Explored Explained Understood?
One may term this as hiding
from the truth as we all appear to do - when mysterious
This Paper is as much of
what is reasonable to consider - as it is a matter of
It is also a compilation of
two papers - one Wikipedia and from another professional
self-help style source.
Therefore it may contain a
number of repeats - perhaps this particular set of
mysterious and distressing symptoms, demands such scrutiny.
Moreover, for a Medically
qualified Person considered as.
Anecdotal - a posh word for storytelling.
If in reading this paper my
writing appears to be like a foreign language or even
Consider reading this paper
- not as a book; take some time to comprehend the contents.
Where I would like to think
and feel sure, it will make sense?
So often we read or hear in
detail "What" (description or
symptoms) of an illness - but rarely if ever does anyone
take the time to truly explain.
"WHY," or how it is really
...this paper is designed to
answer many of the questions - we are so often left with.
Where many times we have the
questions and no answers - or the answers and not the
If I have unwittingly left
anything out or not satisfactorily answered, please email
(address at the end of this page) and I will include it in
this Paper at the earliest opportunity.
Please include item number
or a copy and paste if possible - of the item that is not
not all struggle as a Child to learn many things we now
through the experience of life - are now extremely competent
No apology if offered if
discussions are repeated within this paper.
The understanding for this,
is nothing is more repeating than illness that is there
every day of one's life and - despite treatments does not
get better or have a satisfactory explanation/understanding
or when Medical Science writes Scientifically Proven Papers
about illness; in a confusing or repeating manner that
confuses everyone - even themselves!
The first thing in the
process of answering this is, for any one suffering, it is
"...New understandings are
required about illness..."
...as it appears the existing education is the same
If on reading this or any of
Talking Cures understanding of illness one gets the
impression I am angry - then please believe it; because in
2016 People are not only not recovering from any illness -
so often the treatments make them worse and no one knows why
or it appears cares.
From Talking Cures point of
view and therapeutic practice - names of illness especially
Medically Diagnosed recognised and Scientifically proven,
are of no real value in the understanding and treatment of
any illness - the only Name we should use or symptom we may
Person is unable to achieve a Healthy and satisfactory
...Or never allowed to
become the Person they should have...
“Specialised assistance,” in order
to make sense of the presenting symptoms, the cause and
reason for them - enabling automatic resolution via the
Persons own immune systems and Body replication process -
referred to as, the entire body chemistry.
...Surely if a Person cannot
be in control of self-repair when can they be in control!
To a trained Medical Mind
these questions and answer updates may well appear or feel
patronising - it is hoped not, as their structure is at the
very. "Heart" of the success of Talking Cures as a
therapeutic application and may well be a serious asset and
improvement in Medical Treatment outcome success.
to fully appreciate this, it is helpful to consider and
All of the information as to
why a Person became ill in the first place and as a
consequence - all of the information required for them to
automatically create immune response repair is - not only
contained within the confines of their Mind - it is the only
information required to bring about the required Automatic
Cure using their own immune systems and Body replication
processes. As designed by the Mind and
By creating very cleverly
constructed questions - knowing the Person is able to answer
them with their own knowledge of themselves of which they
are a Master and if they are unable to with my
interpretations, accepted as re-education of their own
information, that continues/completes on an ongoing bases;
the process either returning to well-health or well-health
for the very first time in their lives.
These explanations are from
a collection of Scientifically Proven papers in the public
domain and discussion forums and are in a Question and
Answer forum style.
It is important to accept I
am both the Questioner, on behalf of interested Person's as
well as the Person supplying the
...thus in many ways -
my own best critic.
Leaving one to choose the
Questions and Answers that are important for a better or
individual understanding of this seemingly mysterious
of Wikipedia, the free encyclopedia:
This article is about making
2016 sense of the disorder.
Regarding Person's having
TMAU and interrelated symptoms all with unknown cause and no
Classification and external resources
4835 Gene Reviews
Trimethylaminuria - No data
has been found on Wikidata.
As there is so little information relating to this simple to
understand disorder - may we accept this is a brief outline
of the history of the disorder - opening up the way for
Trimethylaminuria, has been around for centuries, but has
only gained scientific recognition and support in the past
The first clinical case of TMAU was described in 1970.
