreas can lead to loss of the islet cells, leading to a type of diabetes that is unique to those with the disease.
D. This Cystic Fibrosis-related diabetes (CFRD) shares characteristics that can be found in type 1 and type 2 diabetics and is one of the principal nonpulmonary complications of Cystic Fibrosis.
E. Vitamin D is involved in calcium and phosphate regulation.
F. Poor uptake of vitamin D from the diet because of malabsorption can lead to the bone disease osteoporosis in which weakened bones are more susceptible to fractures.
G. In addition, People with Cystic Fibrosis often develop clubbing of their fingers and toes due to the effects of chronic illness and low Oxygen in their tissues.
H. Infertility affects both Men and Women.
I. At least 97% of Men with Cystic Fibrosis are infertile, but not sterile and can have Children with assisted reproductive techniques.
J. The main cause of infertility in Men with Cystic Fibrosis is congenital absence of the vas deferens - which normally connects the testes to the ejaculatory ducts of the penis, but potentially also by other mechanisms such as causing no sperm, teratospermia and few sperm with poor motility.
K. Many men found to have congenital absence of the vas deferens during evaluation for infertility have a mild, previously undiagnosed form of Cystic Fibrosis.
L. Approximately 20% of Women with Cystic Fibrosis have fertility difficulties due to thickened cervical mucus or malnutrition.
M. In severe cases, malnutrition disrupts ovulation and causes amenorrhea.
1. If one knew nothing at all about Cystic Fibrosis then this section is very informative - however when it comes to medical science it falls not only short of the mark in reality it is not even a starter.
2. When such times the Medical profession involve themselves in item I, "assisted reproductive techniques." Yet do not know the cause of Cystic Fibrosis is this for their own Anxiety relief - Profit only and nothing to do with the Person and although recognising a Persons fundamental right to procreate, is in the long-term; adding more injury to the Person, the Child and Humanity.
3. However with Sepsis once again grabbing the attention of the mass media (December 2016) who are demanding after all these years the cause and a cure is found.
4. Little hope, must there be for People with Endocrine and Cystic Fibrosis medical mysteries.
1. Cystic Fibrosis has an autosomal recessive pattern of inheritance caused by a mutation in the gene Cystic Fibrosis transmembrane conductance regulator - CFTR.
2. The most common mutation, ΔF508, is a deletion - Δ signifying deletion of three nucleotides that results in a loss of the Amino Acid phenylalanine (F) at the 508th position on the protein.
3. This mutation accounts for two-thirds (66–70%) of Cystic Fibrosis cases worldwide and 90% of cases in the United States; however, there are over 1500 other mutations that can produce Cystic Fibrosis.
4. Although most People have two working copies - alleles of the CFTR gene, only one is needed to prevent Cystic Fibrosis.
5. Cystic Fibrosis develops when neither allele can produce a functional CFTR protein.
6. Thus, CF is considered an autosomal recessive disease.
7. The CFTR gene, found at the q31.2 locus of chromosome 7, is 230,000 base pairs long and creates a protein that is 1,480 Amino Acids long.
8. More specifically the location is between base pair 117,120,016 to 117,308,718 on the long arm of chromosome 7, region 3, band 1 and sub-band 2, represented as 7q31.2.
9. Structurally, CFTR is a type of gene known as an ABC gene.
10. The product of this gene (the CFTR) is a chloride ion channel important in creating sweat, digestive juices and mucus.
11. This protein possesses two ATP-hydrolysing domains, which allows the protein to use energy in the form of ATP.
12. It also contains two domains comprising 6 alpha helices apiece, which allow the protein to cross the cell membrane.
13. A regulatory binding site on the protein allows activation by phosphorylation, mainly by cAMP-dependent protein kinase.
14. The carboxyl terminal of the protein is anchored to the cytoskeleton by a PDZ domain interaction.
15. In addition, there is increasing evidence that genetic modifiers besides CFTR modulate the frequency and severity of the disease.
16. One example is mannan-binding lectin, which is involved in innate immunity by facilitating phagocytosis of microorganisms.
17. Polymorphisms in one or both mannan-binding lectin alleles that result in lower circulating levels of the protein are associated with a threefold higher risk of end-stage lung disease, as well as an increased burden of chronic bacterial infections.
18. Pathophysiology The CFTR protein is a channel protein that controls the flow of H2O and Cl- ions in and out of cells inside the lungs.
19. When the CFTR protein is working correctly, ions freely flow in and out of the cells.
20. However, when the CFTR protein is malfunctioning, these ions cannot flow out of the cell due to a blocked channel.
21. This causes Cystic Fibrosis, characterized by the build -up of thick mucus in the lungs.
22. There are several mutations in the CFTR gene and different mutations cause different defects in the CFTR protein, sometimes causing a milder or more severe disease.
23. These protein defects are also targets for drugs, which can sometimes restore their function.
24. ΔF508-CFTR, which occurs in >90% of Patients in the U.S., creates a protein that does not fold normally and is not appropriately transported to the cell membrane, resulting in its degradation.
25. Other mutations result in proteins that are too short - truncated, because production is ended prematurely.
26. Other mutations produce proteins that: do not use energy normally, do not allow chloride, iodide and thiocyanate to cross the membrane appropriately, degrade at a faster rate than normal.
27. Mutations may also lead to fewer copies of the CFTR protein being produced.
28. The protein created by this gene is anchored to the outer membrane of cells in the sweat glands, lungs, pancreas and all other remaining exocrine glands in the Body.
29. The protein spans this membrane and acts as a channel connecting the inner part of the cell (cytoplasm) to the surrounding fluid.
30. This channel is primarily responsible for controlling the movement of halogens from inside to outside of the cell; however, in the sweat ducts it facilitates the movement of chloride from the sweat duct into the cytoplasm.
31. When the CFTR protein does not resorb ions in sweat ducts, chloride and thiocyanate released from sweat glands are trapped inside the ducts and pumped to the skin.
32. Conclusion. I feel sure the scientists that created this body of work on Genetics are able to repeat this verbatim. With items 2, 3, 4, 7 and 8 - confirming this is for the funding not anything to do with establishing the cause and an effective treatment. Thus is for Medical Science never the Patient.
Question. 1. In understanding - the true cause is not known and there is no known cure? Can you please explain what you mean when referring to Items 2, 3, 4, 7 and 8?
5. Answer. 1...
A. Yes of course... May we first view these extracts.
2. Loss of the Amino Acid phenylalanine (F) at the 508th position on the protein.
3. Over 1500 other mutations that can produce Cystic Fibrosis.
4. Only one is needed to prevent Cystic Fibrosis.
7. Is 230,000 base pairs long and creates a protein that is 1,480 Amino Acids long.
8. Base pair 117,120,016 to 117,308,718.
B. Surely it does not take much in the way of mathematical understandings to see the enormity of the numbers used here must surely demonstrate - there has to be a more simple answer than that attempting to find it in a calculator...
C. Leaving one as myself, always thinking Science seeks simple answers to complex questions.
D. For to change just one Body Chemical and all of the numbers resulting from any calculation no matter how profound - are rendered, of Novel but no real Scientific Value.
Question. 2. Is there more to items 12 and 20?
Answer. 2. Indeed there is, for if we take this extract, "(item 12) allow the protein to cross the cell membrane." and balance this (item 20) against, "protein is malfunctioning." There is surely an allowance for us to ask - is this really Genetic or a Biological fault or as on instructed by the Mind.
