Crohn's Disease Explored Explained Understood?
Including: Irritable Bowel Syndrome. Small Intestinal Bacterial Overgrowth. Hirscprung Disease.
One may term this as hiding from the truth as we all appear to do - when mysterious illness strikes.
This Paper is as much of what is reasonable to consider - as it is a matter of fact...
It is also combined information from Wikipedia and a number of professional sources.
Therefore it may contain a number of repeats - giving rise to different opinions and or conflicting information; perhaps therefore, this particular set of mysterious and distressing symptoms, demands such scrutiny.
Moreover, for a Medically qualified Person considered as. Anecdotal - a posh word for storytelling.
If in reading this paper my writing appears to be like a foreign language or even rambling.
Consider reading this paper - not as a book; take some time to comprehend the contents.
Where I would like to think and feel sure, it will make sense?
So often, we read or hear in detail. "What" (description or symptoms) of an illness - but rarely if ever does anyone take the time to truly explain...
"...WHY," or how it is really caused...
...this paper is designed to answer many of the questions - we are so often left with.
Where many times we have the questions and no answers - or the answers and not the questions.
If I have unwittingly left anything out or not satisfactorily answered, please email (address at the end of this page) and I will include it in this Paper at the earliest opportunity.
Please include item number or a copy and paste if possible - of the item that is not clear.
Did we not all struggle as a Child to learn many things we now through the experience of life - are now extremely competent with.
No apology if offered if discussions are repeated within this paper.
The understanding for this, nothing is more repeating than illness that is there every day of one's life and - despite treatments not only does not get better or have a satisfactory explanation/understanding.
Moreover often becomes worse, as Medical Science continues to write Scientifically Proven Papers about illness; in a confusing, repeating strange to many language/words or description in a manner that confuses everyone - and ultimately even themselves!
The first thing in the process of answering this is, for any one suffering, it is clear...
"...New understandings are required about illness..."
Far too many times I have heard from People. "If Doctors cannot Cure me how can a Person not medically qualified."
...making it appear the existing quality medical education is the same worldwide?..
If on reading this or any of Talking Cures understanding of illness one gets the impression...
....I am angry...
...then please believe it; because in 2016. People are not only not recovering from any illness - so often the treatments make them worse and no one knows why or it appears. Cares.
One could also be forgiven for thinking I am against:
2. The Medical Profession.
3. Medical Scientists.
4. Medical Researchers.
5. Alternative Medicine.
6. Complimentary medicine.
The reality is I am a staunch supporter of any Person or Institution that helps People through tough emotional and physical concerns.
I am I confess most seriously against Bad Medical Science that has never once in real terms demonstrated the cause is truly known of any illness and as a result created a cure...
= ...no more illness and no more medications.
From Talking Cures point of view and therapeutic practice - names of illness especially Medically Diagnosed recognised and Scientifically proven, are of no real value in the understanding and treatment of any illness - the only Name we should use or symptom we may label is...
"A Person is unable to achieve a Healthy and satisfactory lifestyle...”
...Or never allowed to become the Person they should have been...
Thus requires. “Specialised assistance,” in order to make sense of the presenting symptoms, the cause and reason for them - enabling automatic resolution via the Persons own immune systems and Body replication process - referred to as, the Entire Body Chemistry.
...Surely if a Person cannot be in control of self-repair when can they be in control!
To a trained Medical Mind these questions and answer updates may well appear or feel patronising - it is hoped not, as their structure is at the very. "Heart" of the success of Talking Cures as a therapeutic application and may well be a serious asset and improvement in Medical Treatment outcome success.
In order to fully appreciate this, it is helpful to consider and accept;
All of the information as to why a Person became ill in the first place and as a consequence - all of the information required for them to automatically create immune response repair is - not only contained within the confines of their Mind - it is the only information required to bring about the required Automatic Cure using their own immune systems and Body replication processes. As designed by the Mind and Body.
By creating very cleverly constructed questions - Knowing the Person is able to answer them with their own knowledge of themselves of which they are a Master and if they are unable to with my interpretations, accepted as re-education of their own information, that continues/completes on an ongoing bases; the process either returning to well-health or well-health for the very first time in their lives.
Based on the secure knowledge. "The only Person with the Integrity and Wisdom to fully Understand their illness and its cause - is the Person themselves."
There are most serious considerations as to why this process as with all illness treatment interventions - appears not to succeed...
...when the Protection created in response to early Childhood Emotional and or Physical traumas is so great the Person is unable to see the Protection and therefore unable to lower the Protection - allowing a Person to observe in a safe therapeutic environment the cause and consequences of such Protection, is the only safe way to resolve illness.
And. As a result, to gently - if one dare uses such words, lower the Protection, which will allow an immune response and an automatic alteration in ones thinking process, leading to a natural life - with comfort of Mind and Body.
These explanations are from a collection of Scientifically Proven papers in the public domain and discussion forums and are in a Question and Answer forum style.
It is important to accept I am both the Questioner, on behalf of interested Person's - as well as the Person supplying the Answers, or Responding thus in many ways, my own best critic.
Leaving one to choose the Questions and Answers that are important for a better or individual understanding of this seemingly mysterious illness.
Furthermore it is imperative one recognises; I have no medical qualifications to make such assertions as contained within my answers.
This should leave one in no doubt - it is only written because the entire medical profession since its creation, have never once produced a cure for any illness.
A life time of medication - is not to be considered a cure, only management of an ever changing and most times ever growing list of symptoms and medications.
Question. 1: Given the understanding you have no medical qualifications - are you able to explain how you can present this information regarding perhaps an illness you have no real prior knowledge of; in the way that you seem very able and comfortable with?
Answer. 1: Good question and thank you.
A. First may we understand it is the ability to work - using only the Persons Mind, with as many and constantly changing set of symptoms a Person is able to present; is at the very foundation from which I work.
B. My understanding and acceptance - everyone in the Medical Profession is doing the very best they are able with Management techniques, yet fail to truly comprehend the enormity of the constantly repeated statement. "Of the 100,000 illness recognised and diagnosed," still in 2016 there is not one definitive cure for any illness.
C. Thus I start from a piece of information where a Person - say on Facebook or LinkedIn posts a question about an illness and collect from the available sources, as much information as I am able, regarding the latest information known about the illness.
D. I then create a new web page and copy and past the information into the page.
E. From here I start the edit process of this information - yet do not attempt to understand it, in much the same way a Person with the illness may in pursuit of answers and questions.
F. Part of the edit process is to convert words that appear are used only to confuse - by research many medical publications or dictionaries, into a readable format, by providing the meaning of the word. This sometimes proves to be quite a time consuming task.
G. I then go through every word and edit out the grammatical parts that I feel could read better IE. Don't - do not. Doesn't - does not or isn't - is not and at the same time apply reference numbers to each sentence as well as colour highlights of information I feel deserves such treatment.
H. Finely - once the page is in a presentable format. I then start to comprehend the enormity of the message and make responses as required, ending with why Talking Cures feels or has proven if only to my own satisfaction, how the illness is caused.
I. Once the creation process is complete I use a number of ways to spell check the entire document - often confused by different ways of spelling the word from country to country.
J. Some forty to sixty hours later, or more depending on the amount of information - having read the document more times than I am able to count. having finely checked for best level of continuity. I take the decision it is ready to publish free of any sign up - no collection of saleable contact information or fees for all to use at their desire, or desecration.
1. After all of this there are still times when an error jumps out at me.
2. Usually at this time with a final read/edit - I am reminded; I have no Medical Qualifications and often breath a sigh of relief.
Crohn's Disease Explored Explained Understood?
Courtesy of Wikipedia, the free encyclopedia:
This article is about making 2016 sense of this Individually Symptom Presented disorder.
Regarding Person's having Crohn's Disease with many interrelated symptoms - all with unknown cause and no known cure.
Ref . 1: People with Inflammatory bowel diseases were first described by Giovanni Battista Morgagni (1682–1771) and by Scottish physician T. Kennedy Dalziel in 1913.
A. From which the diagnoses of Crohn's Disease was created.
Ref. 2: ileitis terminalis; was first described by Polish surgeon Antoni Leśniowski in 1904, although it was not conclusively distinguished from intestinal tuberculosis.
A. Terminal ileitis: A chronic inflammatory disease of the intestine involving only the end of the small intestine - the terminal ileum.
B. Crohn's Disease affects primarily the small and large intestines but which can occur anywhere in the digestive system between the mouth and the anus.
Ref. 3: In Poland, it is still called Leśniowski-Crohn's Disease - Polish: choroba Leśniowskiego-Crohna.
Ref 4: An American gastroenterologist at a New York Hospital, described fourteen cases in 1932 and submitted them to the American Medical Association under the rubric of "Terminal ileitis: A new clinical entity."
A. Rubric; In academic education terminology, means a scoring guide aimed at accurate and fair assessment to evaluate the quality of students' constructed responses - usually contain evaluative criteria and quality definitions for those criteria at particular levels of achievement and a scoring strategy which can be complex and subjective; thereby fostering understanding and indicating a way to proceed with subsequent learning/teaching and the developmental sophistication of a strategy used or the degree to which a standard has been met.
Ref 5: Later, Crohn's, along with colleagues Leon Ginzburg and Gordon Oppenheimer, published the case series as. "Regional ileitis: A pathologic - of the Body and clinical entity." And in so doing gave the name Crohn's Disease to the disorder.
A. Regional; Referring to a specific area of the body with natural or arbitrary boundaries. IE. regional Pain.
B. Abdominal Regions. The abdomen and its external surface are divided into nine regions by four imaginary planes: two horizontal, one at the level of the ninth costal cartilage - or the lowest point of the costal arch.
C. The other at the level of the highest point of the iliac crest; two vertical, through the centres of the inguinal ligaments - or through the nipples or through the centres of the clavicles or curved and coinciding with the borders of the two abdominal rectus muscles.
Ref 6: Due to the manner in which Crohn's name appeared in the alphabet, the symptoms became known in the worldwide literature - as Crohn's Disease.
Ref. 7: Crohn's Disease is not to be confused with Croan, Krone, or Crone.
Ref 8: Crohn's Disease. Crohn syndrome. regional enteritis; are Patterns of Crohn's Disease.
Ref . 9: The three most common sites of intestinal involvement in Crohn's disease are, ileum, ileocolic and colonic:
A. ileum. The ileum /ˈɪliəm/ is the final section of the small intestine in most higher vertebrates, including mammals, reptiles and birds.
B. ileocolic. The ileocolic artery is the lowest branch of the Mesentric Artery.
C. Colonic Area. The Colon is the last part of the digestive system.
1. It extracts water and salt from solid wastes before they are eliminated from the body and is the site in which flora-aided - largely bacterial fermentation of unabsorbed material occurs.
2. Unlike the small intestine, the colon does not play a major role in absorption of foods and nutrients.
3. About 1.5 litres or 45 ounces of water arrives in the colon each day.
Classification and external resources.
555 OMIM 266600.
Patient UK Crohn's disease.
Ref 10: Crohn's Disease is a type of Inflammatory Bowel Disease (IBD) that may affect any part of the gastrointestinal tract from - mouth to anus.
Ref 11: Signs and symptoms often include abdominal Pain, Diarrhoea - which may be bloody if inflammation is severe, fever and weight loss.
Ref 12: Other complications may occur outside the gastrointestinal tract and include anaemia, skin rashes, arthritis, inflammation of the eye and feeling tired.
Ref 13: The skin rashes may be due to infections as well as Pyoderma Gangrenosum or Erythema Nodosum.
A. Pyoderma Gangrenosum; presents as a rapidly enlarging, very painful ulcer.
1. The condition is not an infection (pyoderma), nor does it cause gangrene.
2. A rare superficial bullous variant of pyoderma gangrenosum may heal without leaving a scar.
B. Erythema Nodosum (EN) is an inflammatory condition characterised by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins.
1. It can be caused by a variety of conditions and typically resolves spontaneously within 30 days.
2. It is common in Young People between 12–20 years of age.
Ref 14: Bowel obstruction commonly occurs with Crohn's and those with the disease are at greater risk of Bowel Cancer.
Ref 15: Crohn's Disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals.
Ref 16: Resulting in a chronic inflammatory disorder, in which the Body's immune system attacks the gastrointestinal tract; "possibly," directed at microbial antigens.
Ref 17: While Crohn's Disease is an immune related disease, it does not appear to be an autoimmune disease - in that the immune system is not being triggered by the Body itself.
Ref 18: The exact underlying immune problem is not clear; however, it may be an immunodeficiency state.
Ref 19: About half of the overall risk is related to genetics with more than 70 genes found to be involved.
Ref 20: Tobacco smokers are two times more likely to develop Crohn's Disease than nonsmokers.
Ref 21: It also often begins after gastroenteritis.
Ref 22: Diagnosis is based on a number of findings including biopsy and appearance of the bowel wall, medical imaging and description of the disease.
Ref 23: Other conditions that can present similarly include - Irritable Bowel Syndrome and Behçet's Disease.
Ref 24: There are no medications or surgical procedures that can cure Crohn's or Behcet's Disease.
Ref 25: Treatment options can only help with symptoms, maintain remission and help prevent relapse.
Ref 26: In those newly diagnosed, a corticosteroid may be used for a brief-period of time to quickly improve the disease with another medication such as either methotrexate or a thiopurine - used to prevent recurrence.
Ref 27: An important part of treatment is the stopping of smoking - among those who do.
Ref 28: One in five People with the disease are admitted to hospital each year and half of those with the disease will require surgery for the disease at some point over a ten-year period.
Ref 29: While surgery should be used as little as possible, it is necessary to address some abscesses, certain bowel obstructions and cancers.
Ref 30: Checking for bowel cancer via colonoscopy is recommended every few years, starting - eight-years after the disease has begun.
Ref 31: Crohn's Disease affects about 3.2 per 1,000 people in Europe and North America.
Ref 32: It is less common in Asia and Africa.
Ref 33: It has historically been more common in the developed world.
Ref 34: Rates have, however, been increasing, particularly in the developing world, since the 1970s.
Ref 35: Inflammatory Bowel Disease resulted in 35,000 deaths in 2010 and those with Crohn's Disease have a slightly reduced life expectancy.
Ref 36: It tends to start in the teens and twenties, although it can occur at any age.
Ref 37: Males and females are equally affected.
A. Relating to items: 15 16 17 18 24 and 25; it is clear in their own words Medical Science for this seemingly mysterious set of SYMPTOMS May not have a clue what it is talking about.
B. Is it just possible this as many Mysterious Illnesses diagnosed as being caused by Smoking (item 20) and Tiredness (item 12) would be better understood and treated (Item 24) if the Medical Profession asked the question. "What is the cause of a Person Smoking and what are the true effects this has on the Mind and Body.
Signs and symptoms.
Ref. 38: Crohn's Disease Ulcerative Colitis Defecation. Often produce porridge-like, sometimes steatorrhea, mucus-like and with blood
A. Steatorrhea or steatorrhoea; is the presence of excess fat in faeces.
B. Stools may be bulky and difficult to flush, have a pale and oily appearance and can be especially foul-smelling.
C. An oily anal leakage or some level of fecal incontinence may occur.
Ref. 39: Tenesmus it is reported is a less common aspect of Crohn's Disease.
1. Rectal tenesmus. Latin, from Greek teinesmos, from teinein to stretch, strain is a feeling of incomplete defecation.
2. It is the sensation of inability or difficulty to empty the bowel at defecation, even if the bowel contents have already been excreted.
3. Tenesmus indicates the feeling of a residue and is not always correlated with the actual presence of residual fecal matter in the rectum.
4. It is frequently painful and may be accompanied by involuntary straining and other gastrointestinal symptoms.
5. Tenesmus has both a nociceptive and a neuropathic component and is usually accompanied by intense Patient Anxiety. (Link) Anxiety.
6. Tenesmus is a continual or recurrent inclination to evacuate the bowels, caused by disorder of the rectum or other illness.
Ref 40: Nociceptive. An aspect of PHYSIOLOGY relating to or denoting Pain arising from the stimulation of nerve cells - often as distinct from that arising from damage or disease in the nerves themselves.
Ref. 41: Neuropathic Pain; is caused by damage or disease affecting the somatosensory nervous system.
A. Neuropathic Pain may be associated with abnormal sensations called Dysaesthesia or Pain from normally non-Painful stimuli - Allodynia. (Link) Allodynia
1. Neuropathic Pain does not usually get better with common painkillers, such as paracetamol, ibuprofen and other medications.
B. Dysaesthesia; is an abnormal unpleasant sensation felt when touched, caused by damage to peripheral nerves.
C. It may have continuous and/or episodic - paroxysmal components.
1. Paroxysmal attacks or paroxysms - are a sudden recurrence or intensification of symptoms, such as a spasm or seizure.
2. These short, frequent, and stereotyped symptoms can be observed in various clinical conditions.
3. A fit, attack, or sudden increase or recurrence of symptoms - as of a disease: convulsion; a paroxysm of coughing.
4. A sudden violent emotion or action : outburst, a paroxysm of rage.
Ref. 42: Gastrointestinal People with Crohn's can have Aphthous Ulcers involving the mouth.
1. Aphthous ulcers are ulcers that form on the mucous membranes.
2. They are also called aphthae, aphthosis, aphthous stomatitis and canker sores.
3. Aphthous ulcers are typically recurrent round or oval sores or ulcers inside the mouth on areas where the skin is not tightly bound to the underlying bone, such as on the inside of the lips and cheeks or underneath the tongue.
4. They can also affect the genitalia in Males and Females.
5. Recurrent Aphthous Ulcers are mostly a minor nuisance, however they are associated with significant health problems in some People.
6. Many People with Crohn's Disease have these symptoms for years prior to the CD diagnosis.
7. The usual onset is between 15 and 30 years of age, but can occur at any age.
8. Because of the 'patchy' nature of the gastrointestinal disease and the depth of tissue involvement, initial symptoms can be more subtle than those of ulcerative colitis.
Ref. 43: Ulcerative colitis (UC) is a chronic relapsing form of Inflammatory Bowel Disease (IBD) that causes inflammation and Ulcers in the Colon.