Trimethylaminuria is a rare disorder in which the Body's
metabolic processes fail to alter the chemical
Trimethylaminuria is a metabolic condition in which an
individual is not able to convert trimethylamine into a
compound called trimethylamine N-oxide.
Trimethylamine N-oxide does not smell.
Trimethylamine is notable for its unpleasant smell.
It is the chemical that gives rotten fish a bad smell.
When the normal metabolic process fails, trimethylamine
accumulates in the Body and its odour is detected in the
Person's sweat, urine and breath.
The consequences of emitting a foul odour can be socially
and psychologically damaging among adolescents and adults.
The genetic or primary form of this disorder is transmitted
as an autosomal recessive trait.
The metabolic deficiency occurs as a result of a failure in
the cell to make a specific protein, in this case the enzyme
flavin-containing monooxygenase 3.
Enzymes are nature's catalysts and act to speed up
Without this enzyme, foods containing carnitine, choline
and/or trimethylamine N-oxide are processed to
trimethylamine and no further, causing a strong fishy odour.
A secondary form of Trimethylaminuria may result from the
side effects of treatment with large doses of the amino-acid
derivative L-carnitine (levocarnitine) or choline.
This secondary form of the disorder is a result of an
overload of trimethylamine.
In this case, there is not enough of the enzyme to get rid
of the excess trimethylamine.
1: As there is so little information relating to this
disorder - may we explore what there is, starting with the
so called Signs and Symptoms?
Signs and Symptoms.
1: The fish-odour smell is the obvious symptom,
otherwise affected individuals appear normal and healthy.
Trimethylamine builds up in the Body of Patients with
The trimethylamine is released in the Person's sweat, urine,
reproductive fluids and breath, giving off a strong fishy
Some suggest it seems to be more common in Women than Men,
but scientists do not know why.
Scientists suspect that
Female sex hormones, such as progesterone and/or oestrogen,
There are several reports that the condition worsens around
In Women, symptoms can worsen just before and during
menstrual periods, after taking oral contraceptives and
Moreover with Trimethylaminuria have a strong odour all the
time, but most have a moderate smell that varies in
intensity over time.
Other than the strong fishy odour, individuals with this
condition typically appear healthy.
2: Is that it?
2: It appears so - makes one wonder why it takes a
Professor to make this diagnoses.
3: May we now look at what is suggested is the cause?
Trimethylaminuria is a rare metabolic disorder that is
inherited as an autosomal recessive genetic trait or
It is suggested People with Trimethylaminuria have an
impaired version of the enzyme flavin-containing
monooxygenase 3 (FMO3.
This is the enzyme that converts trimethylamine to
FMO3 is produced by the liver and is a member of a family of
similar enzymes responsible for metabolizing compounds that
contain nitrogen, sulphur, or phosphorous.
The enzyme is coded for by the FMO3 gene.
Trimethylaminuria may be caused by a variety of genetic
changes to the FMO3 gene.
Not all of the functions of the FMO3 enzyme are known,
so physicians do not know
what other symptoms besides odour may be associated with
Or occurs as the result of treatment with large doses of
dietary precursors of the offending chemical - secondary.
Symptoms develop when the ability of the liver enzyme -
flavin-containing monooxygenase 3 to break down -
metabolize, trimethylamine is inhibited.
The responsible gene, designated as FMO3, has been tracked
to gene map locus 1q24.3.
Although humans have several FMO genes, changes in only one
of these, FMO3, causes Trimethylaminuria.
For reasons that are unclear,
many different changes - mutations) of the FMO3 gene exist.
Carry the genetic information for each individual.
Human Body cells normally have 46 chromosomes.
Pairs of Human chromosomes are numbered from 1 through 22
and the sex chromosomes are designated X and Y.
Males have one X and one Y chromosome and Females have two X
Each chromosome has a short arm designated “p” and a long
arm designated “q.”
Chromosomes are further sub-divided into many bands that are
For example, “chromosome 1q24.3” refers to a region on the
long arm of chromosome 1, within the band 24.
The numbered bands specify the location of the thousands of
genes that are present on each chromosome.
Genetic diseases are determined by the combination of genes
for a particular trait that are on the chromosomes received
from the Father and the Mother.
Recessive genetic disorders occur when an individual
inherits the same abnormal gene for the same trait from each
If an individual receives one normal gene and one gene for
the disease, the Person will be a carrier for the disease,
but usually will not show symptoms.