Salt or Sodium.
A. Additionally - hypothiocyanite, OSCN, cannot be produced by the immune defence system.
B. Because chloride is negatively charged, this modifies the electrical potential inside and outside the cell that normally causes cations to cross into the cell.
C. Sodium is the most common cation in the extracellular space.
1. Cation - a positively charged ion, i.e. one that would be attracted to the cathode in electrolysis.
D. The excess chloride within sweat ducts prevents sodium reabsorption by epithelial sodium channels and the combination of sodium and chloride creates the salt, which is lost in high amounts in the sweat of individuals with Cystic Fibrosis.
E. This lost salt forms the basis for the sweat test.
F. Most of the damage in Cystic Fibrosis is due to blockage of the narrow passages of affected organs with thickened secretions.
G. These blockages lead to remodelling and infection in the lung, damage by accumulated digestive enzymes in the pancreas, blockage of the intestines by thick faeces, etc.
H. There are several theories on how the defects in the protein and cellular function cause the clinical effects.
I. The most current theory suggests that defective ion transport leads to dehydration in the airway epithelia, thickening mucus.
J. In airway epithelial cells, the cilia exist in between the cell's apical surface and mucus in a layer known as Airway Surface Liquid (ASL).
K. The flow of ions from the cell and into this layer is determined by ion channels like CFTR.
L. CFTR not only allows Chloride ions to be drawn from the cell and into the ASL, but it also regulates another channel called ENac.
M. ENac allows sodium ions to leave the ASL and enter the respiratory epithelium.
N. CFTR normally inhibits this channel, but if the CFTR is defective, then sodium will flow freely from the ASL and into the cell.
O. As water follows sodium, the depth of ASL will be depleted and the cilia will be left in the mucous layer.
P. As cilia cannot effectively move in a thick viscous environment, there is deficient mucociliary clearance and a build-up of mucous, clogging small airways.
Q. The accumulation of more viscous, nutrient-rich mucus in the lungs allows bacteria to hide from the Body's immune system, causing repeated respiratory infections.
R. The presence of the same CFTR proteins in pancreatic duct and skin cells are what cause symptoms in these systems.
1. Item A - suggests; "cannot be produced by the immune defence system." If one was to add - this is not required as the Mind is trying to right a wrong not demonstrate there is something wrong.
2. Irrespective as to what it is referred to Salt or Sodium the first thing we must recognise is - no amount of trying with different applications; add or subtract Salt/Sodium safely from a Body.
3. It also imperative to recognise; "The excess chloride within sweat ducts prevents sodium reabsorption;" is no more than a symptom no amount of management will ease.
4. It is reported - There are several theories on how the defects in the protein and cellular function cause." Furthermore - it is also reported Oxford dictionary are contesting Medical Science use of the word "theories" as excessive and with no meaning.
5. Confirmed by there being no explanation for - "allows bacteria to hide from the Body's immune system."
6. All Scientifically proven with - Proteins in pancreatic duct and skin cells are what cause symptoms in these systems.
A. May we accept this and ask if this is so - "Proteins in pancreatic duct and skin cells are what CAUSES?" should we not ask - what caused these; as clearly they are no more than symptoms.
A. The lungs of individuals with Cystic Fibrosis are colonized and infected by bacteria from an early age.
B. These bacteria, which often spread among individuals with Cystic Fibrosis, thrive in the altered mucus, which collects in the small airways of the lungs.
C. This mucus leads to the formation of bacterial microenvironments known as biofilms that are difficult for immune cells and antibiotics to penetrate.
D. Viscous secretions and persistent respiratory infections repeatedly damage the lung by gradually remodelling the airways, which makes infection even more difficult to eradicate.
E. Over time, both the types of bacteria and their individual characteristics change in individuals with Cystic Fibrosis.
F. In the initial stage, common bacteria such as Staphylococcus aureus and Haemophilus influenzae colonize and infect the lungs.
G. Eventually, Pseudomonas aeruginosa and sometimes Burkholderia cepacia dominate.
H. By 18 years of age, 80% of Patients with classic Cystic Fibrosis - harbour P. aeruginosa and 3.5% harbour B. cepacia.
I. Once within the lungs, these bacteria adapt to the environment and develop resistance to commonly used antibiotics.
J. Pseudomonas can develop special characteristics that allow the formation of large colonies, known as "mucoid" Pseudomonas, which are rarely seen in People that do not have Cystic Fibrosis.
K. One way infection spreads is by passing between different individuals with Cystic Fibrosis.
L. In the past, People with Cystic Fibrosis often participated in summer - Camps and other recreational gatherings.
M. Hospitals grouped Patients with Cystic Fibrosis into common areas and routine equipment - such as nebulizers was not sterilized between individual Patients.
O. This led to transmission of more dangerous strains of bacteria among groups of Patients.
P. As a result, individuals with Cystic Fibrosis are now routinely isolated from one another in the healthcare setting and healthcare providers are encouraged to wear gowns and gloves when examining Patients with Cystic Fibrosis to limit the spread of virulent bacterial strains.
Q. Cystic Fibrosis Patients may also have their airways chronically colonized by filamentous fungi - such as Aspergillus fumigatus, Scedosporium apiospermum, Aspergillus terreus and/or yeasts - such as Candida Albicans; other filamentous fungi less commonly isolated include Aspergillus flavus and Aspergillus nidulans - occur transiently in Cystic Fibrosis respiratory secretions and Exophiala dermatitidis and Scedosporium prolificans - chronic airway-colonizers; some filamentous fungi like Penicillium emersonii and Acrophialophora fusispora are encountered in Patients almost exclusively in the context of Cystic Fibrosis.
U. Defective mucociliary clearance characterizing Cystic Fibrosis is associated with local immunological disorders.
V. In addition, the prolonged therapy with antibiotics and the use of corticosteroid treatments may also facilitate fungal growth.
X. Although the clinical relevance of the fungal airway colonization is still a matter of debate, filamentous fungi may contribute to the local inflammatory response and therefore to the progressive deterioration of the lung function, as often happens with allergic broncho -pulmonary aspergillosis (ABPA) – the most common fungal disease in the context of Cystic Fibrosis, involving a Th2-driven immune response to Aspergillus.
1. It took me a while to see through the facade of this section - the clues eventually jumped out at me in items B, D, G, I, K, V and X.
2. For they all tell The "What" about the disease and none say "Why." Giving rise to the belief - no attempt is offered in order to find out.
3. Item V really states all and X confirms - the Medical profession instead of working to make the sufferer well, are in fact making the situation much worse.
A. Is this really, because they do not know or just about funding for more research and profit as being a failed clinician is not in their code of conduct.
Diagnosis and Monitoring.
1. The location of the CFTR gene on chromosome 7 Cystic Fibrosis may be diagnosed by many different methods including new born screening, sweat testing and genetic testing.
2. As of 2006 in the United States, 10 per cent of cases are diagnosed shortly after birth as part of new born screening programs.
3. The new born screen initially measures for raised Blood concentration of immunoreactive trypsinogen.
4. Infants with an abnormal new born screen need a sweat test to confirm the Cystic Fibrosis diagnosis.
5. In many cases, a Parent makes the diagnosis because the infant tastes salty.
6. Trypsinogen levels can be increased in individuals who have a single mutated copy of the CFTR gene - carriers or, in rare instances, in individuals with two normal copies of the CFTR gene.