A. Symptoms can range from mild to severe with disease onset usually occurring in young adults.
B. Its course is unpredictable but with a strong likelihood of lifelong disease.
C. The disease is a type of colitis, which is a group of diseases that cause inflammation of the colon, the largest section of the large intestine, either in segments or completely.
D. The primary symptom of active disease is diarrhoea mixed with blood.
E. UC has much in common with Crohn's Disease, another form of IBD, but unlike Crohn's Disease, UC affects only the Colon and Rectum, rather than the whole GI tract.
F. UC is an intermittent disease, with periods of exacerbated symptoms alternating with relatively symptom-free periods.
G. Although the symptoms of UC can sometimes diminish on their own, the disease usually requires treatment to go into remission.
H. UC has no known cause.
Ref. 44: People with Crohn's Disease experience chronic recurring periods of flare-ups and remission.
A. Abdominal Pain may be the initial symptom of Crohn's Disease usually in the lower right area.
B. It is often accompanied by diarrhoea, especially in those who have had surgery.
C. The diarrhoea may or may not be bloody.
D. The nature of the diarrhoea in Crohn's Disease depends on the part of the small intestine or colon involved.
Ref. 45: ileitis typically results in large-volume, watery faeces.
A. ileitis is an inflammation of the ileum, a portion of the small intestine.
Ref. 46: Crohn's ileitis is a type of Crohn's Disease affecting the ileum.
Ref. 47: ileitis is caused by the bacterium Lawsonia Intracellularis.
A. Inflammatory Bowel Disease does not associate with Lawsonia Intracellularis infection.
B. There is increasing evidence that bacterial infection of the intestinal mucosa may contribute to the pathogenesis of inflammatory bowel diseases (IBD).
C. In pigs, an obligate intracellular bacterium, Lawsonia Intracellularis (LI), was shown to cause proliferative enteropathy (PE) of which some forms display histological and clinical similarities to Human IBD.
D. Since LI-similar Desulfovibrio spp. may infect human cells, it was hypothesized - guessed, that LI might be associated with the development of Human IBD.
E. Results In Human intestinal tissue samples, PCR using LLG, 50SL27, LSA and strictly LI-specific 16SII primers, yielded either no amplicons or products with weak homology to Human genomic sequences.
F. Genetic Sequencing of these amplicons revealed no specificity for LI.
G. However, amplification of DNA with less specific 16SI primers resulted in products bearing homology to certain Streptococcus species.
H. These 16SI-amplified products were present in healthy and diseased specimens, without obvious prevalence.
I. Conclusion LI is not associated with the pathogenesis of UC or CD.
Ref 48: Whether an immunologic response to commensal bacteria such as streptococci may contribute to the chronic inflammatory condition in IBD, remained to be determined.
1. Commensal microflora - normal microflora, indigenous microbiota consists of those micro-organisms which are present on Body surfaces covered by epithelial cells and are exposed to the external environment - gastrointestinal and respiratory tract, vagina, skin, etc.
Ref 49: Colitis may result in a smaller volume of faeces of higher frequency.
Ref 50: Fecal consistency may range from solid to watery.
Ref 51: In severe cases, an individual may have more than 20 bowel movements per day and may need to awaken at night to defecate.
Ref 52: Visible bleeding in the faeces is less common in Crohn's Disease than in Ulcerative Colitis, but may be seen in the creation of Crohn's Colitis.
Ref 53: Bloody bowel movements typically come and go and may be bright or dark red in colour.
Ref 54: In the creation of severe Crohn's Colitis, bleeding may be copious.
Ref 55: Flatulence and bloating may also add to the intestinal discomfort.
Ref 56: Symptoms caused by intestinal stenosis are also common in Crohn's Disease.
A. Intestinal obstructions are usually classified according to where in the intestine the absence, blockage or narrowing is found.
B. Obstruction in the duodenum is known as duodenal atresia/stenosis.
C. Obstructions in the jejunum or the ileum are both called jejunoileal atresia/stenosis.
Ref 57: Abdominal Pain is often most severe in areas of the bowel with stenoses.
Ref 58: Persistent vomiting and nausea may indicate stenosis from small bowel obstruction or disease involving the stomach, pylorus, or duodenum.
Ref 59: Although the association is greater in the context of Ulcerative Colitis,
Ref 60: Crohn's Disease may also be associated with primary Sclerosing Cholangitis, a type of inflammation of the bile ducts.
A. Sclerosing Cholangitis (PSC) is a disease of the bile ducts that causes inflammation and obliterative - Tending or serving to obliterate, fibrosis of bile ducts inside and/or outside of the liver.
Ref 61: Perianal - situated in or affecting the area around the anus discomfort, may also be prominent in Crohn's Disease.
Ref 62: Itchiness or Pain around the anus may be suggestive of inflammation, fistulization or abscess around the anal area or anal fissure.
Ref. 63: Perianal skin tags are also common in Crohn's disease.
Ref 64: Fecal incontinence may accompany perianal Crohn's Disease.
Ref 65: At the opposite end of the gastrointestinal tract, the mouth - may be affected by non-healing sores - aphthous ulcers.
Ref 66: Rarely, the oesophagus and stomach may be involved in Crohn's Disease.
A. These can cause symptoms including difficulty swallowing (dysphagia), upper abdominal pain and vomiting.
Ref 67: Systemic Crohn's Disease, like many other chronic, inflammatory diseases, can cause a variety of systemic symptoms.
A. Among Children, growth failure is common.
B. Many Children are first diagnosed with Crohn's Disease - based on inability to maintain growth.
C. As it may manifest at the time of the growth spurt in puberty, up to 30% of Children with Crohn's Disease may have retardation of growth.
Ref 68: Fever may also be present, though fevers greater than 38.5 °C (101.3 °F) are uncommon unless there is a complication such as an abscess.
Ref 69: Among older individuals, Crohn's Disease may manifest as weight loss, usually related to decreased food intake, since individuals with intestinal symptoms from Crohn's Disease often feel better when they do not eat and might lose their appetite.
Ref 70: People with extensive small intestine disease may also have mal absorption of carbohydrates or lipids, which can further exacerbate weight loss.
Conclusion. Is it possible if (item 42) and its implications were truly understood, then (item 43 h) would no longer exist.
Extra intestinal Erythema Nodosum.
Ref 71: Extra intestinal manifestations (EIMs) of inflammatory bowel disease (IBD) are common in both ulcerative colitis (UC) and Crohn's disease (CD).
A. These manifestations can involve nearly any organ system - including the musculoskeletal, dermatologic, hepatopancreatobiliary, ocular, renal and pulmonary systems and can cause a significant challenge to physicians managing IBD patients.
B. Most IBD Patients with EIMs have colonic inflammation, although some Patients develop EIMs - prior to the onset of colonic symptoms.
C. Erythema Nodosum is a skin condition where red lumps form on the shins and less commonly the thighs and forearms.
D. Symptoms of underlying disease may be present in some Patients with Erythema Nodosum, e.g. sore throat in those with streptococcal infection.
E. Red lumps appear on the on the back of a Person with Crohn's Disease In addition to systemic and gastrointestinal involvement,
Ref 72: Crohn's Disease can affect many other organ systems.
Ref 73: Inflammation of the interior portion of the eye, known as uveitis, can cause blurred vision and eye Pain, especially when exposed to light - photophobia.
A. Inflammation may also involve the white part of the eye (sclera), a condition called episcleritis.
B. Both episcleritis and uveitis can lead to loss of vision if untreated.
Ref 74: Crohn's Disease that affects the ileum may result in an increased risk for gallstones.
Ref 75: This is due to a decrease in bile acid resorption in the ileum and the bile gets excreted in the stool.
A. As a result, the cholesterol/bile ratio increases in the gallbladder, resulting in an increased risk for gallstones.
Ref 76: Crohn's disease is associated with a type of rheumatology disease known assseronegative spondyloarthropathy.
A. This group of diseases is characterized by inflammation of one or more joints - arthritis or muscle insertions.
Conclusion. Is it also possible if item (71 B) had a beneficial Scientific Expression - then the disease could be better treated and possibly cured.
Ref 77: Enthesitis is inflammation of the entheses, the sites where tendons or ligaments insert into the bone.
A. It is also called enthesopathy, or any pathologic condition involving the entheses.
Ref 78: Arthritis in Crohn's Disease can be divided into two types.
A. The first type affects larger weight-bearing joints such as the knee - most common, hips, shoulders, wrists or elbows.
B. The second type symmetrically involves five or more of the small joints of the hands and feet.
C. Arthritis may also involve the spine, leading to ankylosing spondylitis - if the entire spine is involved, or simply sacroiliitis, if only the sacroiliac joint is involved.
1. In Medicine. Sacroiliitis is an inflammation of the sacroiliac joint.
2. Sacroiliitis is a feature of spondylarthropathies, such as ankylosing spondylitis, psoriatic arthritis, reactive arthritis or arthritis related to inflammatory bowel diseases, including Ulcerative Colitis or Crohn's Disease.
D. The symptoms of Arthritis include painful, warm, swollen, stiff joints and loss of joint mobility or function.
Conclusion. Within the two sections above there are questions not asked nor answered - yet the answer is clear to see within this section, if one sees with the Mind instead of the Eyes.
Ref 79: Pyoderma gangrenosum is a condition that causes tissue to become Necrotic.
A. Necrotic. The death of cells or tissues from severe injury or disease, especially in a localized area of the Body. Causes of necrosis include inadequate blood supply (as in infarcted tissue), bacterial infection, traumatic injury and hyperthermia.
1. Infarcted Tissue is (necrosis) caused by a local lack of oxygen, due to an obstruction of the tissue's blood supply.
B. Often causing deep ulcers that usually occur on the legs of a Person with Crohn's Disease and may also involve the skin, blood and endocrine system.
C. When they occur, they can lead to chronic wounds.
D. Ulcers usually initially look like small bug bites or papules and can progress to larger ulcers.
E. Though the wounds rarely lead to death, they can cause Pain and Scarring.
Conclusion. Sigh - if only lack of Oxygen throughout the Body was truly understood.
Ref 80: The most common type of skin manifestation, erythema nodosum, presents as raised, tender red nodules usually appearing on the shins.
Ref 81: Erythema Nodosum is due to inflammation of the underlying subcutaneous tissue and is characterized by Septal Panniculitis.
A. Septal Panniculitis. The panniculitides represent a group of heterogeneous inflammatory diseases that involve the subcutaneous fat.
B. The specific diagnosis of these diseases requires histopathologic study because different panniculitides usually show the same clinical appearance, which consists of subcutaneous erythematous nodules on the lower extremities.
1. Histopathologic Study - refers to the microscopic examination of tissue in order to study the manifestations of disease.
C. However, the histopathologic study of panniculitis is difficult because of an inadequate clinicopathologic correlation and the changing evolutionary nature of the lesions means that biopsy specimens are often taken from late-stage lesions, which results in nonspecific histopathologic findings.
Ref 82: Another skin lesion, Pyoderma Gangrenosum, is typically a painful ulcerating nodule.
A. Pyoderma Gangrenosum. is a rare skin condition that causes painful ulcers. It is usually treatable, but may take some time to heal and may leave some scarring.
Ref 83: Crohn's Disease also increases the risk of blood clots; painful swelling of the lower legs can be a sign of deep venous thrombosis, while difficulty breathing may be a result of pulmonary embolism.
Ref 84: Autoimmune hemolytic anaemia, a condition in which the immune system attacks the red blood cells, is also more common in Crohn's Disease and may cause fatigue, a pale appearance and other symptoms common in anaemia.
Ref 85: Clubbing, a deformity of the ends of the fingers, may also be a result of Crohn's Disease.
Ref 86: Crohn's Disease increases the risk of Osteoporosis, or thinning of the bones.
Ref 87: Individuals with osteoporosis are at increased risk of bone fractures.
Ref 88: People with Crohn's Disease often have anaemia due to vitamin B12, folate, iron deficiency, or due to anaemia of chronic disease.
A. The most common is iron deficiency anaemia from chronic blood loss, reduced dietary intake and persistent inflammation leading to increased Hepcidin levels, restricting iron absorption in the duodenum.
1. Hepcidin; Is a key regulator of the entry of iron into the circulation in mammals.
2. In states in which the hepcidin level is abnormally high such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption.
Ref 89: As Crohn's Disease most commonly affects the terminal ileum where the vitamin B12/intrinsic factor complex is absorbed, B12 deficiency may be seen.
A. This is particularly common after surgery to remove the ileum.
Ref 90: Involvement of the duodenum and jejunum can impair the absorption of many other nutrients including folate.
A. Duodenum - Receives partially digested food - known as chyme from the stomach and plays a vital role in the chemical digestion of chyme in preparation for absorption in the small intestine.
B. Many chemical secretions from the pancreas, liver and gallbladder mix with the chyme in the...
C. The jejunum - is the middle segment of the small intestine found between the duodenum and the ileum.
D. Most of the nutrients present in food are absorbed by the jejunum before being passed on to the ileum for further absorption.
Ref 91: If Crohn's Disease affects the stomach, production of intrinsic factor can be reduced.
Ref 92: Crohn's Disease can also cause neurological complications - reportedly in up to 15%.
A. Neurological conditions result from damage to the brain, spinal column or nerves, caused by illness or injury.
B. Many of the precise causes of neurological conditions are not yet known.
C. Neurological conditions - affect young, old, rich, poor, men, women and People from all cultures and ethnicity.
D. Some neurological conditions are life-long and People can experience onset at any time in their lives.
E. The most common of these are seizures, stroke, myopathy, peripheral neuropathy, headache and depression.
Ref 93: People with Crohn's often also have issues with small bowel bacterial overgrowth syndrome, which has similar symptoms.
Ref 94: In the oral cavity People with Crohn's may develop cheilitis granulomatosa and other forms of orificial granulomatosis, pyostomatitis vegetans, recurrent aphthous stomatitis, geographic tongue and migratory stomatitis in higher prevalence than the general population.
A. - Granulomatous Cheilitis - refers to an uncommon condition in which there is lumpy swelling of the lips.
1. It is also known as Cheilitis Granulomatosa and is part of the spectrum of orificial granulomatosis.
2. There are many different causes, such as allergy, Crohn's Disease, sarcoidosis and orificial granulomatosis.
B. Pyostomatitis Vegetans - is a rare but characteristic pustular eruption of the mouth and skin folds consistently associated with inflammatory bowel diseases such as ulcerative colitis and less commonly Crohn disease.
1. The skin disease is pyodermatitis vegetans and the mucosal disease is pyostomatitis vegetans.
C. Stomatitis - is a general term for an inflamed and sore mouth, can disrupt a Person's ability to eat, talk and sleep.
1. Stomatitis can occur anywhere in the mouth.
D. Geographic tongue, also known by several other terms, is an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface.
1. It is a common condition, affecting approximately 2–3% of the general population.
2. It is characterized by areas of smooth, red depapillation - loss of lingual papillae which migrate over time.
3. The name comes from the map-like appearance of the tongue, with the patches resembling the islands of an archipelago.
4. The cause is unknown, but the condition is entirely benign - importantly, it does not represent oral cancer and there is no curative treatment.
5. Uncommonly, geographic tongue may cause a burning sensation on the tongue, for which various treatments have been described with little formal evidence of efficacy.
Conclusion. One wonders with all of the might of Medical Science in this section alone - where the most powerful of computers would not be able to comprehend the enormity and ever changing face of these symptoms; what would happen if Medical Science had a Mind and were able to use it instead of talking as perfectly described in item 81C; such scientifically proven confusing nonsense.
Cause Risk factors.
Ref 95: Crohn's Disease is a higher risk for smokers.
Ref 96: Ulcerative Colitis has a Lower risk for smokers.
Ref 97: Age Usual onset between 15 and 30 years.
Ref 98: Peak incidence between 15 and 25 years.
Ref 99: While the exact cause is unknown, Crohn's Disease seems to be due to a combination of environmental factors and genetic predisposition.
Ref 100: Crohn's Disease is the first genetically complex disease in which the relationship between genetic risk factors and the immune system is understood in considerable detail.
A. Each individual risk mutation makes a small contribution to the overall risk of Crohn's - approximately 1:200.
B. The genetic data and direct assessment of immunity, indicates a malfunction in the innate immune system.
1. In this view, the chronic inflammation of Crohn's is caused when the adaptive immune system tries to compensate for a deficient innate immune system.
2. Innate - existing at the time of birth.
Conclusion. Reminds me of the Merry go Round we all became Giddy on during our Formative Years - Surely this is not even of Novel let alone Scientific Interest; let alone value.
Genetics Risk factors.
Ref 101: Some Genetic Mutations are associated with certain disease patterns in Crohn's Disease.
Ref 102: Appearing to demonstrate - Crohn's Disease has a genetic component.
Ref 103: Because of this, siblings of known People with Crohn's are 30 times more likely to develop Crohn's; than the general population.
Ref 104: The first mutation found to be associated with Crohn's Disease was a frame shift in the NOD2 gene - also known as the CARD15 gene, followed by the discovery of point mutations.
Ref 105: Over thirty genes have been associated with Crohn's Disease; a biological function is known for most of them.
Ref 106: For example, one association is with mutations in the XBP1 gene, which is involved in the unfolded protein response pathway of the Endoplasmic Reticulum.
A. Endoplasmic Reticulum. Is a network of membranous tubules within the cytoplasm of a eukaryotic cell, continuous with the nuclear membrane.
B. It usually has ribosomes attached and is involved in protein and lipid synthesis.
Ref 107: Other well documented genes which increase the risk of developing Crohn's Disease are: ATG16L1, IL23R, IRGM and SLC11A1.
Ref 108: There is considerable overlap between susceptibility loci for IBD and mycobacterial infections.
A. Locus is a path. The path is formed by a point which moves according to a particular rule.
B. Loci is the plural of locus.
C: Mycobacteria - are a type of germ.