The risk for two carrier Parents to both pass the defective
gene and, therefore, have an affected Child is 25% with each
The risk of having a Child who is a carrier like the Parents
is 50% with each pregnancy.
The chance for a Child to receive normal genes from both
Parents and be genetically normal for that particular trait
The risk is the same for Males and Females.
All individuals carry a few abnormal
Parents who are close relatives - consanguineous, have a
higher chance than unrelated Parents of both carrying the
same abnormal gene, which increases the risk of having
Children with a recessive genetic disorder.
4: What does this tell us?
4: Above under "Causes"
I have marked four items in Red and here I have re written
them to make a little more sense and for further
"...For reasons that are unclear,
physicians do not know if or why large doses of dietary
precursors create other symptoms and what it means when they
the nucleus of Human cells carry the genetic information for
5: Who are in the main are affected?
Trimethylaminuria is a rare metabolic disorder. More than
100 cases have been reported in the medical literature.
Some clinicians believe that the disorder is under-diagnosed
since many People with mild symptoms do not seek help.
However, some physicians do not recognize the symptoms of
Trimethylaminuria when a Person with Body Odour seeks a
Why is it Doctors believe the disorder is underdiagnosed.
Is there a Diagnostic Formula?
There is a sadness here for all of the careers of our
dedicated front line clinicians they have been forced to
believe; we humans do not have a Mind only a Biological
Brain - thus can be medicated.
In pursuit of this - have adopted various protections, when
their scientifically proven treatments fail to achieve the
desired or promised outcome. EG: "Its all in your Head." is
the one required here.
Therefore when a Person has any disorder let alone one as
personal as TMAU - knowing deep in their Mind it was caused
by their Parents and exacerbated by their closets family and
Friends, the very last thing they desire is to be
further ridiculed by a Person in
their professional capacity, considered - tantamount to a
D. Thus are in perpetual Fear of
attending their Doctors or any professional - whether they
have secure knowledge or not about the condition.
The presence of the rotten-fish odour is indicative,
especially in severe cases.
However, diagnosis based on smell is
unreliable because the odour is often episodic and not
everyone can detect the smell of trimethylamine.
In addition, on the basis of smell, Trimethylaminuria can be
difficult to distinguish from other
conditions that give rise to an unpleasant Body Odour.
Diagnosis is based on urinary analysis of trimethylamine and
trimethylamine N-oxide, which can distinguish
between severe and mild cases.
Urine analysis after the
administration of large doses of trimethylamine can
distinguish carriers of the condition from unaffected
Testing can be done by giving choline by mouth followed by
urine collection a certain number of times over a 24 hour
Urine testing should be performed on two separate occasions
when the individual is on a non-restricted diet.
The test measures the ratio of trimethylamine to
trimethylamine N-oxide present in the urine.
Genetic testing is available to distinguish between primary
genetic Trimethylaminuria, which will result in severe
symptoms, from secondary, non-genetic forms of the disorder.
7: How may we interpret the Diagnoses information?
7: We do not - it is just information a Person would
be able to supply, if one asked the correct questions.
8: Better explanation please?
8: This is no more than a relief of the attending
teams own Anxiety demonstrated by a Person being delighted
for a brief moment in time at the confirmation their problem
is biological not. "All in their
9: Are there currently any therapies offered?
Standard Therapies and
The following are some ways a Person with Trimethylaminuria
can lower symptoms of odour: It is suggested. In mild cases,
symptoms are relieved when foods containing choline and
lecithin are restricted.
Some severe cases may require the administration of a
gut-sterilizing antibiotic such as metronidazole.
This treatment reduces the number of intestinal bacteria
that break down choline and trimethylamine N-oxide into
Avoiding foods containing trimethylamine and its precursors
(choline, lecithin and trimethylamine N-oxide).
Trimethylamine is present in high levels in milk obtained
from wheat-fed cows Choline is present in high amounts in:
Eggs. Liver. Kidney. Peas. Beans. Peanuts. Soy products.
Brassicas - Brussels sprouts, broccoli, cabbage and
cauliflower. Lecithin and lecithin-containing fish oil
In the case of mutations that do not completely abolish FMO3
activity, supplements of riboflavin might help maximize
residual enzyme activity.