7. Due to these false positives, Cystic Fibrosis screening in a new born can be controversial.
8. Most states and countries do not screen for Cystic Fibrosis routinely at birth.
9. Therefore, most individuals are diagnosed after symptoms e.g. sinopulmonary disease and GI manifestations prompt an evaluation for Cystic Fibrosis.
10. The most commonly used form of testing is the sweat test.
11. Sweat-testing involves application of a medication that stimulates sweating (pilocarpine).
12. To deliver the medication through the skin, iontophoresis is used to, whereby one electrode is placed onto the applied medication and an electric current is passed to a separate electrode on the skin.
13. The resultant sweat is then collected on filter paper or in a capillary tube and analysed for abnormal amounts of sodium and chloride.
14. People with Cystic Fibrosis have increased amounts of sodium and chloride in their sweat.
15. In contrast, People with Cystic Fibrosis have less thiocyanate and hypothiocyanite in their saliva and mucus.
16. Cystic Fibrosis can also be diagnosed by identification of mutations in the CFTR gene.
17. People with Cystic Fibrosis may be listed in a disease registry that allows researchers and doctors to track health results and identify candidates for clinical trials.
18. Prenatal Couples who are pregnant or planning a pregnancy can have themselves tested for the CFTR gene mutations to determine the risk that their Child will be born with Cystic Fibrosis.
19. Testing is typically performed first on one or both Parents and, if the risk of Cystic Fibrosis is high, testing on the Foetus is performed.
20. The American College of Obstetricians and Gynaecologists (ACOG) recommends testing for couples who have a personal or close family history of Cystic Fibrosis and they recommend that carrier testing be offered to all Caucasian couples and be made available to couples of other ethnic backgrounds.
21. Because development of Cystic Fibrosisin the Foetus requires each Parent to pass on a mutated copy of the CFTR gene and because Cystic Fibrosis testing is expensive, testing is often performed initially on one Parent.
22. If testing shows that Parent is a CFTR gene mutation carrier, the other Parent is tested to calculate the risk that their Children will have Cystic Fibrosis.
23. Cystic Fibrosis can result from more than a thousand different mutations and as of 2006, it is not possible to test for each one.
24. Testing analyses the Blood for the most common mutations such as ΔF508-most commercially available tests look for 32 or fewer different mutations.
25. If a family has a known uncommon mutation, specific screening for that mutation can be performed.
26. Because not all known mutations are found on current tests, a negative screen does not guarantee that a Child will not have Cystic Fibrosis.
27. During pregnancy, testing can be performed on the placenta - chorionic villus sampling or the fluid around the Foetus - amniocentesis.
28. However, chorionic villus sampling has a risk of fetal death of 1 in 100 and amniocentesis of 1 in 200; a recent study has indicated this may be much lower, approximately 1 in 1,600.
29. Economically, for carrier couples of Cystic Fibrosis, when comparing preimplantation genetic diagnosis (PGD) with natural conception (NC) followed by prenatal testing and abortion of affected pregnancies, PGD provides net economic benefits up to a maternal age of approximately 40 years, after which NC, prenatal testing and abortion has higher economic benefit.
A. It surely cannot and must not - be under or overestimated the dedication our Doctors impart, despite the continual failure to even manage many symptoms well - as items: 7, 11, 14, confirm with, "False Positives."
B. As especially 17 with; "listed in a disease registry that allows researchers and Doctors to track health results and identify candidates for clinical trials."
C. With items 23 "a thousand different mutations" and 26; clearly demonstrating - much of the testing is for the clinician/researcher and fund provider - never for the sufferer.
D. Through to 29. Provided net economic benefits."
E. Could the answer to this multifaceted ever changing symptom led illness be more simple to comprehend - if not accept, as there is no profit in secure quality knowledge.
F. It becomes extremely clear no advances have been made as - profit is the motivation and the study of genetics a waste of time; providing only information the researchers knew was there and just had to demonstrate to the fund providers they were looking.
A. While there are no cures for Cystic Fibrosis, there are several treatment methods.
B. The management of Cystic Fibrosis has improved significantly over the past 70 years.
C. While infants born with Cystic Fibrosis 70 years ago would have been unlikely to live beyond their first year, infants today are likely to live well into adulthood.
D. Recent advances in the treatment of Cystic Fibrosis have meant that an individual with Cystic Fibrosis can live a fuller life less encumbered by their condition.
E. The cornerstones of management are proactive treatment of airway infection, and encouragement of good nutrition and an active lifestyle.
F. Pulmonary rehabilitation as a management of Cystic Fibrosis continues throughout a Person's life and is aimed at maximizing organ function and therefore quality of life.
G. At best, current treatments delay the decline in organ function.
H. Because of the wide variation in disease symptoms, treatment typically occurs at specialist multidisciplinary centres and is tailored to the individual.
I. Targets for therapy are the lungs, gastrointestinal tract - including pancreatic enzyme supplements, the reproductive organs - including assisted reproductive technology (ART) and psychological support.
J. The most consistent aspect of therapy in Cystic Fibrosis is limiting and treating the lung damage caused by thick mucus and infection, with the goal of maintaining quality of life.
K. Intravenous inhaled and oral antibiotics, are used to treat chronic and acute infections.
L. Mechanical devices and inhalation medications are used to alter and clear the thickened mucus.
M. These therapies, while effective, can be extremely time-consuming.
1. Medical Science would have us believe over the past 70 years great advances have been made.
2. If we simply accept item B, C and D - does this not allow us to look in different directions to find satisfactory answers instead of guesswork and then look more seriously at other more important items as G and I.
3. Long-since has Scientific Medicine self-proclaimed; it was they who introduced the premise of cleanliness are next to goodliness and nothing to do with Mankind.
4. Surely since Adam and Eve mankind has sought to improve and thereby make things better - it may well have been the stench of rotting food and Human and Animal waste in the gutters that created the changes and very little to do with the invention of Antibiotics.
5. Surely, G confirms with this disease as with many others at the moment until the cause and a cure are found for any illness - Medical Science is only Long-term Medically Assisted Death.
6. Item I very cleverly makes Psychological almost an addition or is it better said of Novel but no Scientific Value.
7. Can or should we really believe this - "While there are no cures for Cystic Fibrosis, at best, current treatments delay the decline in organ function," should we ask; what is the true impact of this statement so often used; on all of the frontline clinicians and the decisions made and more importantly the treatments they offer.
1. Many People with Cystic Fibrosis are on one or more antibiotics at all times, even when healthy, to prophylactically suppress infection.
A. Prophylactic is a medication or a treatment designed and used to prevent a disease from occurring.
B. For example, prophylactic antibiotics may be used after a bout of rheumatic fever to prevent the subsequent development of Sydenham's Chorea.
2. Antibiotics are absolutely necessary whenever pneumonia is suspected or there has been a noticeable decline in lung function and are usually chosen based on the results of a sputum analysis and the Person's past response.
3. This prolonged therapy often necessitates hospitalization and insertion of a more permanent IV such as a peripherally inserted central catheter (PICC line) or Port-a-Cath.
4. Inhaled therapy with antibiotics such as tobramycin, colistin and aztreonam is often given for months at a time to improve lung function by impeding the growth of colonized bacteria.
5. Inhaled antibiotic therapy helps lung function by fighting infection, but also has significant drawbacks like development of antibiotic resistance, tinnitus and changes in the voice
6. Oral antibiotics such as ciprofloxacin or azithromycinare given to help prevent infection or to control on going infection.