1. There are many different kinds.
2. The most common one causes tuberculosis.
3. Another one causes leprosy.
4. Still others cause infections that are called atypical Mycobacterial Infections.
A. Mycobacteria Infections. Other than the tubercle bacillus sometimes infect Humans.
B. These organisms are commonly present in soil and water and are much less virulent in Humans than tuberculosis.
C. Infections with these organisms have been called atypical, environmental and non tuberculous mycobacterial infections.
5. They are not "typical," because they do not cause tuberculosis.
6. However they can still harm People, especially People with other problems that affect immunity, such as AIDS.
Ref 109: Recent genome-wide association studies have shown that Crohn’s Disease is genetically linked to Coeliac Disease.
Conclusion. And when the Genetic Gene structure of the entire body has been long documented and still the cause is not known and there are no cures - what oh what happens to the Medical Science from that point on.
Ref 110: There was a prevailing view that Crohn's Disease is a primary T cell autoimmune disorder.
A. However, a newer theory hypothesizes that Crohn's results from an impaired innate immunity.
B. The later hypothesis (guesswork) describes impaired cytokine secretion by macrophages, which contributes to impaired innate immunity and leads to a sustained microbial-induced inflammatory response in the colon, where the bacterial load is high.
C. Another theory is that the inflammation of Crohn's Disease was caused by an overactive Th1 and Th17 cytokine response.
D. In 2007, the ATG16L1 gene was implicated in Crohn's Disease, which may induce Autophagy and hinder the Body's ability to attack invasive bacteria.
1. Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress.
Ref 111: Another study has theorized (guessed) that the human immune system traditionally evolved with the presence of parasites inside the Body and that the lack thereof due to modern hygiene standards- has weakened the immune system.
A. Test subjects were reintroduced to harmless parasites, with positive response.
Conclusion. When in any scientifically proven paper one still has to use the words: "hypothesis, "theory" "hypothesizes," "May" and "therorised." Is it not fair to suggest the paper is a self defeating prophesy.
Ref 112. Current thinking is that microorganisms are taking advantage of their host's weakened mucosal layer and inability to clear bacteria from the intestinal walls, which are both symptoms of Crohn's Disease.
Ref 113. Different strains found in tissue and different outcomes to antibiotics therapy and resistance suggest Crohn's Disease is not one disease, but an umbrella of diseases related to different pathogens.
Ref 114: A number of studies have suggested a causal role is the Mycobacterium Avium subspecies Paratuberculosis (MAP), which causes a similar disease, Johne's Disease, in cattle.
Ref 115: NOD2 is a gene involved in Crohn's Disease genetic susceptibility.
Ref 116: It is associated with macrophages' diminished ability to phagocize MAP.
A. Phagocytise. To envelop and destroy bacteria and other foreign material.
Ref 117: This same gene may reduce innate and adaptive immunity in gastrointestinal tissue and impair the ability to resist infection by the MAP bacterium.
Ref 118: Macrophages that ingest the MAP bacterium are associated with high production of TNF-α.
Ref 119: Other studies have linked specific strains of Enteroadherent E. coli to the disease.
A: Enteroadherent E Coli. Despite a great expansion in Medical knowledge of the causative agents of infectious diarrhoea over the past 20 years, a significant proportion of diarrhoea cases remain undiagnosed.
B. Enteroadherent Escherichia - coli are a relatively recently identified group of enteric bacteria which have been implicated as diarrhoeal pathogens.
1. Escherichia coli. Also known as E. coli is a gram-negative, facultatively anaerobic, rod-shaped bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms - endotherms.
2. Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in their hosts and are occasionally responsible for product recalls due to food contamination.
3. These organisms, defined by their ability to adhere to human epithelial-derived tissue culture cells, have been closely studied over the past 10 years and appear to be quite heterogeneous.
A. Heterogeneous. Composed of parts of different kinds; having widely dissimilar elements or constituents:
B. Chemistry. Constitutes of a mixture - composed of different substances or the same substance in different phases, as solid ice and liquid water.
Ref 120: Adherent-invasive Escherichia coli (AIEC), as they are more common in People with CD, they have the ability to make strong bio films compared to non-AIEC strains correlating with high adhesion and invasion indices of neutrophils and the ability to block autophagy at the autolysosomal step, which allows for intracellular survival of the bacteria and induction of inflammation.
A. Inflammation drives the proliferation of AIEC and Dysbiosis in the ileum, irrespective of genotype.
1. Dysbiosis. Is when the bad guys take over.
2. It was first identified in the early 20th century and was awarded a Nobel Prize.
3. It essentially means there is an imbalance of microbial colonies.
B. AIEC strains replicate extensively into macrophages inducing the secretion of very large amounts of TNF-α.
C. Mouse studies have suggested some symptoms of Crohn's Disease, Ulcerative Colitis and Irritable Bowel Syndrome have the same underlying cause.
D. Biopsy samples taken from the colons of all three Patient groups - were found to produce elevated levels of a Serine Protease.
E. Experimental introduction of the Serine Protease into mice has been found to produce widespread Pain associated with Irritable Bowel Syndrome, as well as Colitis, which is associated with all three diseases.
1. Serine Protease. Or Serine Endopeptidase's are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the enzyme's active site.
2. They are found ubiquitously in both Eukaryotes and Prokaryotes.
3. Ubiquitous - existing or being everywhere, especially at the same time.
4. Eukaryotes. Belong to the taxon Eukarya or Eukaryota.
A. The defining feature that sets eukaryotic cells apart from prokaryotic cells (Bacteria and Archaea) is that they have membrane-bound organelles, especially the nucleus, which contains the genetic material and is enclosed by the nuclear envelope.
5. Prokaryotes. A Prokaryote is a single-celled organism that lacks a membrane-bound nucleus (karyon), mitochondria, or any other membrane-bound organelle.
1. The word prokaryote comes from the Greek πρό (pro) "before" and καρυόν (karyon) "nut or kernel".
2. Prokaryotes can be divided into two domains, Archaea and Bacteria.
Ref 121: Regional and temporal variations in those illnesses follow those associated with infection with the Protozoan Blastocystis.
Ref 122: The common Protozoan Parasite Blastocystis hominis - that lives in the gut has been associated with Irritable Bowel Syndrome and it may be that Blastocystis Hominis will turn out to be the cause of IBS in many Patients.
A. Better understanding of the biology and pathogenicity of Blastocystis Hominis has only emerged in the last 10 years.
B. The Blastocystis Hominis parasite can be hard to test for, hard to - but not impossible to treat.
C. Nevertheless for many People with IBS, exploring whether their IBS and its attendant Mental and Emotional symptoms may be caused by Blastocystis Hominis is definitely a path worth pursuing.
1. Blastocystis Hominis. Is a microscopic organism that may be found in the stools of healthy People who are not having any digestive symptoms.
2. Blastocystis Hominis is also sometimes found in the stools of People who have diarrhoea, abdominal pain or other gastrointestinal problems.
3. Researchers do not yet fully understand the role that Blastocystis Hominis plays, if any, in causing an infection.
4. Certain forms of Blastocystis Hominis may be more likely to be linked to an infection with symptoms.
5. Sometimes, Blastocystis simply lives in a Person's digestive tract without causing harm.
D. There is every possibility that a Person may be able to cure themselves of IBS, simply by taking some anti-protozoan drugs that will kill off the Blastocystis Hominis parasite in the gut.
Ref 123: The "cold-chain" hypothesis (guesswork) is that Psychrotrophic Bacteria such as Yersinia and Listeria species contribute to the disease.
1. Psychrotrophic Bacteria; are bacteria that are capable of surviving or even thriving in a cold environment.
2. They provide an estimation of the product's shelf life.
3. Also they can be found in soils, in surface and deep sea waters, in Antarctic ecosystems, and in foods.
4. They are responsible for spoiling refrigerated foods.
5. A Statistical correlation was found between the advent of the use of refrigeration in the United States and various parts of Europe and the rise of the Disease.
Conclusion. Items 112 and 113 carry sufficient clues to write a book about this disorder, whilst 122D confirms so and also demonstrates Medical Science is lost in the Academic Mathematical Numbers
Ref 124: There is an apparent connection between Crohn's Disease, Mycobacterium, other pathogenic bacteria and genetic markers.
1. Mycobacterium. is a genus of Actinobacteria, given its own family, the Mycobacteriaceae.
A. Actinobacteria include some of the most common soil life, freshwater life and marine life, playing an important role in decomposition of organic materials.
2. The genus includes pathogens known to cause serious diseases in mammals, including tuberculosis
Ref 125: In many individuals, genetic factors predispose individuals to Mycobacterium avium subspecies - paratuberculosis infection.
1. Paratuberculosis infection. Paratuberculosis or Johne's disease is a contagious, chronic and sometimes fatal infection that primarily affects the small intestine of ruminants.
2. It is caused by the bacterium Mycobacterium Avium subspecies paratuberculosis.
A. Mycobacterium Avium complex, or MAC, is a type of bacterial infection that can cause life-threatening symptoms in People who have compromised immune systems.
B. In People with advanced HIV disease, MAC usually does not involve the lungs.
C. Instead, it causes disease in other organs.
D. This bacterium then produces Mannins, which protect both itself and various bacteria from Phagocytosis, which causes a variety of secondary infections.
1. Mannins. Try as I might albeit not exhaustively - I was unable to improve on the understanding of this word as all references appear they have simply copied the explanation from another source and blindly accepted its explanation.
2. . Phagocytosis, process by which certain living cells called phagocyte's ingest or engulf other cells or particles.
3. The phagocyte may be a free-living one-celled organism, such as an amoeba, or one of the Body cells, such as a white blood cell.
Ref 126: Still, this relationship between specific types of bacteria and Crohn's disease remains unclear.
Conclusion. As item 126 clearly demonstrates - nothing of real value is known, is it not time post the Noble Prize desire to start to look at the failure of Modern Scientific Medicine, instead of bathing in the glory of past failures.
Ref 127: The increased incidence of Crohn's Disease in the industrialized world indicates an environmental component.
Ref 128: Crohn's Disease is associated with an increased intake of animal protein, milk protein and an increased ratio of omega-6 to omega-3 polyunsaturated fatty acids.
Ref 129: Those who consume vegetable proteins appear to have a lower incidence of Crohn's Disease.
Ref 130: Consumption of fish protein has no association.
Ref 131: Smoking increases the risk of the return of active disease or flares.
Ref 132: The introduction of hormonal contraception in the United States in the 1960s is associated with a dramatic increase in incidence and one hypothesis (guesswork) is that these drugs work on the digestive system in ways similar to smoking.
Ref 133: Prescribed Isotretinoin is associated with Crohn's Disease.
A. Isotretinoin (INN), also known as 13-cis retinoic acid, is an oral pharmaceutical drug primarily used to treat severe nodular acne.
B. Rarely, it is also used to prevent certain skin cancers - squamous-cell carcinoma and in the treatment of other cancers.
C. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease and lamellar ichthyosis.
D. It is a retinoid, meaning it is related to vitamin A and is found in small quantities naturally in the Body.
E. Its isomer, tretinoin, is also an acne drug.
1. An isomer (/ˈaɪsəmər/; from Greek ἰσομερής, isomerès; isos = "equal", méros = "part") is a molecule with the same molecular formula as another molecule, but with a different chemical structure.
2. Tretinoin is the pharmaceutical form of retinoic acid. One of several retinoids, it is the carboxylic acid form of vitamin A and is also known as all-trans retinoic acid
3. Isomers contain the same number of atoms of each element, but have different arrangements of their atoms.
F. Isotretinoin is primarily used as a treatment for severe acne.
1. The most common adverse effects are a transient worsening of acne - lasting 2–3 weeks, dry lips (cheilitis), dry and fragile skin and an increased susceptibility to sunburn.
G. Uncommon and rare side effects include muscle aches and pains - myalgias and headaches.
H. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.
I. In the United States a special procedure is required to obtain the Pharmaceutical.
J. In most other countries a consent form is required which explains these risks.
K. Women taking Isotretinoin must not get pregnant during and for 1 month after isotretinoin therapy.
L. Sexual abstinence, or effective contraception is mandatory during this period.
Ref 133: Although stress is sometimes claimed to exacerbate Crohn's Disease, there is no concrete evidence to support such claims.
Ref 134: Dietary micro particles, such as those found in toothpaste, have been studied as they produce negative effects on immunity, but they were not consumed in greater amounts in Patients with Crohn's Disease.
Conclusion. Much could be made of this section - however Medical Skies sums it up rather nicely in Item 133.
Ref 135: Pathophysiology or Physiopathology is a convergence of pathology with physiology.
1. Pathology is the medical discipline that describes conditions typically observed during a disease state.
2. Physiology is the biological discipline that describes processes or mechanisms operating within an organism.
Ref 136: Pathophysiology of Crohn's Disease and Ulcerative Colitis by way of Cytokine response Associated with Th17.
Ref 137: Vaguely associated with Th2 During a colonoscopy where biopsies of the colon are often taken to confirm the diagnosis.
Ref 138: Certain characteristic features of the pathology seen point toward Crohn's Disease; shows a transmural pattern of inflammation, meaning the inflammation may span the entire depth of the intestinal wall.
Ref 139: Ulceration is an outcome seen in highly active disease.
Ref 140: There is usually an abrupt transition between unaffected tissue and the ulcer - a characteristic sign known as skip lesions.
Ref 141: Under a microscope, biopsies of the affected colon may show mucosal inflammation, characterized by focal infiltration of neutrophils, a type of inflammatory cell, into the epithelium.
Ref 142: This typically occurs in the area overlying lymphoid aggregates.
Ref 143: These neutrophils, along with mononuclear cells, may infiltrate the crypts, leading to inflammation - crypititis or abscess - crypt abscess.
Ref 144: Granulomas, aggregates of macrophage derivatives known as giant cells, are found in 50% of cases and are most specific for Crohn's Disease.
Ref 145: The granulomas of Crohn's Disease do not show "causation;" on microscopic examination characteristic of granulomas associated with infections, such conditions characteristic of tuberculosis, in which diseased tissue forms a firm, dry mass cheese like in appearance.
Ref 146: Biopsies may also show chronic mucosal damage, as evidenced by blunting of the intestinal villi, atypical branching of the crypts and a change in the tissue type - metaplasia.
Ref 147: One example of such metaplasia, Paneth cell metaplasia, involves development of Paneth cells - typically found in the small intestine and a key regulator of intestinal microbiota in other parts of the gastrointestinal system.
Conclusion. Whilst the word "Psychological" is only to be seen as a symptom - its exclusion from item 135 is most seriously noticed by its absence.
Ref 148: The diagnosis of Crohn's Disease can sometimes be challenging and a number of tests are often required to assist the physician in making the diagnosis.
Ref 149: Even with a full battery of tests, it may not be possible to diagnose Crohn's Disease with complete certainty; a colonoscopy is approximately 70% effective in diagnosing the disease, with further tests being less effective.
Ref 150: Disease in the small bowel is particularly difficult to diagnose, as a traditional colonoscopy allows access to only the colon and lower portions of the small intestines; introduction of the capsule endoscopy aids in endoscopic diagnosis.
Ref 151: Multinucleated Giant Cells Are a common finding in the lesions of Crohn's Disease and are less common in the lesions of lichen nitidus.
A. Multinucleated giant cells. The current situation is intended to provide insight into the current state of understanding regarding the molecular and cellular mechanisms underlying the formation and function of various types of multinucleated giant cells.
B. These recently identified factors together with the well-known osteoclast receptor, αvβ3, may serve as potential therapeutic targets for the modulation and inhibition of multinucleated giant cell formation and function.
C. Further studies on intracellular and intercellular signaling mechanisms modulating multinucleated giant cell formation and function are necessary for the identification of therapeutic targets as well as a better understanding of giant cell biology.
Ref 152: Endoscopic image of Crohn's Colitis showing deep ulceration, with a CT scan shows Crohn's Disease in the fundus of the stomach
A. An Endoscopic biopsy will show granulomatous inflammation of the colon in a case of Crohn's Disease.
Ref 153: Section of colectomy shows transmural inflammation Resected ileum for a Person with Crohn's disease and a classification distribution of gastrointestinal Crohn's Disease.
Ref 154: Crohn's Disease is one type of inflammatory bowel disease - IBD.
A: It typically manifests in the gastrointestinal tract and can be categorized by the specific tract region affected.
B. A disease of both the ileum - the last part of the small intestine that connects to the large intestine and the large intestine, Ileocolic Crohn's Disease accounts for fifty percent of cases.
C. Crohn's ileitis, manifest in the ileum only and accounts for thirty percent of cases, while Crohn's colitis, of the large intestine, accounts for the remaining twenty percent of cases and may be particularly difficult to distinguish from ulcerative colitis.
Conclusion. Items 148 and 9 as written by Medical Science themselves clearly demonstrate there is no more than guesswork in the diagnosis of this disorder - this surely cannot be supported as Scientific. Moreover item 151 C is suggestive the reason behind this is purely financial and nothing to do with true science.
Ref 155: The gastroduodenal artery is a small blood vessel in the abdomen.
A. It supplies blood directly to the pylorus - distal part of the stomach and proximal part of the duodenum.
B. And indirectly to the pancreatic head via the anterior and posterior superior pancreaticoduodenal arteries.
Ref 156: Crohn's Disease causes inflammation in the stomach and first part of the small intestine, called the duodenum.
Ref 157: Jejunoileitis causes spotty patches of inflammation in the top half of the small intestine, called the jejunum.
Ref 158: The disease can attack any part of the digestive tract, from mouth to anus.
A. However, individuals affected by the disease rarely fall outside these three classifications, with presentations in other areas.
Ref 159: Crohn's Disease may also be categorized by the behaviour of disease as it progresses.
Ref 160: These categorizations formalized in the Vienna classification of the disease.
A. There are three categories of disease presentation in Crohn's Disease:
Stricturing Disease - causes narrowing of the bowel that may lead to bowel obstruction or changes in the calibre of the faeces.
Penetrating Disease - creates abnormal passageways - fistulae, between the bowel and other structures, such as the skin.
Inflammatory Disease - or non Stricturing, non penetrating disease, causes inflammation without causing strictures or fistulae.