Dietary supplements such as activated charcoal and copper
chlorophyllin Activated charcoal taken at a dose of 750mg
twice daily for ten days.
Copper chlorophyllin taken at a dose of 60mg three times a
day after meals for three weeks can bind trimethylamine in
the gut and hence reduce the amount available for
Taking low doses of antibiotics to reduce the amount of
bacteria in the gut. This suppresses the production of
trimethylamine. Taking riboflavin (vitamin B2) supplements
to enhance any residual FMO3 enzyme activity. Recommended
intake is 30-40mg taken 3-5 times per day with food.
Taking laxatives can decrease intestinal transit time and
reduce the amount of trimethylamine produced in the gut.
Taking supplements to decrease the concentration of free
trimethylamine in the urine.
The use of slightly acidic soaps and Body lotions can
convert trimethylamine on the skin into a less volatile form
that can be removed by washing.
If the disorder is acquired due to excessive doses of
L-carnitine, choline or lecithin, symptoms disappear with
reduction of dosage.
It is important that a person who has Trimethylaminuria
follow the treatment advice of their health care provider.
They should not attempt to self-administer these treatment
Medications and supplements can have unintended
interactions, and dietary restrictions can result in
Choline is essential for nerve and brain development in
fetuses and infants, therefore, pregnant and breast-feeding
Women should consult with their health care provider before
restricting their dietary choline.
Trimethylamine N-oxide is present in seafood - fish,
Freshwater fish have lower levels of trimethylamine N-oxide.
Using soaps with a moderate pH, between 5.5 and 6.5.
Trimethylamine is a strong base (pH 9.8), thus soaps with pH
closer to that of normal skin help retain the secreted
trimethylamine in a less volatile form that can be removed
Avoiding factors that promote sweating, such as exercise,
stress and emotional upsets.
Behavioural counseling to help with depression and other
Genetic counseling may be of benefit for Patients and their
Genetic counseling to better understand how they developed
the condition and to be aware of the risks of passing this
disorder on to the next generation of Children.
However, research suggests it is possible for People with
this condition to live normal, healthy lives.
10: Can Trimethylaminuria be cured by replacing the
10: Unfortunately at this time, enzyme replacement
therapy with the enzyme FMO3, which when absent,
is believed to cause the condition, is not an option
in the management of Trimethylaminuria.
11: Is there a value in Human Bio molecular Research?
11: It appears there is Research being carried out
into Human Bio molecular characteristics of TMAU. It appears
the recommendation is working with a medical or genetics
professional to contact the laboratories for further
Trimethylaminuria can be very upsetting, potentially
affecting a personal life and career.
Depression and social isolation are common.
Counseling may help you cope with any depression and other
As the researcher also suspect that stress and diet play a
role in triggering symptoms.
12: Are there any points of interest in this section?
12: Forgive me for repeating. This is no more than a
relief of the attending teams own Anxiety demonstrated by a
Person being delighted for a brief moment in time at the
confirmation their problem is biological not. "All in their
13: Expand this please?
13: Accepted there are perhaps only 100 cases world
wide making study very expensive; is it really acceptable
after some Forty Six years so little is understood about the
condition - when one considers Man and
indeed Woman have experienced Body Odour's for as long as
mankind has occupied this planet.
In addition any clinician
that has to consider the Family in any treatment application
is surely to be considered - out of their brain and has and
will never have any comprehension of this very sensitive
14: What if any investigation are being conducted
into other therapies?
14: It appears there are a number of investigations
Whilst not exhaustive it was not easily - other that
Wikipedia to source any information that expanded on the
knowledge and treatment of this disorder.
Further searching confirmed...
To date there has been no systematic
appraisal of suggested treatments in this condition.
Moreover it seems clear the various
options have not been universally successful particularly in
severely affected individuals.
At the very least, Patients may benefit from being warned
that the symptom may be exacerbated by febrile fit or
febrile convulsion - is a seizure associated with a high
Body temperature, without any serious underlying health
issue. including infections and during the pre menstrual
Some People with Trimethylaminuria experience depression and
social isolation as a result of this condition.
It appears to me this is a far as investigations will ever
go with this most distressing of disorders - more than ever
medical advances are driven by the requirement of big
profits - thus this as many will disappear into the history
book of Novel but of No Scientific
15. May we examine the Genetics implicated in the
Understanding of this disorder? And is it inherited?