7. The aminoglycoside antibiotics e.g. tobramycin used can cause hearing loss, damage to the balance system in the inner ear or kidney problems with long-term use.
8. To prevent these side effects, the amount of antibiotics in the Blood is routinely measured and adjusted accordingly.
9. Other treatments for lung disease Several mechanical techniques are used to dislodge sputum and encourage its expectoration.
10. In the hospital setting, chest physiotherapy (CPT) is utilised; a respiratory therapist percusses an individual's chest with his or her hands several times a day, to loosen up secretions.
11. Devices that recreate this percussive therapy include the ThAIRapy Vest and the intrapulmonary percussive ventilator (IPV).
12. Newer methods such as Biphasic Cuirass Ventilation and associated clearance mode available in such devices, integrate a cough assistance phase, as well as a vibration phase for dislodging secretions.
13. Biphasic Cuirass Ventilation, or Hayek BCV as it is better known, is a simple concept. Breathing Machine, which consists of two phases: Inspiration and Expiration. These are portable and adapted for home use.
14. Ivacaftor is an oral medication for the treatment of Cystic Fibrosis due to a number of specific mutations.
15. It improves lung function by about 10%; however, as of 2014 is expensive.
16. Aerosolized medications that help loosen secretions include dornase alfa and hypertonic saline.
17. Dornase is a recombinant human deoxyribonuclease, which breaks down DNA in the sputum, thus decreasing its viscosity.
18. Denufosol is an investigational drug that opens an alternative chloride channel, helping to liquefy mucus.
19. It is unclear if inhaled corticosteroids are useful.
20. As lung disease worsens, mechanical breathing support may become necessary. Individuals with Cystic Fibrosis may need to wear special masks at night that help push air into their lungs.
21. These machines, known as bilevel positive airway pressure (BiPAP) ventilators, help prevent low Blood Oxygen levels during sleep.
22. BiPAP may also be used during physical therapy to improve sputum clearance.
23. During severe illness, a tube may be placed in the throat - a procedure known as a tracheostomy to enable breathing supported by a ventilator.
24. For Children, preliminary studies show massage therapy may help People and their family's quality of life.
25. It is unclear what effect pneumococcal vaccination has as it has not been studied as of 2014.
26. Transplantation Lung transplantation often becomes necessary for individuals with Cystic Fibrosis as lung function and exercise tolerance decline.
27. Although single lung transplantation is possible in other diseases, individuals with Cystic Fibrosis must have both lungs replaced because the remaining lung might contain bacteria that could infect the transplanted lung.
28. A pancreatic or liver transplant may be performed at the same time in order to alleviate liver disease and/or diabetes.
29. Lung transplantation is considered when lung function declines to the point where assistance from mechanical devices is required or someone's survival is threatened.
30. Other aspects Intracytoplasmic sperm injection can be used to provide fertility for Men with Cystic Fibrosis.
31. New born Children with intestinal obstruction typically require surgery, whereas adults with distal intestinal obstruction syndrome typically do not.
32.Treatment of pancreatic insufficiency by replacement of missing digestive enzymes allows the duodenum to properly absorb nutrients and vitamins that would otherwise be lost in the faeces.
33. However, the best dosage and form of pancreatic enzyme replacement is unclear, as are the risks and long-term effectiveness of this treatment.
34. So far, no large-scale research involving the incidence of atherosclerosis and coronary heart disease in adults with Cystic Fibrosis has been conducted.
35. This is likely due to the fact that the vast majority of People with Cystic Fibrosis do not live long enough to develop clinically significant atherosclerosis or coronary heart disease.
36. Diabetes is the most common non-pulmonary complication of Cystic Fibrosis.
37. It mixes features of type 1 and type 2 Diabetes and is recognized as a distinct entity, Cystic Fibrosis-related diabetes (CFRD).
38. While oral anti-diabetic drugs are sometimes used, the only recommended treatment is the use of insulin injections or an insulin pump and, unlike in type 1 and 2 Diabetes, dietary restrictions are not recommended.
39. Development of osteoporosis can be prevented by increased intake of vitamin D and calcium and can be treated by bisphosphonates, although adverse effects can be an issue.
40. Poor growth may be avoided by insertion of a feeding tube for increasing calories through supplemental feeds or by administration of injected growth hormone.
41. Sinus infections are treated by prolonged courses of antibiotics.
42. The development of nasal polyps or other chronic changes within the nasal passages may severely limit airflow through the nose and over time reduce the Person's sense of smell.
43. Sinus surgery is often used to alleviate nasal obstruction and to limit further infections.
44. Nasal steroids such as fluticasone are used to decrease Nasal inflammation.
45. Female infertility may be overcome by assisted reproduction technology, particularly embryo transfer techniques.
46. Male infertility caused by absence of the vas deferens may be overcome with testicular sperm extraction (TESE), collecting sperm cells directly from the testicles.
47. If the collected sample contains too few sperm cells to likely have a spontaneous fertilization, intracytoplasmic sperm injection can be performed.
A. Intracytoplasmic sperm injection (ICSI, pronounced /ɪksiː/, IK-see) is an in vitro fertilization procedure in which a single sperm is injected directly into an egg.
48. Third party reproduction is also a possibility for Women with Cystic Fibrosis.
49. It is unclear if taking antioxidants affects outcomes.
50. Conclusion... During the recent past years many controversies have emerged and been discussed regarding the overuse of Antibiotic is destroying the drug's efficacy.
Re. Item 49...
A. Antioxidants are manufactured or natural substances that may prevent or delay some types of cell damage.
B. Antioxidants are found in many foods, including fruits and vegetables.
C. They are also available as dietary supplements.
D. Examples of antioxidants include - Beta-carotene.
E. Sadly this is no more than what would expected of Medical Science if one is making the smoke as just this section 11 demonstrates best call the kettle black.
F. Explained in plain language as - Black or Block the way for any other Health Care Practitioner from working with a Person with a Mysterious to the Medical Profession illness in order that they are able to continue to profit nicely from continual failure.
G. I have extracted from the above list and compressed it down to just the red highlighted items - in order to make a response to these only.
Item 1. Even when healthy, too prophylactically.
Answer. Item 1. Is this not sufficient to demonstrate nothing is working.
Item. 1. B. To prevent Sydenham's Chorea.
Answer. 1. B. Clearly demonstrating this is created as a result of the treatment not achieving what it was supposedly designed for.
Item 3. This prolonged therapy often necessitates hospitalization.
Answer. Item 3. Although it must again be recognised our dedicated Doctors are doing their very best - Is it not time to stand back and compare the Science against the outcome.
Item 5. In so doing also recognise the significant drawbacks in the development of antibiotic resistance, tinnitus and changes in the voice.
Answer. Item 5. Does one really have to stand back or is the answer all hidden in plain sight.
Item 7. The aminoglycoside antibiotics e.g. tobramycin used can cause hearing loss, damage to the balance system in the inner ear or kidney problems with long-term use.
Answer. Item 7. Confirmation of Answer item 5.
Item 8. To prevent these side effects, Blood is routinely measured and adjusted accordingly.
Answer. Item 8. Need one say more.