Conclusion. And all of this very eloquent explanation tells us nothing of value - other than the blind skill of constantly making name changes by Medical Science.
Ref 161: A colonoscopy is the best test for making the diagnosis of Crohn's Disease, as it allows direct visualization of the colon and the terminal ileum, identifying the pattern of disease involvement.
Ref 162: On occasions, the colonoscope can travel past the terminal ileum, but it varies from Person to Person.
Ref 163: During the procedure, the gastroenterologist can also perform a biopsy, taking small samples of tissue for laboratory analysis, which may help confirm a diagnosis.
Ref 164: As 30% of Crohn's Disease involves only the ileum, cannulation of the terminal ileum is required in making the diagnosis.
A. Intravenous (IV) Cannulation is a technique in which a cannula is placed inside a vein to provide venous access.
B. Venous access allows sampling of blood as well as administration of fluids, medications, parenteral nutrition, chemotherapy and blood products.
Ref 165: Finding a patchy distribution of disease, with involvement of the colon or ileum, but not the rectum, is suggestive of Crohn's Disease, as are other endoscopic stigmata.
A. Endoscopic Stigmata - meaning is a sign of a recent clinically induced haemorrhage which is recorded as a prediction of further risk of bleeding and guide management.
Ref 166: The utility of capsule endoscopy for this, however, is still uncertain.
Ref 167: A "cobblestone" like appearance is seen in approximately 40% of cases of Crohn's Disease upon colonoscopy, representing areas of ulceration separated by narrow areas of healthy tissue.
Conclusion. Is it not fair to suggest as Item 161 demonstrates and item 165 A confirms - nothing is known and all investigations are only to relieve the anxiety of the know very little clinicians, based on such poor science that will not include the Mind as item 162 confirms.
Ref 168: A small bowel follow-through may suggest the diagnosis of Crohn's Disease and is useful when the disease involves only the small intestine.
Ref 169: Because colonoscopy and gastroscopy allow direct visualization of only the terminal ileum and beginning of the duodenum, they cannot be used to evaluate the remainder of the small intestine.
A. Colonoscopy is a test that allows a Doctor to look at the inner lining of the large intestine - rectum and colon.
B. A thin, flexible tube called a colonoscope is used to look at the colon.
C. A Colonoscopy helps find ulcers, colon polyps, tumours and areas of inflammation or bleeding.
D. Endoscopy is a nonsurgical procedure used to examine a Person's digestive tract.
E. Using an Endoscope, a flexible tube with a light and camera attached to it, a Doctor can view pictures of the digestive tract on a colour TV monitor.
Ref 170: As a result, a barium follow-through X-ray, wherein barium sulfate suspension is ingested and fluoroscopic images of the bowel are taken over time, is useful for looking for inflammation and narrowing of the small bowel.
Ref 171: Barium Enemas, in which barium is inserted into the rectum and fluoroscopy is used to image the bowel, are rarely used in the work-up of Crohn's disease due to the advent of colonoscopy.
Ref 172: They remain useful for identifying anatomical abnormalities when strictures of the colon are too small for a colonoscope to pass through, or in the detection of colonic fistulae - in this case contrast should be performed with iodate substances.
Ref 173: Iodate From Wikipedia, the free encyclopedia.
A. The iodate anion, IO− 3 Space-filling model of the iodate anion
B. An iodate is a conjugate base of iodic acid.
C. In the iodate anion, iodine is bonded to three oxygen atoms and the molecular formula is IO− 3.
D. The molecular geometry of iodate is trigonal pyramidal.
E. Iodate can be obtained by reducing periodate with a thioether.
1. A thioether is a molecule with the group R-S-R.
2. The first atom in R is a carbon. Thioether take their name from ethers.
3. They have a sulphur instead of an oxygen atom between the two R.
4. Thioether's can have very bad smells like thiols.
5. They can also be called sulphides.
6. The C-S-C bond is at nearly 90 degrees.
7. Thioether's are important in biology.
8. They are present in some amino acids.
9. Petroleum has many thioether's in it as well.
10. Thioether's can be made in the laboratory by the reaction of a thiol with a base and an electrophile.
11. They can do many interesting reactions.
12. It is easy to oxidise them to sulfoxides and then sulfones.
F. The by product of the reaction is a sulfoxide.
G. Iodates are a class of chemical compounds - Examples are:
1. Sodium iodate - NaIO3.
2. Silver iodate - AgIO3.
3. Calcium iodate - Ca(IO3)2.
H. Iodates resemble chlorates with iodine instead of chlorine.
I. In acid conditions, iodic acid is formed.
J. Potassium hydrogen iodate (KH(IO3)2) is a double salt of potassium iodate and iodic acid and an acid as well.
K. Iodates are used in the iodine clock reaction.
L. Potassium iodate, like potassium iodide, has been issued as a prophylaxis against radio iodine absorption in some countries.
M. Potassium bromate and iodate: The presence of these chemicals in bread can harm a Human.
N. A recent study found cancer-causing chemicals in bread samples of virtually all top brands.
O. Nearly 84 percent of 38 commonly available brands of pre-packaged breads including pav and buns, tested positive for Potassium Bromate and Potassium Iodate, banned in many countries as they are listed as "hazardous" for public health, confirms the report by Centre for Science and Environment - CSE.
Ref 174: But what are these chemicals which are the cause of the panic.
A. According to CSE, Potassium Bromate (KBrO3) is a chemical which is classified as a category 2B carcinogen - something possibly carcinogenic to human beings.
B. Potassium iodate (KIO3) is a chemical which can contribute to thyroid-related diseases.
C. According to some reports, potassium bromate takes the form of white crystals or powder.
D. The CSE report further said - that Potassium Bromate is used as a flour treatment agent in bread and other bakery products; because it is a powerful oxidising agent which makes the bread fluffy, soft and gives it a good finish.
E. Under the perfect baking conditions, Potassium Bromate converts into Bromide, a harmless chemical.
F. But this does not happen in practice, some reports confirmed.
G. A 1982 research from Japan stated that it could also cause cancer in rats and mice.
H. Another study reported by a News outlet said; studies revealed that Potassium Bromate was a "genotoxic carcinogen," which is a chemical agent that damages genetic information and hence causes mutations.
I. The National Institute of Occupational Safety and Health (NIOSH) said that a Person may require medical attention if they are exposed to Potassium Bromate through the skin or eyes or if a Person ingests it.
Ref 175: CT and MRI scans are useful for evaluating the small bowel with enteroclysis protocols.
B. They are also useful for looking for intra-abdominal complications of Crohn's Disease, such as abscesses, small bowel obstructions, or fistulae.
C. Magnetic resonance imaging (MRI) is another option for imaging the small bowel as well as looking for complications, though it is more expensive and less readily available.
Conclusion... Items 172/3
A. Iodate; Of all the words I have researched as to the meaning of the word - and the above does not make it abundantly clear what iodate is actually used, this word has to perhaps be the most difficult of all words to establish a connection; with at least some Medical Science backing.
Ref 176: A complete blood count may reveal anaemia, which commonly is caused by blood loss leading to iron deficiency - a microcytic enemy or by vitamin B12 deficiency - a macrocytic enemy, usually caused by ileal disease impairing vitamin B12 absorption.
Ref 177: Rarely autoimmune Hemolysis may occur.
A. Hemolysis. At the end of their normal life span - about 120 days, Red Blood Cells are removed from the circulation.
B. Hemolysis involves premature destruction and hence a shortened RBC life span anything up to 120 days.
C. Anaemia results when bone marrow production can no longer compensate for the shortened RBC survival; this condition is termed Hemolytic Enemy.
D. If the marrow can compensate, the condition is termed Compensated Hemolytic Enemy.
E. Ferritin levels help assess - if iron deficiency is contributing to the enemy.
F. Erythrocyte sedimentation rate (ESR) and C-reactive protein help assess the degree of inflammation, which is important as ferritin can also be raised in inflammation.
G. Serum Iron, total iron binding capacity and transferrin saturation may be more easily interpreted in inflammation.
H. Enemy of chronic disease results in a Normocytic Enemy.
1. Normocytic Anemia's may be thought of as representing any of the following: a decreased production of normal-sized red blood cells. E.G., enemy of chronic disease, aplastic enemy; an increased destruction or loss of red blood cells. E.G., haemolysis, posthemorrhagic enemy; an uncompensated increase in plasma volume.
I. Other causes of anaemia include medication used in treatment of inflammatory bowel disease, like azathioprine, which can lead to cytopenia and sulfasalazine, which can also result in folate deficiency.
J. Testing for Saccharomyces Cerevisiae Antibodies (ASCA) and Anti neutrophil Cytoplasmic Antibodies (ANCA) has been evaluated to identify inflammatory diseases of the intestine and to differentiate Crohn's Disease from Ulcerative Colitis.
K. Furthermore, increasing amounts and levels of serological antibodies such as: ASCA, antilaminaribioside. ALCA, antichitobioside. ACCA, antimannobioside, antiLaminarin. anti-L and antichitin. anti-C - associate with disease behaviour and surgery and may aid in the prognosis of Crohn's Disease.
1. Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing." Is a medical term for predicting (Guessing) the likely outcome of a Patients current situation.
L. Low serum levels of vitamin D are associated with Crohn's Disease.
M. Further studies are required to determine the significance of this association.
Conclusion. I am unable to find any scientifically proven papers that confirm medical science knows anything of value when it comes to Blood - which contains some 2000-4000 chemicals that are changing, quicker than the speed of light thus in a constant state of untraceable flux.
Comparison of Crohn's Disease with Ulcerative Colitis.
Ref 178: The most common disease that mimics the symptoms of Crohn's Disease is Ulcerative Colitis, as both are inflammatory bowel diseases that can affect the colon with similar symptoms.
Ref 179: It is important to differentiate these diseases, since the course of the diseases and treatments may be different.
A. In some cases, however, it may not be possible to tell the difference, in which case the disease is Classified as Indeterminate Colitis.
Ref 180: Diagnostic findings: Crohn's Disease. Ulcerative Colitis. Terminal ileum involvement Colon involvement. Rectum involvement. Involvement around the anus. Bile duct involvement. No increase in rate of primary Sclerosing Cholangitis.
A. Sclerosing Cholangitis - is an uncommon condition affecting the bile ducts and liver.
1. Inflammation and scarring of the bile ducts can lead to liver damage and cirrhosis - a condition where normal liver tissue is replaced by scar tissue - fibrosis.
Ref 181: Higher rate of Distribution of disease Patchy areas of inflammation.
A. Continuous area of inflammation.
Ref 182: Endoscopy Deep geographic and vertiginous (snake-like) ulcers.
A. Continuous ulcer Depth of inflammation May be transmural, deep into tissues.
B. Shallow, mucosal Stenosis Common Seldom Granulomas on biopsy May have non-necrotizing non-peri-intestinal crypt granulomas.
C. Non-peri-intestinal crypt granulomas are as often - not seen.
Conclusion. Confirmation of that well know Scientific Medical dismissal of. "If the right one does not get you then the left one will."
Ref 183: Other conditions with similar symptoms as Crohn's Disease includes Intestinal Tuberculosis, Behçet’s Disease, Ulcerative Colitis, Nonsteroidal anti-inflammatory drug enteropathy, Irritable Bowel Syndrome and Celiac Disease.
A. Irritable Bowel Syndrome is excluded when there are inflammatory changes.
B. Celiac Disease cannot be excluded if specific antibodies - anti-transglutaminase antibodies are negative, nor in absence of intestinal villi atrophy.
Conclusion. Same as I said. How desperate does Medical Science have to get; to give one disorder two different names.
Management of Crohn's Disease.
Ref 184: Management Crohn's Disease and Ulcerative Colitis with medications is more or less than useful where it appears - Antibiotics are Effective in the long-term.
Ref 185: Generally not useful is Surgery as the condition often returns following removal of affected part usually deemed cured by removal of or parts of the colon.
Ref 186: There is no cure for Crohn's Disease and remission may not be possible or prolonged if achieved.
Ref 187: In cases where remission is possible, relapse can be prevented and symptoms controlled with medication, lifestyle, dietary changes, changes to eating habits - eating smaller amounts more often, reduction of stress, moderate activity and exercise.
Ref 188: Surgery is generally contraindicated and has not been shown to prevent remission.
Ref 189: Adequately controlled, Crohn's Disease may not significantly restrict daily living.
Ref 190: Treatment for Crohn's Disease is only when symptoms are active and involve first treating the acute problem, then maintaining remission.
Conclusion. As clear an indication as one could conspire to achieve or a demonstration of nothing of any value is known.
Ref 191: Certain lifestyle changes can reduce symptoms, including dietary adjustments, elemental diet, proper hydration and smoking cessation.
Ref 192: Diets that include higher levels of fiber and fruit are associated with reduced risk,
A. While diets rich in total fats, polyunsaturated fatty acids, meat and omega-6 fatty acids may increase the risk of Crohn's.
Ref 193: Smoking may increase Crohn's Disease; stopping is recommended.
Ref 194: Eating small meals frequently instead of big meals, may also help those with a low appetite to manage symptoms; with a balanced diet and proper portion control.
Ref 195: Fatigue can be helped with regular exercise, a healthy diet and enough quality sleep.
Ref 196: A food diary may help with identifying foods that trigger symptoms.
Ref 197: Some People should follow a low dietary fiber diet to control symptoms - especially if fibrous foods appears to cause symptoms.
Ref 198: Some People find relief in eliminating casein - protein found in cow's milk and gluten - protein found in wheat, rye and barley; from their diets.
Ref 199: They may have specific dietary intolerances - not allergies.
Ref 200: Acute treatments uses medications to treat any infection - normally antibiotics and to reduce inflammation - normally aminosalicylate anti-inflammatory drugs and corticosteroids.
A. When symptoms are in remission, treatment enters maintenance, with a goal of avoiding the recurrence of symptoms.
B. Prolonged use of corticosteroids has significant side-effects; as a result, they are, in general, not used for long-term treatment.
Ref 201: Alternatives include. Aminosalicylates alone, though only a minority of Patients are able to maintain the treatment and many require immunosuppressive drugs.
Ref 202: It has been also suggested that antibiotics change the Enteric Flora and their continuous use may pose the risk of overgrowth with pathogens such as Clostridium difficile.
A. Enteric Flora. The normal flora of the GI tract is composed of various bacteria and fungi that play a vital role in the digestion of food.
B. They also help restrict the growth of pathogenic organisms.
C. The use of broad spectrum antibiotics may change the balance of the normal flora, inhibiting the growth of normal flora and allowing bacteria resistant to the antibiotic to persist and overgrow.
D. Similarly, the use of anti-neoplastic drugs can lead to bacterial overgrowth that results in abdominal pain and diarrhoea.
Ref 203: Medications used to treat the symptoms of Crohn's Disease include - aminosalicylic acid (5-ASA) formulations, prednisone, immunomodulators such as azathioprine - given as the prodrug for 6-mercaptopurine, methotrexate, infliximab, adalimumab, certolizumab and natalizumab.
Ref 204: Hydrocortisone should be used in severe attacks of Crohn's Disease.
Ref 205: Biological Therapies are medications used to avoid long-term steroid use, decrease inflammation and treat people who have fistulas with abscesses.
A. Biological therapy is treatment designed to stimulate or restore the ability of the Body's immune - natural internal defense system to fight infection and disease.
B. Biological therapy is also called bio therapy or immunotherapy.
Ref 206: The gradual loss of blood from the gastrointestinal tract, as well as chronic inflammation, often leads to anaemia and professional guidelines suggest routinely monitoring for this.
Ref 207: Adequate disease control usually improves anaemia of chronic disease, but iron deficiency may require treatment with iron supplements.
A. Guidelines vary as to how iron should be administered.
B. Besides other, problems include a limitation in possible daily resorption and an increased growth of intestinal bacteria.
C. Some advise parenteral iron as first line as it works faster, has fewer gastrointestinal side effects and is unaffected by inflammation reducing enteral absorption.
D. Other guidelines advise oral iron as first line with Parenteral Iron reserved for those that fail to adequately respond as oral iron is considerably cheaper.
1. All agree that severe anaemia - haemoglobin under 10g/dL should be treated with parenteral iron.
E. Blood transfusion should be reserved for those who are cardiovascularly unstable, due to its relatively poor safety profile, lack of long term efficacy and cost.
Ref 208: Surgery Crohn's Disease - cannot be cured by surgery, as the disease eventually recurs, though it is used in the case of partial or full blockage of the intestine.
A. Surgery may also be required for complications such as obstructions, fistulas, or abscesses, or if the disease does not respond to drugs.
B. After the first surgery, Crohn's Disease usually comes back at the site where the diseased intestine was removed and the healthy ends were rejoined, however it can come back in other locations.
C. After a resection, scar tissue builds up, which can cause strictures, which form when the intestines become too small to allow excrement to pass through easily, which can lead to a blockage.
D. After the first resection, another resection may be necessary within five years.
E. For Patients with an obstruction due to a stricture, two options for treatment are considered - strictureplasty and resection of that portion of bowel.
F. There is no statistical significance between strictureplasty alone versus strictureplasty and resection in cases of duodenal involvement.
G. In these cases, re-operation rates were 31% and 27%, respectively, indicating that strictureplasty is a safe and effective treatment for selected People with duodenal involvement.
H. Postsurgical recurrence of Crohn's disease is relatively common.
I. Crohn's lesions are nearly always found at the site of the resected bowel.
J. The join - or anastomosis after surgery may be inspected, usually during a colonoscopy, and disease activity graded.
K. The "Rutgeert's score," is an endoscopic scoring system for post-operative disease recurrence in Crohn's Disease.
L. Mild postsurgical recurrences of Crohn's Disease are graded i1 and i2, moderate to severe recurrences are graded i3 and i4.
1. Fewer lesions result in a lower grade.
M. Based on the score, treatment plans can be designed to give the Patient the best chance of managing recurrence of the disease.
N. Short Bowel Syndrome (SBS, also Short Gut Syndrome or simply short gut, is caused by the surgical removal of part of the small intestine.