Item 12. Biphasic Cuirass Ventilation
Answer. Item 12. Although one surely must consider this only a stepping stone to death - we should not overlook medical staffs dedicated efforts to manage the ever-changing symptoms of those unable to speak and argue for themselves; should this blind one from the reality - Management is not working and what then is the cause and can it be prevented.
Item 14. Due to a number of specific mutations.
Answer. Item 14. Is there not sufficient information in this extract alone to demonstrate this illness is not of genetic creation. If it were surely no medication would affect the symptom presentation.
Item 15. However, as of 2014 is expensive.
Answer. Item 15. How much more expensive can it be to keep with highly qualified medical staff adding more and more medications creating more and more symptoms and still the Person dies.
Item 17. Breaks down DNA .
Answer. Item 17. Is this not a confirmation DNA is a use once process in the creation of Life and it is a working copy that medications are able to alter.
Item 19. It is unclear if inhaled corticosteroids are useful.
Answer. Item 19. Is this not medical science at its best - If the complex cannot be answered simply ignoring the evidence.
Item 20. As lung disease worsens.
Answer. Item 20. As clear a demonstration one could desire to see the Scientific Data - evidence base has been calculated incorrectly.
Item 21. Help prevent low blood oxygen levels during sleep.
Answer. Item 21. All very well and good to have a machine to do this - does it not demonstrate the blindness of Scientific Medication of days gone by - Prevention is better than cure.
Item 25. It is unclear what effect pneumococcal vaccination has - as it has not been studied as of 2014.
Answer. Item 25. Of course it has not been studied no profit in studying a medication designed to prevent one illness and in so doing creates other more serious side effects.
A. Although reported to be rare, include: high temperature, possibly leading to convulsions - febrile seizures and an allergic itchy skin rash.
Item 26. Lung transplantation often becomes necessary.
Answer. Item 26. Surely in the absence of good management and a cure - if this be the only option we must support it if there is some long-term relieve for any Person with the disorder.
A. Surely, if there is no long-term relief we must have the courage to ask. "Who was the transplant really for."
Item 30. Other aspects Intracytoplasmic sperm injection can be used to provide fertility for Men with Cystic Fibrosis.
Answer. Item 30. Whilst one must recognise Procreation is mankind's number one priority - thus a fundamental right, not a gift.
A. Should we not have the integrity and wisdom in order to ask. "If this illness is genetically caused just what does the medical profession think it is doing by assisting in Childbirth.
Item 33. However, the best dosage and form of pancreatic enzyme replacement is unclear, as are the risks and long-term effectiveness of this treatment.
Answer. Item 33. A self-demonstration if ever there was one.
Item 34. No large-scale research involving the incidence of atherosclerosis and coronary heart disease in adults with Cystic Fibrosis has been conducted.
Answer. Item 34. Item 35 beautifully answers this.
Item 35. Cystic Fibrosis do not live long enough.
Answer. Item 35. The scientific evidence is clear regarding lifespan - however it is 2017 now should we still be saying this or looking further back to find the true cause.
Item 36. Diabetes-Cystic Fibrosis.
Answer. Item 36. I feel sure even the greatest Medical Scientists would agree with me when I say - these are only symptoms; however, would they ask. "What caused the symptoms;" or does the convention of Medical Science - not allow such questions.
Item 37. Recognized as a distinct entity, Cystic Fibrosis-related diabetes - CFRD.
Answer. Item 37. One thing about the Medical Profession one has to admire - when in such a self-created corner - they will always name their way out. Then blame the Person with...
A. ...Dietary restrictions are not recommended.
Item 39. Osteoporosis can be prevented although adverse effects can be an issue.
Answer. Item 39. Then suggest albeit unwittingly - if the right one does not get you then the left one will.
Item 41. Sinus infections are treated by prolonged courses of antibiotics.
Answer. Item 41. Is this really just or simply a symptom of Cystic Fibrosis; or is it saying something quite different.
Item 42. Other chronic changes within the nasal passages...
Answer. Item 42. ... Is this offering more clues.
Item 44. Nasal inflammation.
Answer. Item 44. Surely, this holds so much information to which we can look back in history for the answer - although I no longer have the documented proof. Jean-Martin Charcot had valuable information...
A. ...Although somewhat overlooked or the wrong side of history for being too advanced or profit threatening - may well in reality have been one of the greatest thinkers of his time...
B. Jean-Martin Charcot;29 November 1825 - 16 August 1893 was a French neurologist and professor of anatomical pathology...
C. He is known as; "the founder of modern neurology" and his name has been associated with at least 15 medical eponyms, including: Charcot–Marie–Tooth disease and Charcot disease - better known as amyotrophic lateral sclerosis, motor neurone disease, or Lou Gehrig disease.
D. Charcot has been referred to as; "the father of French neurology and one of the world's pioneers of neurology."
E. His work greatly influenced the developing fields of neurology and psychology; modern psychiatry owes much to the work of Charcot and his direct followers.
F. He was the "foremost neurologist of late nineteenth-century France" and has been called "the Napoléon of the neuroses..."
G. In addition - was reported to have said to Freud. "If the Bowels are unable to evacuate then the Nasal area will suffer seemingly unrelated symptoms.
Item 45. Female infertility may be overcome by assisted reproduction technology, particularly embryo transfer techniques.
Answer. Item 45. This process is surely not to be considered Medical Science - only profiteering; as this disorder has been clearly scientifically marked as - Genetic. Thus a transfer of Genes is only tempting providence.
46. Male infertility caused by absence of the vas deferens may be overcome with testicular sperm extraction (TESE), collecting sperm cells directly from the testicles.
Answer. Item 46. If we accept this then I would be tempted to ask in no uncertain terms of the Scientists writer of such data. "What caused the absence of the Van Deferens."
A. Does this process in item 46. TESE not fit into - Answer. 45.
47. Intracytoplasmic Sperm Injection can be performed.
A. Intracytoplasmic Sperm Injection - ICSI, is an in vitro fertilization procedure in which a single sperm is injected directly into an egg.
Answer. Item 47. Moreover does this process ICSI not fit into - Answer. 45.
A. With an addition. "If the sperm is from a donor - does the Mothers Body Chemistry and Genetic Donation to the Child not have an effect on the formation of her Baby.
49. It is unclear if taking antioxidants affects outcomes.
Answer. Item 49...
A. Antioxidants are manufactured or natural substances that may prevent or delay some types of cell damage.
B. Antioxidants are found in many foods, including fruits and vegetables.
C. They are also available as dietary supplements.
D. Examples of antioxidants include - Beta-carotene.
E. Sadly this is no more than what would expected of Medical Science if one is making the smoke as just this section 11 demonstrates best call the kettle black...
F. In plain language - Black or Block the way for any other Health Care Practitioner from working with a Person with a Mysterious to the Medical Profession illness in order that they are able to continue to profit nicely from continual failure.
A. The prognosis for Cystic Fibrosis has improved due to earlier diagnosis through screening, better treatment and access to health care.
B. In 1959, the median age of survival of Children with Cystic Fibrosis in the United States was six months.
C. In 2010, survival is estimated to be 37 years for women and 40 for men.
D. In Canada, median survival increased from 24 years in 1982 to 47.7 in 2007.
E Of those with Cystic Fibrosis who are more than 18 years old as of 2009, 92% had graduated from high school, 67% had at least some college education, 15% were disabled and 9% were unemployed, 56% were single and 39% were married or living with a partner.
F. Quality of life Chronic illnesses can be very difficult to manage.
G. Cystic fibrosis is a chronic illness that affects the "digestive and respiratory tracts resulting in generalized malnutrition and chronic respiratory infections."
H. The thick secretions clog the airways in the lungs, which often cause inflammation and severe lung infections.
I. If it is compromised, it affects the quality of life of someone with Cystic Fibrosis and their ability to complete such tasks as everyday chores.
J. It is important for Cystic Fibrosis Patients to understand the detrimental relationship that chronic illnesses place on the quality of life.
K. According to Schmitz and Goldbeck (2006), the fact that Cystic Fibrosis significantly increases emotional stress on, both the individual, the family and the necessary time-consuming daily treatment routine may have further negative effects on family quality of life.
L. However, Havermans and colleagues (2006) have shown that young outpatients with Cystic Fibrosis who have participated in the CFQ-R - Cystic Fibrosis Questionnaire-Revised "rated some QOL domains higher than did their Parents."
M. Consequently, outpatients with Cystic Fibrosis have a more positive outlook for themselves.
N. Furthermore, there are many ways to improve the QOL in Cystic Fibrosis Patients. Exercise is promoted to increase lung function. Integrating an exercise regimen into the Cystic Fibrosis Patient’s daily routine can significantly improve the quality of life.
O. There is no definitive cure for Cystic Fibrosis.
P. However, there are diverse medications used, such as mucolytics, bronchodilators, steroids and antibiotics, that have the purpose of loosening mucus, expanding airways, decreasing inflammation and fighting lung infections.
Q. Conclusion. There are three issues to discuss with this section...
1. Re. Item F. It is accepted if one is only able to treat symptoms the Quality of life for Patients with Chronic illnesses - can be very difficult to manage.
A. Should this alone not prompt the question; "why do we keep saying this" and. "What are we missing."
2. Re. Item K. Although one is obliged to recognise this is more back to front medical thinking "Cystic Fibrosis significantly increases emotional stress on both the individual and the family." Is there a clue within this Medical Science is blinded too. IE. "Emotional Stress." Confirming even more back to front medical thinking.
3. Re. Item O. Confirming that wonderful get out of jail card so often used when self trapped in a corner. "There is no definitive cure for Cystic Fibrosis."
A. Epidemiology is the study and analysis of the patterns, causes and effects of health and disease conditions in defined populations.
B. It is the cornerstone of public health and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare.
C. Cystic Fibrosis is the most common life-limiting autosomal recessive disease among People of European heritage.
D. In the United States, approximately 30,000 individuals have Cystic Fibrosis; most are diagnosed by six months of age.
E. In Canada, there are approximately 4,000 People with Cystic Fibrosis.
F. Approximately 1 in 25 people of European descent and one in 30 of Caucasian Americans, is a carrier of a Cystic Fibrosis mutation.
G. Although CF is less common in these groups, approximately 1 in 46 Hispanics, 1 in 65 Africans and 1 in 90 Asians carry at least one abnormal CFTR gene.
H. Ireland has the world's highest prevalence of Cystic Fibrosis, at 1:1353.
I. Although technically a rare disease - Cystic Fibrosis is ranked as one of the most widespread life-shortening genetic diseases.
J. It is most common among nations in the Western world.
K An exception is Finland, where only one-in-80 People carry a Cystic Fibrosis mutation.
L. The World Health Organization states that "In the European Union, 1 in 2000–3000 newborns is found to be affected by Cystic Fibrosis."
M. In the United States, 1 in 3,500 Children are born with Cystic Fibrosis.
N. In 1997, about 1 in 3,300 Caucasian Children in the United States was born with Cystic Fibrosis.
O. In contrast, only 1 in 15,000 African American Children suffered from Cystic Fibrosis, and in Asian American, the rate was even lower at 1 in 32,000.
P. Cystic Fibrosis is diagnosed in Males and Females equally.
Q. For reasons that remain unclear, data has shown that Males tend to have a longer life expectancy than Females.
1. However, recent studies suggest this gender gap may no longer exist perhaps due to improvements in health care facilities.
2. While a recent study from Ireland identified a link between the Female hormone oestrogen and worse outcomes in Cystic Fibrosis.
R. The distribution of Cystic Fibrosis varies among populations.
S. The frequency of ΔF508 carriers has been estimated at 1:200 in northern Sweden, 1:143 in Lithuanians and 1:38 in Denmark.
T. No ΔF508 carriers were found among 171 Finns and 151 Saami People.
U. ΔF508 does occur in Finland, but it is a minority allele there.
V. Cystic fibrosis is known to occur in only 20 families - pedigrees in Finland. V.
Clearly: Item A. "Study and analysis of the patterns, causes and effects is the cornerstone of public health which Item B. shapes policy decisions and evidence-based practice - surely demonstrates there is a lot more work to do before the understanding of illness is able to really get started.
1. Item. I. Cystic Fibrosis is ranked as one of the most widespread life-shortening genetic diseases...
2. Q. For Reasons that Remain unclear.
3. Q. 1. Does anyone in the medical profession have an inkling as to; "why" instead of only the guesswork of. "Perhaps." .
4. Q. 2. Does this hold most serious clues.
Question. 1. What if anything can one make of this section?
Answer. 1. When one considers the introduction to this section and adds to it there are 100,000 illnesses in the world and not one of the is the cause truly known and have a cure - the words Dr. Jekyll and Mr. Hyde spring readily to Mind; Epidemiology is no more than a product of guesswork.
1. The ΔF508 mutation is estimated to be up to 52,000 years old.
2. Numerous hypotheses have been advanced as to why such a lethal mutation has persisted and spread in the human population.
3. Other common autosomal recessive diseases such as sickle-cell anaemia have been found to protect carriers from other diseases, a concept known as heterozygote advantage.
4. Resistance to the following have all been proposed as possible sources of heterozygote advantage: Cholera: With the discovery that cholera toxin requires normal host CFTR proteins to function properly, it was hypothesized that carriers of mutant CFTR genes benefited from resistance to cholera and other causes of diarrhoea.
5. Further studies have not confirmed this hypothesis.
6. Typhoid: Normal CFTR proteins are also essential for the entry of Salmonella Typhi into cells, suggesting that carriers of mutant CFTR genes might be resistant to typhoid fever.
7. No in vivo study has yet confirmed this.
A. Studies that are In Vivo - Latin for "within the living;" are those in which the effects of various biological entities are tested on whole, living organisms, usually Animals, including Humans and plants - as opposed to a partial or dead organism.
8. In both cases, the low level of Cystic Fibrosis outside of Europe, in places where both cholera and typhoid fever are endemic, is not immediately explicable.
9. Diarrhoea: It has also been hypothesized that the prevalence of Cystic Fibrosis in Europe might be connected with the development of cattle domestication.
10. In this hypothesis, carriers of a single mutant CFTR chromosome had some protection from diarrhoea caused by lactose intolerance, prior to the appearance of the mutations that created lactose tolerance.
11. Tuberculosis: Another possible explanation is that carriers of the gene could have some resistance to TB.
12. This hypothesis (guesswork) is based on the thesis that CFTR gene mutation carriers have insufficient action in one of their enzymes – arylsulphatase - which is necessary for Mycobacterium tuberculosis virulence.
13. As Mycobacterium tuberculosis would use its host’s sources to affect the individual, and due to the lack of enzyme it could not presents its virulence, being a carrier of CFTR mutation could provide resistance against Tuberculosis.