1. It usually develops in those Patients who have had half or more of their small intestines removed.
2. Diarrhoea is the main symptom, but others may include weight loss, cramping, bloating, and heartburn.
3. Short Bowel Syndrome is treated with changes in diet, intravenous feeding, vitamin- mineral supplements and treatment with medications.
4. In some cases of SBS, intestinal transplant surgery may be considered; though the number of transplant centres offering this procedure is quite small and it comes with a high risk due to the chance of infection and rejection of the transplanted intestine.
5. Bile acid diarrhoea is another complication following surgery for Crohn's Disease in which the terminal ileum has been removed.
1. This leads to the development of excessive watery diarrhoea.
2. It is usually thought to be due to an inability of the ileum to reabsorb bile acids after resection of the terminal ileum and was the first type of bile acid mal absorption recognized.
Conclusion. And of course the Mind being non Scientifically Proven does not exist.
We Human and indeed Animals - if we could only speak their dialect, cannot make changes to lifestyle and keep them if the Mind does not approve.
Ref 209: More than half of People with Crohn's Disease have tried complementary or alternative therapy.
Ref 210: These include diets, probiotics, fish oil and other herbal and nutritional supplements.
Ref 211: Some scientists have suggested more research into these is needed to discriminate between effective therapies and those that have not been found to be effective.
Ref 212: Acupuncture is used to treat Inflammatory Bowel Disease in China and is being used more frequently in Western society.
A. At this time, evidence is insufficient to recommend the use of Acupuncture.
Ref 213: Homeopathy is frequently used in Germany as a treatment for Crohn's Disease, though no clinical trials exist that demonstrate homeopathy is effective.
Ref 214: There are contradicting studies regarding the effect of Medical Cannabis on Inflammatory Bowel Disease.
A. And medical Science says this about Complimentary and Alternative therapy's with out a single cause known and not one cure to its name.
B. Surely it is time we all recognised if a Treatment does not cure or even manage very well - it does not deserve to be recognised with any label; let alone. Main Stream, Complimentary or alternative medicine.
Ref 215: Crohn's Disease is a chronic condition for which there is no cure.
A. It is characterised by periods of improvement followed by episodes when symptoms flare up.
B. With treatment, most People achieve a healthy weight and the mortality rate for the disease is relatively low.
C. It can vary from being benign to very severe and People with CD could experience just one episode or have continuous symptoms.
D. It usually reoccurs, although some People can remain disease free for years or decades.
E. Most People with Crohn's Disease live a normal life span.
F. However, Crohn's Disease is associated with a small increase in risk of small bowel and Colorectal carcinoma - bowel cancer.
Conclusion. The case for the prosecution rests My Lord.
Ref 216: Crohn's Disease is indicated if there is a Nutrient deficiency.
A. Ulcerative Colitis have a slight risk of Colon Cancer.
Ref 217: Considerable Prevalence exist of extra intestinal complications Iritis/uveitis for
A. Females 2.2% 3.2%.
B. Males 1.3% 0.9%
Ref 218: Primary Sclerosing Cholangitis for:
A. Females 0.3% 1%
B. Males 0.4% 3%
Ref 219: Ankylosing spondylitis for:
A. Females 0.7% 0.8%.
B. Males 2.7% 1.5%.
Ref 220: Pyoderma Gangrenosum for:
A. Females 1.2% 0.8%.
B. Males 1.3% 0.7%.
Ref 221: Erythema Nodosum for:
A. Females 1.9% 2%
B. Males 0.6% 0.7%
Ref 222: Complications of Crohn's Disease can lead to several mechanical complications within the intestines, including obstruction, fistulae and abscesses.
Ref 223: Obstruction typically occurs from strictures or adhesions that narrow the lumen, blocking the passage of the intestinal contents.
Ref 224: A fistulae can develop between two loops of bowel, between the bowel and bladder, between the bowel and vagina and between the bowel and skin.
Ref 225: Abscesses are walled off concentrations of infection, which can occur in the abdomen or in the perianal area.
Ref 226: Crohn's Disease is responsible for 10% of vesicoenteric fistulae and is the most common cause of ileovesical fistulae.
Ref 227: Endoscopic image of Colon Cancer identified in the sigmoid colon on screening colonoscopy for Crohn's Disease.
Ref 228: Crohn's Disease also increases the risk of Cancer in the area of inflammation.
A. For example, individuals with Crohn's Disease involving the small bowel are at higher risk for small intestinal cancer.
B. Similarly, People with Crohn's Colitis have a relative risk of 5.6 for developing Colon Cancer.
Ref 229: Screening for Colon Cancer with colonoscopy is recommended for anyone who has had Crohn's Colitis for at least eight years.
Ref 230: Some studies suggest there is a role for chemoprotection in the prevention of Colorectal Cancer in Crohn's Disease involving the colon; two agents have been suggested, folate and mesalamine preparations.
A. In the treatment of cancer, chemoprotective agents are drugs which protect healthy tissue from the toxic effects of anticancer drugs.
Ref 231: Individuals with Crohn's Disease are at risk of malnutrition for many reasons, including decreased food intake and malabsorption.
A. The risk increases following resection (Surgery) of the small bowel.
Ref 232: Such individuals may require oral supplements to increase their caloric intake, or in severe cases, total parenteral nutrition - TPN.
Ref 233: Most People with moderate or severe Crohn's Disease are referred to a dietitian for assistance in nutrition.
Ref 234: The major significant complications of Crohn's Disease include bowel obstruction, abscesses, free perforation and hemorrhage, which in rare cases may be fatal.
Ref 235: Crohn's Disease can be problematic during pregnancy and some medications can cause adverse outcomes for the Fetus or Mother.
Ref 236: Consultation with an obstetrician and gastroenterologist about Crohn's Disease and all medications facilitates preventative measures.
Ref 237: In some cases, remission occurs during pregnancy.
Ref 238: Certain medications can also lower sperm count or otherwise adversely affect a Man's fertility.
Conclusion. No one is questioning these symptoms cannot be scientifically seen - the question is; "why they occurred in the first instance and why the body's own immune systems do not automatically create a cure."
Ref 240: Epidemiology is the study and analysis of the patterns, causes and effects of health and disease conditions in defined populations.
A. It is the cornerstone of public health and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare.
Ref 240: The percentage of People with Crohn's Disease has been determined in Norway and the United States and is similar at 6 to 7.1:100,000.
Ref 241: The Crohn's and Colitis Foundation cites this number as approx. 149:100,000; others cite 28 to 199 per 100,000.
Ref 242: Crohn's Disease is more common in northern countries and with higher rates still in the northern areas of these countries.
Ref 243: The incidence of Crohn's Disease is thought to be similar in Europe but lower in Asia and Africa.
Ref 244: It also has a higher incidence in Ashkenazi Jews and smokers.
Ref 245: Crohn's Disease begins most commonly in People in their teens and 20s and People in their 50s through to their 70s.
Ref 246: It is rarely diagnosed in early Childhood.
Ref 247: It usually affects Female Children more severely than Males.
Ref 248: However, only slightly more Women than Men have Crohn's Disease.
Ref 249: Parents, Siblings or Children of People with Crohn's Disease are 3 to 20 times more likely to develop the disease.
Ref 250: Twin studies find that if one has the disease there is a 55% chance the other will too.
Ref 251: The incidence of Crohn's Disease is increasing in Europe.
Conclusion. An accountants dream or is it a nightmare.
Crohn's Disease Explored Explained Understood?
Finding the cause...
Ref 252: If we accept as truth the story of Adam - the first Man taking the Apple and Eve being the first Woman on Planet Earth, where still to day (2016) God has demonstrated very little tangible evidence he existed and even created the Earth; only to those who believe in God with passion and who dare or desires to argue with such an un provable viewpoint.
Ref 253: From this information - so many years later, where there are more People ill today than ever. It is reasonable to consider; Both Adam and Eve in their lives had some issues of Mind and Body and being on their own - sought to establish a manner these symptoms could be dealt with.
Ref 254: Since that time. Mankind through Medical Sciense has sought to understand the cause of illness through the ever skillful understandings of the Body - yet today of the approximately 100,000 illnesses recognised and diagnosed; not one has successfully had its true cause established.
Ref 255: During the now Thirty Four plus years I have specialised in treating People with multiple long-term symptoms of Mind and Body.
Ref 256: Not only have I never been able to update, thus improve on the above statement.
Ref 257: Following the treatment of any symptoms at the "cause," the relief always comes back to the same yet individual cause as being - a Process of the Mind via its intake and collective store of information and a perceptive value as how best to deal; via the entire Body Chemistry, the Brain as an organ of the Body with no thinking power and the Body; With the ultimate recipient of the now Toxic and Caustic Body Chemistry - that cannot be altered with any Management Techniques.
Crohn's Disease Explored Explained Understood?
Finding the cause...
Question. 2: This page contains a lot of research and presentation of the multitude of facts relating to these disorders - do you feel it is complete?
Answer. 2: No. It is clearly an ever-expanding protocol and it is clear for me will never-end; until the Mind is securely understood and accepted by ALL Humans and indeed their relationship with Animals - as the true cause of all illness.
A. However to answer your question with the available evidence there is S.I.B.O.
B. Small Intestinal Bacterial Overgrowth (SIBO), also termed bacterial overgrowths, or small bowel bacterial overgrowth syndrome - SBBOS.
C. Is a disorder of excessive bacterial growth in the small intestine.
D. Unlike the colon (or large bowel), which is rich with bacteria, the small bowel usually has fewer than 10,000 organisms per milliliter.
E. Patients with bacterial overgrowth typically develop symptoms including nausea, bloating, vomiting, diarrhea, malnutrition, weight loss and malabsorption, which is caused by a number of mechanisms.
F. The diagnosis of bacterial overgrowth is made by a number of techniques, with the gold standard being an aspirate from the jejunum; the part of the small intestine between the duodenum and ileum, that grows in excess of 105 bacteria per milliliter.
1. Aspiration means to draw in or out using a sucking motion.
2. It has two meanings: Breathing in a foreign object - sucking food into the airway.
3. A medical procedure that removes something from an area of the body.
4. These substances can be air, body fluids, or bone fragments.
5. An example is removing ascites - the accumulation of fluid in the peritoneal cavity, causing abdominal swelling, fluid from the belly area.
6. Aspiration as a medical procedure may also be used to remove tissue samples for a biopsy.
7. This is sometimes called a needle biopsy or aspirate.
8. For example, the aspiration of a breast lesion.
G. Risk factors for the development of bacterial overgrowth include dysmotility; anatomical disturbances in the bowel, including fistulae, diverticula and blind loops created after surgery and resection of the ileo-cecal valve; gastroenteritis-induced alterations to the small intestine; and the use of certain medications, including proton pump inhibitors.
H. Small bowel bacterial overgrowth syndrome is treated with an elemental diet or antibiotics, which may be given in a cyclic fashion to prevent tolerance to the antibiotics, sometimes followed by prokinetic drugs to prevent recurrence if dysmotility is a suspected cause.
Question. 3: Is the suggestion I.B.S and S.I.B.O are one and the same - true?
Answer. 3: Taking into consideration the bulk of this web page is from the medical profession themselves it is most reasonable to accept - there is not one word that truly explains the cause of any of the related disorders herby contained, thus the answer within the medical profession is. No one Knows the answer to this interesting question or perhaps better said; Does not desire to know.
Question. 4: And your answer?
Answer. 4: All symptoms of the entire Body are to be seen like the fruit on a tree - all came from the same seed.
A. Thus from the Emotional Phenotype are an expression of the entire Body Chemistry as instructed by the Mind, which can only be altered by the Mind itself - never by mechanical means.
Question. 5: Where does that leave us to explore now?
Answer. 5: Many times I read well meaning People: either Therapists or even People that have the disorder with the belief. "If you have never had the disorder then you cannot possibly understand and If the best Doctors in the world cannot cure then - my way or no way is the only way, often as a sales technique.
Question. 6: Should one not be careful with the last few words above. Knowing how you talk about the findings of the Medical Profession.
Answer. 6: Good observation and you are correct.
1. When I work with a Person it is always. Their Truth is most important; thus they must take ultimate responsibility of the eventual cure as they have done the work - I only showed them how.
2. Having accepted and worked initially with my techniques - the Person automatically as a learning of life, incorporates this learning as time passes; into their daily activity as their own.
3. If one looks critically at my web site - apart for one line. "The only thing you have to lose is the Pain," you will not see any form of Selling Talking Cures, nor advertising of products- books. Etc. Etc. Etc.
4. The reason for this is as above states. People have to desire deep in their Mind they wish to purchase and work with the protocols of Talking Cures; Mind is the creator of all illness. Thus the treatment is never a management tool moreover for them alone - not ONLY my financial reward.
Question. 7: May we explore such a published proclamation from an online therapist and sufferer combined?
Answer. 7: Yes of course. This is a copy (grammatically) edited by myself (dare I do such a thing) to make it into a readable questions/answers format. Let us accept the heading went something like...
"...Are you a Woman Suffering From Abdominal Pain."
A. And continued with. "Do any of these sound familiar to you:"
1. Painful bloating. 2. Irregular bowel movements. 3. Constipation. 4. Diarrhea, or all these.
5. Excessive gas. 6. Fatigue. 7. Acid Reflux. 8. Abdominal Cramping.
B. In other words, does your overall digestion generally just give you grief.
C. If you do - many, these types of symptoms result in a diagnosis of; Irritable Bowel Syndrome - I.B.S.
D. Finding and Understanding the Cure.
E. Finding and living with the Understanding.
Ref 258: It is that time of year again… summer travel!
Ref 259: The thing I (the online therapist) hear over and over again is this. “Well, I’m ready to start eating healthy, but first I’ve got this vacation.”
A. There are so many things wrong with this statement and let me tell you why.
B. These changes are meant to be permanent lifestyle changes, not a temporary fix.
C. I see People time and time again work so hard at improving laboratory numbers on a sheet of paper.
D. Only to let the gains slip back once the mark their Doctor was looking for - has been achieved.
E. Do not let that be you!
F. Take steps, even if small tiny ones, to improve your diet for the long haul.
G. Ditch the fast food.
H. If traveling by road, stop at grocery stores instead of fast food.
I. For the same price as a fast food meal for four, you can easily buy a loaf of bread, delicatessen meat, condiments, etc and make your own sandwiches.
J. Or you can buy them at the store’s delicatessen Counter.
K. Whatever you do, say no to fast food.
L. Pack snacks!
M. As much as possible, bring your own healthy snacks on trips.
N. Personally I like to pack baggies with dried fruit and nuts.
O. That keeps me away from sugary things found in convenient stores and again, saves time.
P. In my opinion that means more time at the beach and less time searching for food.
Q. Hit the gym!
R. Or at the very least, plan in some exercise during your trip.
S. Again, this is not a vacation from healthy habits.
T. If you are a runner, plan a morning run through the city or along the beach.
U. If you like the gym, maybe there is a workout room in the hotel.
V. Or if walking is your thing, get out there and spend the day sight seeing.
W. Keeping up the movement will help when those little splurges do come along.
X. Speaking of splurges, think 80/20 rule.
1. Basically, eat healthy 80% of the time and allow for some fun foods 20% of the time.
Y. This gives you some freedom for, say, an ice cream on the boardwalk, or a dessert after dinner, but still reminds you to stick to healthy eating most of the time.
Z. Along with continuing the exercise, you will be far less likely to gain weight while out having fun.
Ref 260: What is IBS?
A. It is a condition affecting the large intestine, causing many of the symptoms previously listed.
B. In many cases it acts as a catch-all diagnosis when other more definable problems, like Crohn’s or Ulcerative Colitis, have been ruled out.
C. IBS often does not produce any damage to the intestines but certainly causes a host of unpleasant symptoms.
D. Treatment is usually dietary modification and sometimes medications to ease the discomfort.
E. What we are now learning about I.B.S, however, is that there are a large portion of folks for which the large intestine is actually not the sole player.
F. For some, it is actually the Small Intestine (SI) where the action is happening.
G. In fact, researchers have uncovered a condition by which bacterial imbalances occurs in the SI, setting the stage for a whole host of symptoms that look just like I.B.S.
Ref 261: They call this condition Small Intestinal Bacterial Overgrowth (SIBO).
A. So what if… just what if, a large number of these “I.B.S” People do not actually have I.B.S.
B. What if it is SIBO?
C. Well, that is exactly what is being reported.
D. Currently it is estimated that about 20% of People have I.B.S, and about 60% of those are actually caused by S.I.B.O.
E. That is certainly something to stop and think about.
F. For many I.B.S sufferers, we are focusing on the wrong treatments.
G. So what exactly is; S.I.B.O and how do we treat it?
H. Let us talk a bit about normal digestion first so we can set the stage for what goes wrong in S.I.B.O.
I. Bear with me for this exciting trip down the digestive tract.
1. When we chew and swallow, there is an arsenal of acid in our stomach at the ready to start breaking down certain amino acids and killing unwanted bacteria that we consume.
2. As food continues its journey through the system, it hits the small intestine (SI) where the acid is neutralized and digestive enzymes move in to start breaking down our meal, enabling the absorption of nutrients.
3. Whatever is leftover, mainly fiber and other undigested material, is pushed into the colon and prepared for excretion.
4. Although I have simplified this system greatly, it is a pretty amazing process.
5. Guiding food through the system is a process call peristalsis.
6. We have peristalsis in the colon, pushing stools to the colon for excretion and we also have peristalsis in the small intestine, pushing food contents through to allow for nutrient absorption and the rest for eventual excretion.
7. In the SI, one important peristaltic motion is coordinated by what we call the Migrating Motor Complex, or the MMC.
8. The MMC, in the fasting state. ie 90 -120min after we eat, initiates a cleansing wave that helps push contents through and out of the SI.
9. It also pushes unwanted bacteria out the door.
10. Also, between each part of the digestive tract we have valves that help keep food where it should be and, ideally, moving in a downward fashion.
11. Between the esophagus and the stomach we have the esophageal sphincter and between the SI and large intestine we have the ileocecal valve.
12. Both are intended to prevent back-flow from the previous organ.
13. When all aforementioned parts work as designed, we have healthy digestion.
14. At any point in this delicate system, however, we can have malfunctions, then setting the stage for unwanted bacteria to take hold in the SI.
15. First, a Person may lack adequate Stomach Acid.
16. While this alone is usually not enough to cause S.I.B.O, it certainly can contribute, especially when combined with other malfunctions.
Ref 262: How many People are on Proton Pump Inhibitors?
A. Proton Pump Inhibitors (PPIs)? PPIs are a group - class of medicines that work on the cells that line the stomach, reducing the production of acid.
B. They include esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole, and have various other brand names.
Ref 253: Or may have H Pylori.
A. H. pylori are spiral-shaped bacteria that grow in the digestive tract and have a tendency to attack the stomach lining.
Ref 254: Low stomach acid equals impaired digestion and an increase in bacteria reaching the SI.
Ref 255: Also, there can be a breakdown in the function of the MMC, inhibiting the cleansing wave that is supposed to take that unwanted bacteria out and away.
A. This is a definite contributor to S.I.B.O.
Ref 256: What can cause a breakdown in the Migrating Motor Complex - MMC.
A. Well, food poisoning for one.
B. Food poisoning produces a toxin that damages the nerves of the SI, inhibiting the action of the MMC.
C. Instead of pushing those critters out, they are allowed to stay and they set up shop.
D. Getting them out can be a monumental task.
Ref 257: Another impairment leading to S.I.B.O is dysfunction with the ileocecal valve.
A. If that valve is faulty and allows back-flow from the large intestine, bacteria can get into the SI which normally should not be there.
B. This again sets the stage for S.I.B.O to develop.
Ref 258: Other potential causes can be structural abnormalities in the SI - that decrease the movement of contents, as well as adhesions that allow bacteria to find a foothold and stake a claim in the land of the SI.
Ref 259: Such a complicated mess, is it not.
Ref 260: How does one know if they have S.I.B.O.
A. Well, I (the therapist) find that new onset of persistent gas and severe bloating is one clue.
B. It certainly is not diagnostic, but it definitely perks my ears.
Ref 261: Diet often affects this and Patients will note that certain foods make the condition better or worse.
Ref 262: Other hints are the I.B.S - like symptoms that we described earlier.
Ref 263: Additionally there may be a host of vague symptoms that were initially attributed to other causes.
A. These include reflux/GERD, fatigue, joint pain, headaches/migraines, brain fog and weight changes, among others.
B. Some of these are likely due to food sensitivity reactions brought on by the S.I.B.O.
C. Bacteria in the SI increases the risk for leaky gut, so often food sensitivities and SIBO go hand in hand.
D. There can also be malabsorption due to the bacteria damaging the brush border of the SI where our enzymes are produced.
E. Less digestive enzymes equals less absorption of nutrients.
F. Seriously, what a gigantic mess.
G. So what do we do?
Ref 264: Well, a good first step is getting tested.
A. Yes, there are tests to see if you have these buggers in your system, thank goodness.
B. If you do, there are specific prescription and herbal protocols that can be utilized.
C. These options can be discussed with a knowledgeable MD or ND that can recommend the right course of action.
Ref 265: Diet interventions can also be extremely helpful and are a key part of the process.
A. The thing is, those unwanted bacteria in the SI like to ferment specific carbohydrate substrates, so diets like FODMAPs, the Specific Carbohydrate Diet, GAPs and others can be useful.
Ref 266: I (online therapist) specialise in using these diets with clients as a key part of S.I.B.O management.
Ref 267: Clearly, S.I.B.O is a critical consideration in cases of digestive complaints, especially those with I.B.S.
Ref 268: In fact many I.B.S diagnoses are actually S.I.B.O in disguise as the symptoms between the two often overlap.
Ref 269: Hopefully S.I.B.O knowledge will continue to spread, allowing millions of People to get the appropriate treatment for a condition that is treatable but unfortunately not yet mainstream in the gastrointestinal community.
A. Not sure if your digestive issue might be S.I.B.O.
B. I would love to review your health history with you and see what we can uncover.
C. I (Online therapist) have a great group of Doctors and Specialists I refer to if testing and treatment looks like a good course of action and of course we can discuss dietary protocols that can often get you feeling at least a little better within a week or less.
D. Do not let these issues fester and only worsen over time.
E. Call Us.
Ref 270: There is research to support I.B.S, being caused by an as-yet undiscovered active infection.
Ref 271: Other researchers have focused on an unrecognized protozoal infection as a cause of I.B.S as certain protozoal infections occur more frequently in I.B.S Patients.
A. Two of the Protozoa investigated have a high prevalence in industrialized countries and infect the bowel, but little is known about them as they are recently emerged pathogens.
B. Protozoa In some historical systems of biological classification, protozoa were defined as single-celled organisms with animal-like Behaviours.
1. The group was regarded as the zoological counterpart to the "protophyta," which were considered to be plant-like, as they are capable of photosynthesis.
2. The term Protozoa was introduced in 1818 for a taxonomic class.
3. The use of Protozoa as a formal taxon has been discouraged by some researchers, mainly because the term, which is formed from the Greek protos "first" + zoia, plural of zoion, "animal," misleadingly implies kinship with animals (metazoa) and promotes an arbitrary separation of "animal-like" from "plant-like" organisms.
4. Modern ultra structural, biochemical and genetic techniques have shown; that protozoa, as traditionally defined, belong to widely divergent lineages and can no longer be regarded as "primitive animals."
Complementary and Alternative Medicine.
Ref 272: Crohn’s Disease is a chronic condition for which there is currently no cure.
Ref 273: It is characterized by periods of improvement followed by episodes when symptoms flare up.
Ref 274: With treatment, most People achieve a healthy height and weight and the mortality rate for the disease is relatively low.
Ref 275: However, Crohn’s Disease is associated with an increased risk of small bowel and colorectal carcinoma, including bowel cancer.
Ref 276: Researchers at University College London have questioned the wisdom of suppressing the immune system in Crohn’s Disease, as the problem may be an underactive rather than an overactive immune system:
Ref 277: Their study found that Crohn’s Disease Patients showed an abnormally low response to an introduced infection, marked by a poor flow of blood to the wound.
Ref 278: Since Crohn’s Disease is an auto-immune disease it is thought that the Body is attacking itself and thus cannot fight off infection or wounds because it is busy mistakenly fighting itself.
Completion of the contribution of the online therapist and sufferer.
A. Item 276, perfectly explains - It can be or should be seen the therapist is trying desperately to hide how little is known whist at the same time creating an aura of scientific knowledge, including - protecting the Pay on the way out please, regimen.
B. Surly if one is to adopt this approach - and there is no suggestion they should not, People all over the world require assistance and treatment of their Mind and Body concerns and item 278 with the use of the word "thought" confirms this form of assistance can surely only be short lived and the long term outcome no better than perhaps doing nothing at all.
Ref 279: Hirschsprung's Disease or Hirschsprung Disease - HD.
A. Also called Congenital Megacolon or Congenital Aganglionic Megacolon, is a form of megacolon that occurs when part or all of the large intestine or antecedent parts of the gastrointestinal tract have no ganglion cells and therefore cannot function.
B. During normal prenatal development, cells from the neural crest migrate into the large intestine - colon to form the networks of nerves called the myenteric plexus - Auerbach plexus situated between the smooth muscle layers of the gastrointestinal tract wall and the submucosal plexus - Meissner plexus, within the submucosa of the gastrointestinal tract wall.
1. Myenteric Plexus. is the major nerve supply to the gastrointestinal tract and controls GI tract motility.
2. Auerbach Plexus. The myenteric plexus or Auerbach's plexus provides motor innervation to both layers of the muscular layer of the gut
3. Submucosa. Is the layer of dense irregular connective tissue that supports the mucosa - mucous membrane and joins it to the muscular layer, the bulk of overlying smooth muscle fibers running circularly within layer of longitudinal muscle.
C. In Hirschsprung's Disease, the migration is not complete and part of the colon lacks these nerve bodies that regulate the activity of the colon.
Ref 280: The affected segment of the colon cannot relax and pass stools through the colon, creating an obstruction.
Ref 281: In most affected People, the disorder affects the part of the colon that is nearest the anus.
Ref 282: In rare cases, the lack of nerve bodies involves more of the colon.
Ref 283: In five percent of cases, the entire colon is affected. Stomach and esophagus may be affected too.
Ref 284: Hirschsprung's Disease occurs in about one in 5,000 of live births.
Ref 285: It is usually diagnosed in Children and affects Boys more often than Girls.
Ref 286: About 10% of cases are familial.
A. familial. A condition that tends to occur more often in family members than is expected by chance alone. A familial disease may be genetic.
Conclusion. The entire section here is far to clever for the writers own good; thus sums up to "we do not know."
Signs and symptoms.
Ref 287: Typically, Hirschsprung's Disease is diagnosed shortly after birth, although it may develop well into adulthood, because of the presence of megacolon, or because the Baby fails to pass the first stool - meconium within 48 hours of delivery.
A. Megacolon, is an abnormal dilation of the colon - also called the large intestine.
1. The dilation is often accompanied by a paralysis of the peristaltic movements of the bowel.
B. Meconium. Is the earliest stool of a mammalian infant.
1. Unlike later feces, meconium is composed of materials ingested during the time the infant spends in the uterus: intestinal epithelial cells, lanugo, mucus, amniotic fluid, bile, and water.
Ref 288: Normally, 90% of Babies pass their first meconium within 24 hours and 99% within 48 hours.
Ref 289: Other symptoms include green or brown vomit, explosive stools after a doctor inserts a finger into the rectum, swelling of the abdomen, lots of gas and bloody diarrhea.
Ref 290: Some cases are diagnosed later into Childhood, but usually before age 10.
Ref 291:The Child may experience fecal retention, constipation, or abdominal distention.
Ref 292: With an incidence of one in 5,000 births, the most cited feature is absence of ganglion cells: notably in Males, 75 percent have none in the end of the colon - recto-sigmoid and eight percent lack ganglion cells in the entire colon.
1. Recto-sigmoid. The rectosigmoid junction is between the sigmoid colon and rectum and 15 to 17 cm from the anal verge.
2. The rectum is approximately 12 cm long and 4 to 16 cm from the anal verge
Ref 293: The enlarged section of the bowel is found Proximally, while the narrowed, Aganglionic section is found Distally, closer to the end of the bowel.
1. Proximally. Something that is proximal - is situated closest to the point of attachment or origin.
A. In medicine, it means closest to the center of the body.
2. Aganglionic. Is a form of megacolon that occurs when part or all of the large intestine or antecedent parts of the gastrointestinal tract have no ganglion cells and therefore cannot function.
3. Distally. Situated away from the center of the Body, or from the point of origin; specifically applied to the extremity or distant part of a limb or organ.
Ref 294: The absence of ganglion cells results in a persistent over-stimulation of nerves in the affected region, resulting in contraction.
Ref 295: In some extremely rare cases, the absence of ganglion cells continues to spread after the corrective surgery, resulting in multiple surgeries.
Ref 296: Those Patients that also have thyroid cancer - may be able to digest food properly, but may not be able to use the nutrients properly.
A. If medical science were to stand back and observe the true long-term successes of the outcome of their efforts, they would see they are the only business never once to have improved its product outcome.
B. From this revelation they would surely start the insidious process of understanding the Mind and how it interrelates and interacts with the body via the brain and the entire body chemistry.
C. Then this section would surely be where it belongs - somewhere near the beginning of this paper, instead of at the end, as though it were an afterthought.
Ref 297: The most accepted theory (guesswork) of the cause of Hirschsprung Disease is that there is a defect in the Craniocaheir efforts and see they amount oudal Migration of Neuroblasts originating from the neural crest that occurs during the first 12 weeks of Gestation.
1. Pathophysiology. Pathophysiology or physiopathology is a convergence of pathology with physiology.
A. Pathology is the medical discipline that describes conditions typically observed during a disease state.
B. Physiology. Is the biological discipline that describes processes or mechanisms operating within an organism.
2. Craniocaudal. Is an - Anatomical Term of Location. IE: description of a direction and means directed; "from head to feet."
3. Neuroblasts. An embryonic cell from which a nerve cell develops.
A. Neuroblasts are a model system to study self-renewal and differentiation.
4. Gestation. The process or period of developing inside the womb between conception and birth.
Ref 298: Defects in the differentiation of neuroblasts into ganglion cells and accelerated ganglion cell destruction within the intestine may also contribute to the disorder.
Ref 299: This lack of ganglion cells in the myenteric and submucosal plexus is well-documented in Hirschsprung's Disease.
Ref 300: With Hirschsprung's Disease, the segment lacking neurons - aganglionic, becomes constricted, causing the normal, proximal section of bowel to become distended with feces.
Ref 301: This narrowing of the distal colon and the failure of relaxation in the aganglionic segment are thought (guessed) to be caused by the lack of neurons containing nitric oxide synthase.
1. Nitric Oxide Synthase. Nitric oxide synthases (EC 220.127.116.11) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.
A. Nitric Oxide is an important cellular signaling molecule.
B. It helps modulate vascular tone, insulin secretion, airway tone and peristalsis - is also involved in angiogenesis and neural development.
2. Angiogenesis. the growth of new capillary blood vessels in the Body.
A. For example, cancerous tumors release angiogenic growth factor proteins.
3. Neural Development refers to the processes that generate, shape and reshape the nervous system, from the earliest stages of embryogenesis to the final years of life.
A. The study of neural development aims to describe the cellular basis of brain development and to address the underlying mechanisms.
4. Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in Humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7.
Ref 302: The equivalent disease in horses is Lethal white syndrome.
Ref 303: Genetic basis Several genes and specific regions on chromosomes (loci) have been shown or suggested (guessed) to be associated with Hirschsprung's Disease.
Ref 304: Hirschsprung's Disease can also present as part of a multisystem disorder, such as Down syndrome, Bardet-Biedl syndrome, Waardenburg-Shah syndrome, Mowat-Wilson syndrome, Goldberg-Shprintzen megacolon syndrome, cartilage-hair hypoplasia, multiple endocrine neoplasia type 2, Smith-Lemli-Opitz syndrome and congenital central hypoventilation syndrome.
1. Multisystem Disorder. The concept of multisystem disorders is not new, however the meaning of “multisystem” as used in the literature is largely implicit and rarely defined explicitly.
Ref 305: The RET proto-oncogene accounts for the highest proportion of both familial and sporadic cases, with a wide range of mutations scattered along its entire coding region.
1. A Proto-Oncogene is a gene that can cause cancer if it is mutated or over-expressed.
Ref 306: Research published in 2002 suggested that Hirschsprung's Disease may be caused by the interaction between two proteins encoded by two variant genes.
Ref 307: The RET proto-oncogene on chromosome 10 was identified as one of the two genes involved.
Ref 308: The other protein that RET must interact with in order to cause Hirschsprung’s Disease is termed EDNRB and is encoded by the gene EDNRB located on chromosome 13.
Ref 309: Hirschsprung's Disease, Hypoganglionosis, Gut Dysmotility, Gut Transit Disorders and Intussusception have been recorded with the Dominantly Inherited Neurovisceral Porphyrias - acute Intermittent Porphyria, Hereditary Coproporphyria, Variegate Porphyria.
1. Hypoganglionosis has been associated with fewer intestinal ganglion cells.
A. However, current reports questioned the validity of this clinical entity.
B. The aim of recent studies is to demonstrate the existence of hypoganglionosis.
2. Gut Dysmotility. Is a condition in which muscles of the digestive system become impaired and changes in the speed, strength or coordination in the digestive organs occurs.
A. In the normal small intestine, liquefied food and secretions including digestive enzymes are pushed onwards by waves of muscular contraction.
3. Gut Transit Disorders. The phrase intestinal motility disorders applies to abnormal intestinal contractions, such as spasms and intestinal paralysis.
A. In a broad sense, any alteration in the transit of foods and secretions into the digestive tract may be considered an intestinal motility disorder.
4. Intussusception. Is a medical condition in which a part of the intestine invaginates - folds into another section of intestine, similar to the way the parts of a collapsible telescope retract into one another. This can often result in an obstruction.
5. Neurovisceral Referring to the innervation of the internal organs by the autonomic (visceral motor) nervous system.
A. Current research suggests - the outlines of a model that integrates autonomic, attentional and affective systems into a functional and structural network, may help to guide the understanding of Emotion Regulation and Dysregulation.
B. In addition hope to emphasize the relationship between Attentional Regulation and affective processes and propose a group of underlying physiological systems that serve to integrate these functions in the service of self-regulation and adaptability of the organism.
C. Further attempts will be to place this network in the context of dynamical systems models which involve feedback and feed forward circuits with special attention to negative feedback mechanisms, inhibitory processes and their role in response selection.
D. From a systems perspective, inhibitory processes can be viewed as negative feedback circuits that allow for the interruption of ongoing behavior and the re-deployment of resources to other tasks.
E. When these negative feedback mechanisms are compromised, positive feedback loops may develop as a result - of dis-inhibition.
F. From this perspective, the relative sympathetic activation seen in anxiety disorders may represent dis-inhibition due to faulty inhibitory mechanisms.
6. Porphyrias. Porphyria. a rare hereditary disease in which there is abnormal metabolism of the blood pigment haemoglobin. Porphyrins are excreted in the urine, which becomes dark; other symptoms include mental disturbances and extreme sensitivity of the skin to light.
7. Hereditary. A descriptive term for conditions capable of being transmitted from Parent to offspring through the genes.
A. The term Hereditary is applied to diseases such as hemophilia and characteristics - such as the tendency toward baldness that pass from Parents to Children.
8. Coproporphyria. (HCP) is a disorder of heme biosynthesis, classified as an acute hepatic porphyria.
A. Hepatic Porphyrias is a form of porphyria in which the enzyme deficiency occurs in the liver.
1. HCP Hereditary Coproporphyria - HCP is a disorder of heme biosynthesis, classified as an acute hepatic porphyria. is caused by a deficiency of the enzyme coproporphyrinogen oxidase, coded for by the CPOX gene and is inherited in an autosomal dominant fashion, although homozygous individuals have been identified.