14. History Dorothy Hansine Andersen who first described Cystic Fibrosis in 1938.
15. It is supposed that Cystic Fibrosis appeared about 3,000 BC because of migration of Peoples, gene mutations and new conditions in nourishment.
16. Although the entire clinical spectrum of Cystic Fibrosis was not recognized until the 1930s, certain aspects of Cystic Fibrosis were identified much earlier.
A. Indeed, literature from Germany and Switzerland in the 18th century warned "Wehe dem Kind, das beim Kuß auf die Stirn salzig schmekt, er ist verhext und muss bald sterbe" or. "Woe to the Child who tastes salty from a kiss on the brow, for he is cursed and soon must die," thereby recognising the association between the salt loss in Cystic Fibrosis and illness.
17. In the 19th century, Carl von Rokitansky described a case of foetal death with meconium peritonitis, a complication of meconium ileus associated with cystic fibrosis. Meconium ileus was first described in 1905 by Karl Landsteiner.
A. Meconium ileus was first described in 1905 by Karl Landsteiner.
18. In 1936, Guido Fanconi published a paper describing a connection between celiac disease, cystic fibrosis of the pancreas and bronchiectasis.
19. In 1938 Dorothy Hansine Andersen published an article, "Cystic Fibrosis of the Pancreas and Its Relation to Celiac Disease: a Clinical and Pathological Study," in the American Journal of Diseases of Children.
20. She was the first to describe the characteristic Cystic Fibrosis of the pancreas and to correlate it with the lung and intestinal disease prominent in Cystic Fibrosis.
21. She also first hypothesized that Cystic Fibrosis was a recessive disease and first used pancreatic enzyme replacement to treat affected Children.
22. In 1952. Paul di Sant’Agnese discovered abnormalities in sweat electrolytes; a sweat test was developed and improved over the next decade.
23. The first linkage between Cystic Fibrosis and another marker (Paroxonase) was found in 1985 by Hans Eiberg, indicating that only one locus exists for Cystic Fibrosis.
24. In 1988 the first mutation for CF, ΔF508 was discovered by Francis Collins, Lap-Chee Tsui and John R. Riordan on the seventh chromosome.
25. Subsequent research has found over 1,000 different mutations that cause CF.
26. Because mutations in the CFTR gene are typically small, classical genetics techniques had been unable to accurately pinpoint the mutated gene.
27. Using protein markers, gene-linkage studies were able to map the mutation to chromosome 7. Chromosome-walking and -jumping techniques were then used to identify and sequence the gene.
28. In 1989. Lap-Chee Tsui led a team of researchers at the Hospital for Sick Children in Toronto that discovered the gene responsible for Cystic Fibrosis.
29. Cystic fibrosis represents a classic example of how a human genetic disorder was elucidated strictly by the process of forward genetics.
30. Conclusion... Genes are back to front thinking for in this instance; they are clearly only symptoms of an as yet undiagnosed disorder - that is, as yet, not so difficult for a Person to live with.
A. As clearly demonstrated in item 30.
31. If one is able to accept item 29 with its, "elucidate by the process of forward genetics" and in turn dismiss my comments - "this illness is not genetic" and then apply some somewhat far fetched and lateral - sideways, thinking.
A. To "elucidate" is to make something clear that was formerly murky or confusing and it is perfectly clear how the modern term got that meaning. "Elucidate" traces to the Latin term lucidus, which means "lucid." "Lucidus" in turn descends from the verb lucēre, meaning "to shine."
B. If then we are open Minded sufficiently and able to time travel, one can surely see one of the most troubling of symptoms with this mysterious disorder may well be a throw back from millions of years of Forward Genetics at work.
Question. 1. I have supported you in all the papers you have written, despite the possibility of opening myself up to extreme ridicule and not just because I agree with everything you say, only because someone has to ensure you keep the checks and balances into constant effect and are not being Psychotic and therefore Delusional. - However this bit about a Genetic Throwback is just about the worst ever?
A. Please take me out of my misery, and explain your rational even if you are unable to demonstrably prove it?
Answer. 2. Seen beautifully in Fish - the mucus we often see is no more than a Protection.
Question. 3. Please do not patronize me - get on with it, then I can laugh?
A. In the meantime perhaps you could fudge your way through this information?
Answer. 3. We could conclude the most serious possibility - a Child born with Cystic Fibrosis is in reality protecting itself.
Question. 4. Please answer my questions?
Answer. 4. Are we not doing just that as the comments made are part of the questions and answers.
Answer. 4. Perhaps the slime is a Protection against the cold water, the salt of the sea or even predators - my fishy knowledge is not that great or that ancient.
1. In addition has this been masked by medical science inability to understand sufficiently the cutely named... Cystic Fibrosis and the skin of a fish - covered by a fine epidermis or outer skin layer: where each scale fits into its own little pocket of epidermis is no more than Cystic Fibrosis inside out.
2. The skin contains glands emitting mucus which keeps the scales slippery and flexible and also acts as an anti-septic, protecting the fish from bacterial infection.
Question 5. Surely there is much more than this to support your preposterous suggestion?
Answer. 5. In order to be a sure as we can. I have carried out some research...
A.Slime in the result of glycol-proteins that are produced in the epidermis and combine with water to create mucus.
B.One of the obvious functions of slime is that it reduces drag by coating the irregular surface of the scales, thus enabling the fish to slip easily through its environment.
C.The slime also affords the fish protection against surface invaders like fungi, bacteria and ectoparasites.
D.The slime contains medicinal qualities that are soothing to open wounds.
E.It is so effective that medical researchers are working feverishly to isolate the slime’s active ingredients in an attempt to find applications for human infections.
F.Another vitally important function of slime in fish is that it aids their balance of essential electrolytes by forming a two-way selective surface that maintains a livable osmoregulatory filter.
1.Osmoregulation is the active regulation of the Osmotic pressure of an organism's body fluids to maintain the homeostasis of the organism's water content; that is, it maintains the fluid balance and the concentration of electrolytes (salts in solution) to keep the fluids from becoming too diluted or too concentrated.
G.Fish exchange respiratory gases across their skin and slime actually enhances the gas exchange efficiency across this surface.
H.Some fish slimes contain toxins that either immobilize their prey or give them protection from predators.
I.There are species that are said to have such strong toxins in their slime that a shark bite is stalled in mid-chomp.
J.Some fish are known to use slime to create nests for their young and others actually secrete copious amounts of protein-rich slime as food for their offspring.
K.In response to pending drought, African Lungfishes burrow into the soil and secret mega amounts of slime, resulting in the formation of a protective coating called a cocoon that allows them to survive until the rains reappear.
M.Colorful Caribbean Parrotfish ensure their safety as they settle down in the evenings by secreting a slime balloon around their bodies that alert them to the approach of a potential predator.
N. Some fish eat their own slime and some cultures use fish slime as an effective glue.
Question. 1.Ok Ok you have made your point I must confess I never saw that coming?
Answer. 1.I confess as well. I did not see the connection until I was midway through what I thought was the final edit and reached Genetics - there was something that jumped out at me - yet I could not tell you just what it was.
A. Although it was quite clear it fitted in the Evolution section rather than genetic.
Question. 2.Will this information enhance the ability of effective treatment from Talking Cures point of view?
A. is there anything in your findings that enhances the understanding of the real cause of Cystic Fibrosis?
Answer. 2. Yes I feel it would; however it would be better if the Person was not made privy to this information - best if we guide them to find this Mind stored information and if it is of value to them, they will.
A. There is one point in this information that for me spells out and confirms everything we have discussed within Item B; "reduces drag." on the face of it quite meaningless until one adds extremely pertinent information to it....
1. We all know how wonderfully helpful mothers and well meaning People are when a Mother to be is in the advanced stages of Pregnancy - let us say simply. "It will be the worst pain you will ever feel in your life." But when you see the Baby you will soon forget this.
2. And of course this happens - or so we prefer to think.
3. Lets us now travel back in time to 1917 and with many young mothers having the same wonderful and supporting advise at the most important point in her life - the reason we are here, to procreate.
4. And Generation after generation - say Five expectant Mothers went through this; it does not take a degree in medical advice to see - just one of them one of them will be is such fear of her Child not passing through her Pelvic Girdle-Vaginal Canal and Through her Vaginal opening, without the great Pain she has been Hypnotised into believing.
5. Subconsciously or in the depths of her Brain if one is still unable to accept there is a Mind. She without realising alters her entire body chemistry to make the Child slide through with less Pain than she has been throughout her life if not just her time of Confinement - educated to expect.
6. It then takes a lateral thinking Mind as mine to see during the Childs time in the womb it will only survive with the greatest degree of Integrity and Wisdom it is able to muster.
7. When born it will have no knowledge of this process thus will demonstrate to the world in order for them to understand and stupidity of medical science is only able to stand helplessly by but wonderfully able to give the Child a name - Cystic Fibrosis.
And then stand back to admire their work and proudly proclaim...
"...There is no known cause and no known cure."
Research Gene therapy.
A. Gene therapy has been explored as a potential cure for Cystic Fibrosis.
B. Results from trials have shown limited success as of 2013.
C. A small study published in 2015 found a small benefit.
D. The focus of much Cystic Fibrosis gene therapy research is aimed at trying to place a normal copy of the CFTR gene into affected cells.
E. Transferring the normal CFTR gene into the affected epithelium cells would result in the production of functional CFTR in all target cells, without adverse reactions or an inflammation response.
F. Studies have shown that to prevent the lung manifestations of Cystic Fibrosis, only 5-10% the normal amount of CFTR gene expression is needed.
G. Multiple approaches have been tested for gene transfer, such as liposomes and viral vectors in animal models and clinical trials.
H. However, both methods were found to be relatively inefficient treatment options.
I. The main reason is that very few cells take up the vector and express the gene, so the treatment has little effect.
J. Additionally, problems have been noted in cDNA recombination, such that the gene introduced by the treatment is rendered unusable.
K. There has been a functional repair in culture of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of Cystic Fibrosis Patients.
L. Conclusion... Let us rewrite the above in a more concise manner:
1. Gene therapy having been explored as a potential cure for Cystic Fibrosis has been shown to have limited success with very small benefit.
2. Trying to place a normal copy of a Gene into an already damaged Body - without adverse reactions or an inflammation response, it became clear - as few cells take up the vector and express the gene, the treatment has little effect. To such an extent, the gene introduced by the treatment is rendered unusable.
A. When you write the above in such a concise manner it does tend to expose just how much Medical Science attempts and indeed does hide how little they know in so many words as your papers clearly demonstrate?
B. As in Conclusion Items. 1 and 2. Do you know why this is so?
Answer. 1. This extract has most serious clues within. "To such an extent the gene introduced by the treatment is rendered unusable."
A. It must be said when a Child is born ill there is a desire in the absence of understandings as to how and why illness is caused to give it a label - which must be Blindly pursued - in this case Genetics as the cause.
B. Surely, one does not have to be a medical scientist to be aware - a Child in the Womb Doubles in Size; in a very short space of time...
C. ...Having just been born - continues the process; albeit as a slower rate.
D. Thus we can conclude when a Gene is entered into a Childs Body that is replicating so fast - the Body Chemistry almost does not even see the injected Genes as an intruder.
E. The reason for this - the Childs Body Chemistry is already from the time in the Womb - naturally or unnaturally; both Toxic and Caustic.
F. If only from Mothers Body Chemistry and it will and must take the Child some nine months to a year to cleanse itself of this toxic compound - for to attempt to achieve this quicker will result in illness or death of which the Mind is clever enough to know.
A. A number of small molecules that aim at compensating various mutations of the CFTR gene are under development.
B. One approach is to develop drugs that get the ribosome to overcome the stop codon and synthesize a full-length CFTR Protein.
C. About 10% of Cystic Fibrosis result from a premature stop codon in the DNA, leading to early termination of Protein synthesis and truncated (shorten - something by cutting off the top or the end, Proteins.
D. These drugs target nonsense mutations such as G542X, which consists of the amino acid glycine in position 542 being replaced by a stop codon.
E. Aminoglycoside antibiotics interfere with Protein synthesis and error-correction.
F. In some cases, they can cause the cell to overcome a premature stop codon by inserting a random Amino Acid, thereby allowing expression of a full-length Protein.
G. The aminoglycoside gentamicin has been used to treat lung cells from Cystic Fibrosis Patients in the laboratory to induce the cells to grow full-length Proteins.
H. Another drug targeting nonsense mutations is ataluren, which is undergoing Phase III clinical trials as of October 2011.
I. It is unclear as of 2014 if ursodeoxycholic acid is useful for those with Cystic Fibrosis-related liver disease.
1. Whether one desires to stop or encourage - Protein or Amino Acid production pales into insignificance to knowing or guessing what amounts to due process of these two Body Chemicals within this illness as instructed by the Mind.
2. For if, one does not understand this process of Mind instructed Body Chemistry - encouraging or allowing expression of a full-length Protein will only bring tears for all concerned.
3. However, it must also be recognised we must not stop trying to understand illness through research.
A. Much use of the word Fibrosis is made within this paper - many times when knowing when unable to answers complex questions, at all; let alone simply; Medical Science will change the name of an earlier misunderstood illness in order to meet more funding requirements?
B. Is there perhaps an important section or contribution you are able to add that may just assist in the eventual understanding of this mysterious set of ever changing symptoms?
A. Thank you - yes there is and it not only leaves one to ponder. "Is Cystic Fibrosis actually created by Medical Science themselves and as of yet they are blissfully by their own science thus blinded or unaware of the possibility.
B. Moreover why is it - especially when the Child grows enough to comprehend life with its natural intelligence, with all of the perceived might of medical wisdom unable to offer even long-term management let alone a cure that will give a Person the Fundamental Right of a long happy healthy life...
C. May we explore...
A. Pulmonary Toxicity is the medical name for side effects on the lungs.
B. Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy).
C. Other - non-medical causes of pulmonary toxicity can be chemical compounds and airborne particulate matter.
Pulmonary inflammation or Fibrosis.
A. Pulmonary fibrosis - literally "scarring of the lungs" is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems.
B. Scar formation, the accumulation of excess fibrous connective tissue - the process called fibrosis, leads to thickening of the walls and causes reduced Oxygen supply in the Blood.
C. As a consequence - Patients suffer from perpetual shortness of breath.
D. In some Patients the specific cause of the disease can be diagnosed, but in others the probable cause cannot be determined, a condition called idiopathic Pulmonary Fibrosis.
E. There is no known cure for the scars and damage in the lung due to pulmonary fibrosis.
Adult respiratory distress syndrome.
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