2. Alternative forms of a given gene are called alleles and they can be dominant or recessive.
3. When an individual has two of the same allele, whether dominant or recessive, they are homozygous. Heterozygous means having one each of two different alleles.
4. Unlike acute intermittent porphyria, individuals with HCP can present with cutaneous findings similar to those found in porphyria cutanea tarda in addition to the acute attacks of abdominal pain, vomiting and neurological dysfunction characteristic of acute porphyrias.
5. Like other Porphyrias, attacks of HCP can be induced by certain drugs, environmental stressors or diet changes.
A. The exact incidence of HCP is difficult to determine, (guess) due to its reduced penetrance.
6. Variegate Porphyria. Is caused by mutations in the PPOX gene.
A. Mutations in the PPOX gene reduce the activity of protoporphyrinogen oxidase, allowing compounds called porphyrin precursors to build up in the Body.
B. These compounds are formed during the normal process of heme production, but reduced activity of Protoporphyrinogen Oxidase allows them to accumulate to toxic levels.
1. Protoporphyrinogen oxidase is responsible for the seventh step in biosynthesis of protoporphyrin IX.
2. This porphyrin is the precursor to hemoglobin, the oxygen carrier in animals and chlorophyll, the dye in plants.
3. The enzyme catalyzes the dehydrogenation - removal of hydrogen atoms of protoporphyrinogen IX - the product of the sixth step in the production of heme to form protoporphyrin IX.
4. One additional enzyme must modify protoporphyrin IX before it becomes heme.
5. Inhibition of this enzyme is a strategy used in certain herbicides.
C. Heme synthesis occurs partly in the mitochondria and partly in the cytoplasm.
D. The process begins in the mitochondria because one of the precursors is found only there.
E. Since this reaction is regulated in part by the concentration of heme, the final step (which produces the heme) is also mitochondrial.
F. Many of the intermediate steps are cytoplasmic.
G. It has been noticed in the pathway there is a branch with no apparent useful end product.
H. More than 130 mutations in the PPOX gene have been identified in People with variegate porphyria.
I. A particular PPOX gene mutation is found in about 95 percent of families with the disorder from one studied country.
J. Nongenetic factors such as certain drugs, alcohol, dieting, as well as other genetic factors that have not been identified, also contribute to the characteristic features of variegate porphyria.
Ref 310: Biochemical and molecular testing can be used to narrow down the diagnosis of a porphyria and identify the specific genetic defect.
Ref 311: Overall, porphyrias are rare diseases.
Ref 312: The combined incidence for all forms of the disease has been estimated at 1:20,000.
Ref 313: Children may require enzyme or DNA testing for these disorders as they may not produce or excrete porphyrins prepuberty.
A. Of course as much as we have to recognise the necessity and importance of understanding this illness in Children from birth until their untimely and perhaps painful death, is it not more important to understand item 297 and the implication contained within the last part. "Craniocaheir efforts and see they amount oudal Migration of Neuroblasts originating from the neural crest that occurs during the first 12 weeks of Gestation."
B. For if does not understand the implications herewith then one cannot ever makes sense of this complex not complicated disorder and the lifetime of ever changing symptoms of Mind and Body a Person could or would experience."
I am given to understand Sciense seeks to answer simple questions...
...sadly I can find no tangible evidence of this and if we take just this paper one simple request of a question jumps out time and time again...
"...The cause is not known and there is no known cure..."
Yet never once do I hear this question asked...
"...Why we say - that we do not know; but we are now asking "why".
The truth hurts and so it should that is why it is the truth - mistruths never truly show the damage caused.
Question. 8. Do you have a view of the many forms of treatments for this complex disorder including Alternative/Complimentary Medicines that are available?
Answer. 8. It is clear on reading this collection of information - a lot of self-management is involved, this appears to be because, nothing is known about or researched as to the real cause of any illness and how to resolve the real cause, let alone Crohn's Disease and other associated intestine-bowel disorders.
A. Moreover; it also appears none of the treatments available today are of long-term duration in their ability to control the symptoms.
B. May we accept therefore every Person with a treatment modality is doing their very best to alleviate the suffering of the millions of People with the disorder and that includes - Medical Science; whether it likes it or not.
C. With all forms of Alternative and or Complimentary treatments - let us not forget; none of them would be required, if allopathic medicine actually said what is supposed to happen with Scientifically Proven treatments. The ailment is cured or even well managed long-term.
D. Thus we can consider yes. Alternative and Complimentary methods of treatment are in many ways affective and like any of the allopathic treatments mentioned in this document, have a part to play until Medical Science for the very first time in history accepts the Mind is the creator of all illnesses and sets about giving some form of Scientific Validation to this much maligned by the medical profession themselves - way of observing illness, instead the aged modality recognised in the factious story of. Dr Jekyll & Mr Hyde
E. If we are to consider the viewpoint of the Mind is the creator of all illness, based on - if the Mind does not remember illness, then then can be no illness as the immune systems would have automatically created the necessary repair.
1. From which point the Mind has no requirement to remember the originating Pain - whether it is Emotional or Physical.
F. However it is imperative to consider - within this Twenty First century understanding of illness.
1. As the Mind is the creator of all intestinal disorders; quicker than the speed of light, it will, before any medication has fully entered the system or any alternative/complimentary treatment starts to be effective, move from sub-clinical to diagnosable - having created a new and more mysterious aspect to this already mysterious; as to its true cause and still, in 2017; has no disease modifying cure.
Question. 9. Within your answer to question Answer 8 C: is it fair to say what you are saying is the days of laughing at New and Innovative Understandings regarding how illness is caused and sustained by the Body has had its day and only today exposes the Person or Institutional Body for their thousands of years of failure to long-term improve a Person health and well being?
Answer. 9. Sadly yes - any Person or Institutional Medical Body today that makes any form of criticism relating to any illness or makes the suggestion to an innovator; "You are being very controversial," is clearly demonstrating the long-held desire of superiority by attempting to gather strength in numbers to hide the fact - no one ever becomes truly well from any treatments - and that sometimes includes Talking Cures.
Question. 10. Why are you being derogatory to Talking Cures?
Answer. 10. I am not - I am being truthful; working on the secure understanding, if one cannot accept harsh criticism of the modality one doth profess, is there not something wrong with not only oneself but the very modality I demand so much personal and therapeutic trust from.
A. Moreover it is the truth; so often the more successful Talking Cures is - the more not only the ill Person, but also all of the People surrounding them; will seek to ensure the Protective wall illness appears to offer - is never removed.
Question 11. Are you suggesting it is possible even for Talking Cures to fail?
Answer. 11. Sadly yes. However - although this sounds rather like a self-protection - I can say If Talking Cures takes on a Person with Multiple long-term symptoms with no set asides...
A. By - Explaining to the Patient on the first appointment." We do not know what we can do with those symptoms but let that not stop us working towards a resolution of the presenting symptoms."
Any subsequent lack of success will prevail if:
B. I had not sustained the feeling within the Patient and myself - this is what we are working towards - but make no promises, only fools do that.
C. The Person's history is too Painful for them to revisit and resolve.
D. All Family members and friends and often including medical practitioners deem - because they see change in their loved one, they do not or will not recognise or accept as the Person they knew, loved or who they used to be - will become extremely destructive of Talking Cures and their loved one undergoing treatment - as they know they are losing control of them.
E. This includes the Person themselves as the closer they get to achieving well-health of Mind and Body the harder the subconscious Mind will instruct them to dismiss Talking Cures as not being liked or trusted anymore - in order to ensure the Protective wall of illness is sustained...
...thereby protecting the Person and creators of all illness from the true cause of the illness.
Conclusion. Question 11: In my now Thirty Four plus year career, far too many times have I been made aware of significant Person in an ill Person's life saying to me after hearing...
"...Based on the information you provide I feel sure your loved one can be helped..."
they reply with...
"...No we have done enough to find a cure we are not going to do any more."
Question. 12. Well that leaves not much to discuss apart from perhaps the most important subject if you are not to be labeled a Plagiarist of others work.
A. Have you ever experienced anything like Crohn's Disease or other intestinal tract or Bowel problems?
B. More importantly, have you ever in your Thirty-Four years career treated a Person with Crohn's Disease or other allied symptoms?
C. In addition, the most important piece of information in the face of overwhelming Scientific Proof - the cause is not known and there is no known cure - have you ever cured a Person with any intestinal problems?
Answer. 12. May I answer your questions in order:
Answer. Question 12. A. Although one has to consider this is my truth - Working with the ability of Treating myself with my own treatments, over time I gradually improved what was to become my intense knowledge of my own pre-birth and life history.
1. Which many years ago explained to me - in the last month before my birth; breathing among other considerations was as close to being impossible and taking my life as one could possibly get.
2. Later in life from 1982 at the age of 38 I began to realise the true consequences of this.
3. It was not until the year 2016 at the age of 72 I was truly to work out the consequences.
4. Still today I seek to finely release my-self from the life-time damaging effects of my Father attempting to dispose of me whilst in my Mothers womb; by Punching Mother in the stomach.
5. In May/June 2016 as a result of ongoing treatment I experienced a difficulty of breathing that felt like my very hard and bloated stomach was in my throat and although extremely difficult and indeed frightening, more than I have ever experienced - what breathing I had was coming from the lower part of my stomach and Bowel Movement impossible, sometimes even with a mechanical aid - a laxative.
6. So extreme were the feelings - even with my knowledge of such events I could not: Sleep, Lay, Sit or Stand in any way shape or form for more than a minute or two - until I was able to gather my professional side and talk myself through it, taking some days leading on to a number of Months.
7. The month May 10-June 11th of 2016 was perhaps the worst moments of my entire life.
8. Much worse than the Heart attack I experienced in 1992.
9. Allowing me to experience feel and see the years that had passed since approx. 1968 of difficulty in Passing Motions sometimes as long as three weeks between a bowel evacuation - despite constantly altering my diet to ways that was felt at any given time would work; sometimes they did, but the relief only lasted a day or so sometimes even a week before reverting back.
10. Even medications prescribed by a specialist only worked for a few days.
11. All wrapped around a many decades of Bowel movement problems that appeared to start following the death of my Brother 1968 and more aggressively my Father in 1971.
12. Thus somewhat placed me in a position - for too many years of feeling this was the very beginning of my forty years of bowel movement concerns.
13. Are not we all guided to see the cause of a concern was around the first time the symptoms showed themself.
Answer. Question. 12. B: It was in July 1982 when I started offering Hypnotherapy for Mind Body related concerns.
A. With almost immediate effect I started to specialise in treating People with often a long list of symptoms rather than symptoms that happened to have a Person attached to them.
B.Meaning I was never interested in the name someone had applied; yet who had not been successful in either understanding the Person and their presenting symptoms, or with the magic of Sciense or even other forms of treatment - working only at short-term relieving the symptoms.
C.For me the only therapeutic activity of importance was guiding the Person to find securely stored in their Mind the true cause of any symptoms and assisting them to make sense of the information and in so doing - alter their Entire Body Chemistry. I have to confess; this last part I was not aware that is what we were doing; this came much later.
D. Therefore from my very first Patient on July 11th 1982 a Forty Year old Woman with a range of symptoms of mainly Mind and some physical symptoms.
2. During the first appointment - I only requested a complete list of Mind/Body symptoms and not diagnosed names.
3. From this was created the tools I would use in order to work with her to resolve the symptom list she presented.
4. There was an obvious and very powerful Fear based emotional struggle within her and combined with my lack of experience - leading me somewhat to blindly work to relieve all the symptoms; we did the very best we could as a team and she lived perhaps for the first time in her life to somewhat enjoy; ten years of life.
5. Since that time I have continued to diligently work with many People with many symptoms using ONLY the Person's own words of descriptions - even though we may not always succeed.
6. Many People during this time have confirmed. "I have some form of digestive process from Mouth to Anus concern and it is bad, what do I do with it."
7. Thus without a Medically Diagnosed Name I ever knew whether a Person had: Crohn's Disease, IBS, SIBO, or any other names used to hide up how little is known about a subject.
10. Following subsequent visits and further treatment many confirmed they no longer had the concern and their digestive and Bowel systems are no working comfortably.
Answer. Question. 12. C: Thirty Three years on from this and there are numerous occasions following successful treatment People have recovered from intestinal concerns.
1. No documentation exists, as their recovery is unique to them and of no value to others.
Question. 13: Are you suggesting never once have you knowingly treated a Person diagnosed and previously medically treated with: Crohn's, IBS, SIBO or Hirschsprung's Disease.
Answer. 13: Only once starting in late 2010 a Person presented with Breast Cancer and a number of other long-term symptoms including a lifetime of Irritable Bowel Syndrome - as did her prescribing Doctor.
A. No treatments had every given more than a short while of respite.
B. Recently Aug 2016 - she reported being in very good spirits and virtually symptom free, with the exception of. "Dry:" Eyes, Mouth in the morning and Vagina. following treatment the outcome is awaited.
Question 14: And your own Bowel movement concerns?
Answer. 14: Over the past Three years or so I have experienced some considerable improvement - yet still it is on a fluctuating bases.
A. Having recognised there is a link between my inability to pass motions and my dry nasal cavities and eyes.
B. Recently however there it appears some significant improvement.
C. I have always felt my motions were too dry and that is why I had difficulty passing them.
D. Whilst I was able to makes sense of why - releasing this was by applying the treatment to myself was not without some considerable difficulty.
E. Had I been of the mind set to demand a name to my symptoms it may well have been a symptom of Hirschsprung's Disease.
F. However I am not and have for many years now, recognised my own concern was the sphincter inside my lower bowel - was unable to relax on demand of a full bowel, or the feelings one should experience as a sign to pass motions.
G. This is for me in mid August 2016 not only showing sign of improvement as work in progress it is a very comforting feeling having recognised all those years ago - the Body is only a slave to the Mind and illness only an expression of the thoughts contained in the Mind.
Conclusion. Answer 14: Not least amongst them this past forty years - but for all my life apart from the couple of occasions of having food poisoning, not once have I had any form of Intestine or Bowel Inflammation.
Leaving me to consider had I persisted with prescribed aids for longer than just the one prescription for its course duration - in writing reading and comprehending all of the information contained in this document; that is one might say, the latest information regarding this illness.
The very treatments designed to cure me; would have; if only by lack of secure knowledge made me have an inflamed intestine system and thus susceptible to any one of the diagnoses. I would by Scientific Medicine itself - have been made to have.
Question. 15. Surely that can only lead to requesting you explain the true cause of Intestinal concerns irrespective of the many names or descriptions assigned by medical Sciense.
Answer. 15. Thank you. During the collection and collation of this information; I have to say I am astounded at the amount of information there is available from so many agencies that still use such complicated words and language to explain to People with: Crohn's Disease. IBS. SIBO and the like, they know all about the disorder and if you do as we say you will be ok, yet never are.
A. I have done my best to explain the words used in plain English without destroying the apparent misinformation of so much said about the disorder - yet if one reads and comprehends the enormity and thousands of years of duration of the disorder, the entire medical profession knows so very little in real terms that is of real value - as this paper in their own words admirably demonstrates.
Question 16: May we explore the cause?
Answer. 16. The realism behind this question is - there are as many causes for: Crohn's Disease, IBS, SIBO and Hirschsprung's Disease as there are People with the disorder - however we can make a general understanding that will fit all cases - no exceptions, as we all fit in the same organ no matter what shape size or colour it may be...
A. ...The Skin. We are all contained within the largest organ of the Body, which is driven by the same engine - the Mind and have the same fuel source...
B. ...Food. No matter how we may name it or what our likes and dislikes relating to it are - it is still Food - thus Fuel.
C. To complete this part of making us all the same, we must surely consider perhaps the least studied of all Human and Indeed Animal attributes that despite its expression it is always perfectly balanced making study difficult to impossible - is the entire Body Chemistry, as an entity in itself.
1. As the food we consume is derived from the Earth it would seem reasonable to proffer - the Body, albeit in such trace small values as to be undetectable, is made up of every chemical the world has ever created. Thus the result is unique to every living organism.
D. One has to also consider - if there was but one reason the Body Chemistry is not studied, it is unique to each of us and can totally change its expression in a Heart Beat as instructed by the Mind, based on information received through the numerous senses.
1. Moreover will not following emotional and or physical trauma change back to the original expression - ever.
2. Made more complex if the instructions following emotional and or physical traumas from the Mind, so instructs.
E. In addition - any attempt to interfere with this balance by adding further chemicals will only result in making the entire Body Chemistry alter its expression and in real terms become more toxic and caustic and in so doing in the medium to long-term create more mysterious symptoms or in the case of these disorders Inflammation of the Intestinal Track.
Fear from start to Crohn's Disease - etc.
Question. 17. May we now explore how FEAR is implicated in the true cause...
A. Imposed Traumatic Fear.
B. Cell constriction.
C. Personal expression of Body Chemistry.
E. Intestinal Disorders.
Question. 18: May we now explore the pathway Fear takes with individual Biological Presentations?
Answer. 18. In order to achieve this we must first surely realise; illness causing Fear is not real Fear - it is a product of our negative thoughts we create as a result of emotional traumas - under these circumstances Fear is a real danger, causing illness - thus is not a choice.
There are but Three types of Fear:
1. Natural Protective Fear. Creates a natural Fear response. No unpleasant consequences.
2. Incident Fear. Can create a natural or an Un natural Fear response.
A. Depends on the circumstances or who created the incident and why the incident took place.
3. Accident. Can create a natural or an Un natural Fear response.
A. Depending on the circumstances.
4. One could also suggest there are other types of types Fear and of course one would not be wrong, however for simplicity, we are going to limit this too - Free Floating, there may as a description be a value in this, however if one is unable to explain and resolve why it appears free floating; is there a value in its description.
A. FREE-FLOATING FEAR. Is a term for a generalized sense of fear that is not directed toward a particular object or situation.
Conclusion. Question. 18. 4. A: Free Floating Fear is no more or less than an Anxiety - that following a trauma or set of traumas perceived at origination by the subconscious Mind - to be beyond understanding.
1. Thus the only way it can be dealt with is to attempt to erase from the memory of the Person - the initiating events.
A. Sadly this cannot be achieved, although there may be no image of the event(s) the Person is able to recall, following much and extremely detailed personal or therapeutic searching.
2. In addition the entire Body Chemistry will always remain on high alert and be demonstrated as Anxiety that cannot be relieved - therefore if the attending clinician is unable to make sense of this themselves or for the Person; the Anxiety will constantly move around the Mind and or Body, as the Pain by remaining static will be unbearable.
Fear and the Consequences.
3. Fear is a natural and healthy response to a threat - in order to protect ourselves.
A. Not a Gift for being a good Boy or Girl... embrace it, know it, use it as a strength... do not attempt to "ignore" it!
B. Nor impose it on another Person.
4. Incident Fear lowers the Body Temperature - the Body goes cold, shivers where the Hairs on the Body stand erect. Most times. Will self-repair - leaving no long-term effects.
A. When Incident Fear does not self-repair it will cause Anxiety that is as near to or is permanent, thus is difficult or near impossible to self-relieve.
B. Anxiety is a natural short-term response utilised to warm the Body temperature up, lowered as a result of the Fear in order to protect in flight or fight.
5. When an Incident is deemed by a Person as traumatic - the resulting Fear becomes the foundation ALL illness stands on thus - is a weapon of Self-Destruction.
6. Fear evoked by Emotional and or Physical Traumas based on the Minds perceptive value irrevocably and permanently alters - yet is always maintains perfectly balanced, the entire Body Chemistry.
7. At the same time places a constriction on every cell, Muscle, Vein and Arteries in the entire Body.
8. Traumatic Fear lowers the Body Temperature - which goes cold and/or shivers where the Hairs on our Body stand erect.
A. If this Fear remains it ONLY has long-term and unchangeable effects on both Mind and Body.
9. Anxiety as a result of Fear being evoked is a SHORT-TERM measure to warm the Body, take flight or fight in order for ultimate and ongoing Protection.
10. If the Fearsome experience is not resolved in order for the Anxiety to stop - the Hypothalamus is altered to a new higher temperature rating.
11. The Fear and Anxiety as well as all of the other activity alters the entire Body Chemistry, making it somewhat toxic and or caustic - acidic.
12. Anxiety being a short-term Body activity - most painful physically and emotionally, if permanently running.
A. Insidiously gives over control to other organs of the Body in order to maintain the core and Body temperature. Heart, Liver, Pancreas. Etc.
B. The reality is - no organ is exempt.
13. If the Fear remains unresolved - the Mind responds by permanently altering the Hypothalamus - body thermostat.
A. Like turning up the Heating or Air Conditioning at the same time. Both require more Fuel to drive the temperature Up or Down.
B. Under these circumstances an affected Person can be and often is - both Hot and Cold at the same time and cannot resolve either comfortably.
14. The core temperature of the Body is now in conflict, the internal organs demand more Fuel the skin is now sacrificed in order to protect the internal organs the waste disposal systems go into overdrive and either over produce - Urine-Sweating or under produce - constipation.
A. Under these circumstances Management of Fear will NEVER return the nutrients to the Skin.
15. Which in turn causes other heat creating organs. E.G. heart, liver, Pancreas of the Body to further increase chemical-secretions/activity in order to maintain the Body heat.
A. At this time the exterior of the Body may well feel cold or hot. it is the internal core temperature - unrecognizable by measurement, which has to be maintained.
16. Constriction activity of the entire Body makes delivery of nutrients from food to the Mind/and Body - difficult to impossible.
A. Resulting in the Body being both Toxic and Caustic.
B. This depletes the Body not only of the very fuel required to run the Body - Oxygen, but more important the cell space in the respiring tissues to store Oxygen and at the same time not only increase the carbon dioxide waste, but denies the Body the ability to transport this waste for disposal.
C. Recent findings appear to suggest - the respiratory cycle is actually a three-gas system.
D. Suggesting the third gas - nitric oxide, controls the release of oxygen from red blood cells into the body tissues.
E. Studies have shown that haemoglobin - the protein in red blood cells that picks up oxygen from the lungs - also needs to carry nitric oxide to enable blood vessels to open and supply oxygen to the tissues.
F. In addition. "Blood flow to tissues is more important in most circumstances than how much oxygen is carried by haemoglobin.
Conclusion. F. Of course one may argue this is too simple and of course they would be correct for the process from Fear affects every one of our Body chemicals (circa 2000-4000) in a Pyramid Style.
A. Moreover every one of the chemicals are implicit in the running of the Human Body and every illness symptom - including Crohn's Disease, IBS, SIBO and Hirscprung Disease.
B. One affects two, two affect four, four affect eight and in just forty-eight or so changes there has been enough chemical cell activity to build another Body - trillions of chemical adaptations - all from Fear.
18. Thus our emotions are implicated in illness but only if in the case of illness they are seen as Symptoms and never the Cause.
19. Fear being as the creation of every illness known to mankind and the reason why there is not one cure for any of the approximately 100,000 illness in the world and Modern Medicine does not have a clue as to the true cause of one of them and more importantly does not have a single disease modifying treatment.
20. Thus all illnesses are mysteries - no exceptions.
21. It is not me now or ever being Vexatious - it is information as supplied and well published on a worldwide bases by the Medical Profession themselves.
22. It is just because so few People have the courage to say or demonstrate Scientific Medicine is a Failure - that we have to continue to accept the failures as scientifically proven.
23. Fear under these circumstance becomes a intestine restrictor - thus affects the entire digestive systems, including the last sphincter before the anus thereby restricting its evacuation value and in so doing renders the entire Intestine System inflamed or on a local bases - depending on the thought process from the Mind creating the symptoms.
Question. 19: I have selected just two items I would like further information on?
1. Why is it more People are getting negative intestine symptoms these days.
2. It is reported - Some Children develop Crohn's Disease in the womb.
Answer. 19. 1: One must not do as I am about to; as it opens up to discussion-distracting views, as the content would be labeled as Confrontational or without evidence to demonstrate the points raised.
A. Of course this would be true as there are many historical incidents one could set a datum point too.
B. However we must start somewhere in order to answer this intriguing question.
C. On September 11th 2001 an incident occurred in the United States of America that had such implications as to change the world forever.
D. Of course many People would agree with this and many would not.
E. Based on their own personal Emotional Phenotype reaction to the News that covered the world's television radio and other News Medias and still as a result of the belief by many - this was a self-inflicted wound on the American People.
F. My interest and view is only with Health Concerns.
G. I feel fairly comfortable in saying there for a time and still it exists today, made worse by so many other factors - a FEAR of enormous intensity instilled in People of all colour's, race and creed that is at the center of the increase in digestive symptoms in so many People.
H. Recognised by - this disorder is caused by Fear, which in turn causes Anxiety and if this Fear is not resolved - will cause illness of the Digestive track and intestines of a Person so disposed.
I. Whilst it may well be argued Fast or Poor quality food is the cause of all of this and may well be a serious contributory factor - one has to consider why People will consume such food items when it is well known in the main they are nutritionally devoid.
Conclusion. Answer. 19. I: The serious possibility exists as we Humans are the finest chemical annalist the world will ever see - we intrinsically know there is copious amounts of Fat and Sugar's contained within the products - both of these foods are either energy giving or Insulators against cold; brought on through FEAR.
Answer. 19. 2: Whilst it surely must be recognised to effectively treat Children that develop Crohn's Disease in the womb is difficult to impossible as treating them in their formative years - if this situation is never investigated and satisfactorily answered - how will a Person at any age be treated and managed well - if not cured.
Question 20: It is not my desire to be patronising on People with illness or any Person in the medical profession seeking to assist a Person during their suffering - sadly; and I have heard the comment so many times it as laughable as is the comment...
"...If you have never had the disorder you cannot possibly understand."
B. May I set the record straight - No one ever long-term, "becomes" ill following a viral infection, no more than from: Environmental Factors. Genetic Predisposition, an adaptive immune system. Abdominal Pain. Diarrhea. Fever. Weight loss. Or rather complications that may occur outside the gastrointestinal tract including: Anemia. Skin rashes. Arthritis, Inflammation of the eye or feeling tired. As it is often suggested Crohn's Disease is.
C. Although we accept so many People never appear to recover from what is commonly and somewhat mistakenly labeled as A Viral Infection.
D. The real truth is whatever symptoms that persist are no more than that and more importantly no more than a continuum from the earlier Mind related cause still unresolved and seeking understanding through ever changing and mysterious out of nowhere symptoms.
Conclusion. Question 20: A Viral Infection is not an infection at all - it is an expression of the entire Body Chemistry; as is Crohn's Disease. Medical Science cannot possibly makes sense of, as it is not only unique to each and every one of us we only have to look at an object whether we like it or not and our Entire Body Chemistry will alter and if this item we look at is somehow of a traumatic nature - then the entire Body Chemistry will be set for life; in a heartbeat.
Question. 21: One item I hear so often from People and indeed Therapists as a therapeutic application or a revelation a Person makes as to how their life will be run from a life changing point with - being Grateful?
A. Do you have a view on this?
Answer. 21: Nice observation, yes it is something that I hear quite a lot of...
...Grateful as a Personal or Therapeutic response...
1. Feeling or showing an appreciation for something done or received.
2. Warmly or deeply appreciative of kindness or benefits received.
3. Being grateful to another for their help.
4. Expressing or actuated by gratitude: a grateful letter.
5. Pleasing to the mind or senses; agreeable or welcome; refreshing: a grateful breeze.
Question. 22: Does Grateful fit into your therapeutic remit and if not why?
Answer. 22: Following and even during treatment at no point is a Person expected to be Grateful for anything.
A. Even if by a stroke of good fortune - they are not paying for treatment.
B. It is clear on reading this collection of information relating to intestinal disorders and one could add any other illness whether it has a name or not - the only approach currently available as there are no disease modifying (Cures) currently available as the cause is not known or accepted - for any illness; is Symptom Management.
C. Thus one has to include being Grateful - is no more than a management tool in the absence of a cure.
D. Thus when therapeutically applied - is mainly for the practitioner's anxiety relief and never the Patient.
C. Symptom management is never in Talking Cures therapeutic remit.
Question. 23: May we explore this interesting concept?
Answer. 23: Yes of course. More than ever today - Facebook and the many other Social Media forums are being seen as almost a first-line source of information supply and a somewhat secure manner of asking questions and receiving answers from online friends - or not so readily available from practitioners.
A. May we accept this as an example to which I may respond too.
Consider a Person nominated online to post three things to be Grateful for:
1. Being grateful to be alive and in good health.
2. Being grateful for family and friends.
3. Being grateful for the inner gifts to have been blessed with, in particular a positive mental attitude, which has allowed overcoming - the many challenges faced in life so far.
Conclusion. Question 23: Are they not Fundamental Rights of Life not gifts for being a good Boy or Girl to be forever Grateful.
A. Would this reply not rightfully so - leave a Person quite unsure what this means...
B. Whilst I agree with the dictionary explanation of Grateful, Is it not fair we put it into perspective.
1. It is a Fundamental Right to be Alive and in good Health, does not traumatic Childhood events, attempt and so often with ill health - take away this right.
2. When it comes to family and friends, they surely are not Heaven sent gifts.
A. They are often part of an ongoing process of enjoying one another's company and debates.
B. Thus, they are a joint effort having been worked for - over perhaps many years.
3. Surely it is confirmation enough - the inner gifts one has been blessed with, in particular a positive mental attitude has allowed an ability to overcome the many challenges faced in life so far.
A. Is it not a clear demonstration of answer 1 and 2 as well as being a demonstration of an Integrity and Wisdom possessed, way before the many challenges and obstacle's placed in the way, in the light of the negative aspects of such traumas demonstrated with Creativity being the Brakes on Madness as a or the way - to deal with them.
This should leave a Person in an unassailable position.
B. Surely this is not something to be Grateful for it is a well-earned right returned as a result of overcoming serious life style removing or threatening obstacles.
Question. 24: Interesting observation, which one would not seek to disagree with.
A. The Right for a Parson to be grateful for their life...
B. The Right to be Grateful for People that have come and gone in life...
C. The Right for the experiences - good, challenging or difficult which have enriched a Person...
Answer. 24: That is what I like to hear - well done is in order, may many others follow such a fine example.
A. Failing this - being Grateful rather like always saying Sorry for no apparent reason; thus is a weapon of self-destruction; that is only effective as long as one keeps up the pressure of feeling and being Grateful.
Conclusion: I find it extremely patronising on People with any illness - they should practise being grateful for so many institutions including leading Patient information portals, still proudly and with all the scientific style proof, proclaim, to have all of the information required as to - What causes intestinal disorders. Suggesting - they are caused by if we may be simple - inflammation or muscles that have lost the ability to relax.
Yet not have the integrity and wisdom required when stating in such a profound manner...
"Intestinal disorders are caused by inflammation and muscle spasm."
Followed by. "It is not known why the inflammation and spasms occur."
To ask themselves or even suggest...
"...Why we say this we do not know, but we are Change and are going to research this important question.
In addition - have the audacity to have a Shop Link to products for it appears a Person or Family Member to purchase in the vein hope the symptoms will be eased by self-management...
...Thereby confirming there is no intention of ever finding a cure.
Question. 25: Understanding that treating Crohn's Disease and related Intestinal Disorders with Talking Cures is not available to everyone, no more than People would be able to accept it is caused by a Process of their Mind - is there information that you have found in your research and writing that may be of interest to others?
Answer. 25: Interesting question. I have to say in all of my now Thirty Four years of treating People with multiple and mysterious no known cause and no known cure symptoms - never once has it come to my attention a Person has been cured of any intestinal disorder.
A. Cured = No more illness and no more Medication or dietary management required.
B. Following your asking the question; I did a simple internet search with. "Has any Person ever been cured of Crohn's Disease." One response came to my attention which contained this. "So last year, Robert stopped all his medication and took three slices of 12-day old crusty loaf, added a couple of spoons of milk and artificial sugar and heated the mixture in the microwave.“
C. "I had a very serious case of Crohn’s Disease and now it has gone completely and I can eat normally without worrying."
D. I take my miracle cure on a regular basis to keep everything under control and I have amazed my Doctor.”
E. It appears current published research in medical journals about the Crohn's Disease still is very suggestive of there is no known cure.
Conclusion question. 25: Surely if Robert has indeed found in his mind a cure for his incurable disorder than all power to him - however it is equally important we do not miss item D as this clearly suggest Roberts cure is of a management style - leaving one to question; what is he stops taking the bread and milk and as we are all aware management of symptoms does not last very long.
Question. 26: Were you able to make any conclusions from the findings?
Answer. 26: Yes there is - however; first I am obliged to say I support any intervention that shows promise.
A. Scientifically Proven or not - for surely we must all keep an open mind if medical science and the pharmaceutical companies say with Scientifically Proven Certainty. "There is no cure;" after many years have they not been telling the world; a Cure is what they have been searching for.
B. The conclusions I was able to make lead me to ask. "Has Robert really cured the Crohn's Disease or found a lovely way to keep the ever pervading symptoms at bay."
Question. 27: So if we resolve the possibility these mysterious symptoms that appear to cause so many illnesses - is not created by the very medicines we take to cure the illness, what do you feel is the answer?
Answer. 27: All illness no matter what name it is given has but one purpose.
A. Following Childhood and even in the womb Emotional and or Physical Traumas a Child's Mind as a Protection - creates illness.
B. Give all symptom presentation whatever name appears to fit and this illness has a purpose.
C. Firstly we have to accept all illness is a Protection a Person displays to ensure the same traumas cannot or do not ever happen again.
D. Thus the resulting illness is an advantage not a disadvantage.
F. The purpose of any illness is for the People that created the Traumas to Understand what they have done and make amends. (See Link) Understanding
G. When such times as this Understanding is not received the requirement simply takes another pathway.
H. Therefore the symptoms named as Crohn's Disease is no more than an expression of the entire Body Chemistry (link) Illness or Toxic Shock demonstrating their negative effect in the digestive and intestine systems caused by Fear that is never resolved or Understood.
Answer. 25: The clue to this is in the comment 50% of cases.
A. This works on the well known 80/20 rule.
B. You can kid 20% of the People some of the time and 80% of the People all of the Time but you cannot kid all of the People all of the Time.
C. This means some of the People say 50% will feel if only temporally they have been cured and the other say 50% will not be. Demonstrated by; if any other symptoms related or not exist there has been no cure.
D. A complete demonstration - Illness is an advantage not a disadvantage - and do not take my illness away from me I will not know what to do with the time.
E. Resolve the Fear to the Minds satisfaction and it will alter the Entire Body Chemistry.
Kindest regards and best wishes.
Peter Smith Talking Cures
Is it not worthy of consideration - it is a fundamental right; not an emotional gift to which one has to be eternally grateful, to question and even chastise medical research or institutions that are continually digging the proverbial hole in pursuit of improving health care outcomes Persons.
Moreover it is a right removed if one joins them in the hole and not only continues digging but attempts to fill in the hole at the same time
We all have a lot to teach and a lot to learn and learn we must.
This is my truth now tell me yours - change someone's Mind.
...In illness - The Mind/Brain/Body is not in the slightest doing something wrong, it is desperately trying to right a serious and terrible wrong?
"No apologies are made if this paper is seen as repeating or simplistic, for too long Scientific Medical Papers have been written in a manner no one truly understands, if this were not so, cures would have long since been found making this paper and Talking Cures unnecessary or redundant.
Whilst it must be recognised, the framework - part of the content, for this paper is in the public domain and credit given to the authors;
Peter Smith Talking Cures asserts the right to be recognised as author and Intellectual ©Copyright holder of his contribution to this document."
"Chromes Disease. Explored Understood Explained." Author Peter Smith Talking Cures Copyright 17th August 2016.
Thus, in keeping with the generosity of many contributors - this document is free to use as an Education or Patient led assistance - in its entirety.
Talking Cures is a Twenty First Century Medicine...
...able to treat multiple symptoms of Mind and Body in a Person.
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