Research suggests. Trimethylaminuria is usually inherited in
an autosomal recessive fashion, which means that two
non-functioning FMO3 genes are usually needed for a Person
to have symptoms.
Both Parents of an individual with Trimethylaminuria, are
"carriers" of the condition, in other words, they both carry
one copy of an altered gene for FMO3.
Since this condition usually requires two altered genes to
cause symptoms, typically neither Parent of an individual
with Trimethylaminuria has any symptoms.
Sometimes, "carriers" of one copy of an FMO3 mutation may
have mild symptoms of Trimethylaminuria or have temporary
episodes of fish-like odour.
Due to the variability of symptoms People with
Trimethylaminuria experience, researchers think that
different genetic mutations in FMO3
can influence the symptoms of the disease, affecting time of
onset and how strong the odour is.
A carrier of this condition can be identified by the.
"TMA challenge" or a "TMA load"
This involves giving an individual a 600 dmg pill of
Carriers of Trimethylaminuria excrete 20-30 percent of total
trimethylamine as the free unmetabolized amine and the rest
as trimethylamine N-oxide.
Non-carriers excrete less than 13% of the dose as
Gene testing called gene sequencing can be used to look for
mutations in the FMO3 gene.
Note: One may be advised to consider
Gene testing is currently available only through research
laboratories thus may have a long waiting list and not
accept direct contact from Patients.
16: Loads of nice interesting information collated
from sources that deem to know about the disorder having
studied it - through from Genetic to Symptom presentation
and on to clinician and self management; presented in a
But has it or does it give
any hope in the true understanding for a Person with the
disorder and if I have to - include the many People
surrounding such a Person?
16: My initial response including watching a
professor consulting with young Woman with the disorder on
National UK Television - is not a chance.
17: Leads one to request you explain your
observations and perhaps interaction if any with anyone from
the medical profession or even Persons with the disorder?
17. May we start with my interactions with others.
As far back as 2007
following a television program I wrote to many - copied
below, significant People; who all are implicated in - so
they say, finding the cause and an effective treatment or
Of course I have to
recognise I am not medical qualified - but with any
mysterious disorder that is
scientifically proven to not know the cause and have no
...I have to wonder the
value in being medically qualified and why my opinion is not
even worthy of a polite - thank you, but no thank you.
107 Victoria Road
Southend on Sea
Essex SS1 2TF
Telephone-Fax - 01702 60 30
25th September 2007.
Dr Robin Lachmann
University College London
Dear Dr Robin Lachmann
Re: “Help I smell of Fish”
Re: Fish Odour Syndrome.
Please receive the enclosed
letter for forwarding on at your discretion to - any Person
with this mysterious symptom - Rachel the 32 Year Old Lady
who appeared on the above mentioned TV Program with you, as
well as in your surgery at the UCL.
Whilst I have no previous
knowledge of you there is no doubt in my mind like all
Medical Staff whether within our NHS or private you are a
fine and dedicated Doctor who would always wish to adhere to
the Doctors premise of. “First do no
harm” and in consideration of what I am about to
request you do, this must come to your mind, it certainly
If I was a Doctor I would
take great stock in saying to my Patient. “I have done some
research and found a Therapist that may be able to help
You are invited to take the
credit in this case.
In consideration of the Fact
in your own words; “there is no cure” for the above
I would request first you
talk to me - or at the very least forward the enclosed
letter to Miss Rachel as an representative of the Three
Hundred or so Sufferers in the UK left in the
wilderness of no Scientific Evidence
to help them, or better still under the guise of
Scientific Research - refer her to my practice instead of
leaving her to the ravages that could be reasonably expected
to continue to destroy her life.
For this statement; whilst
from a Scientific point of view may be true, for Talking
Cures the same consideration is most certainly not true.
One could and should
consider what harm can talking do, surely it is not in the
same league as administering Drugs: thereby no side effects,
Inserting Needles, no inadvertent infection or some form of
Manual Manipulation, twisting a Body until it clicks in the
belief the louder the click the more beneficial.
Talking Cures are a powerful
stand alone treatment regime that does not rely on any form
of instructions - relying on the Patients response to a very
clever conversational technique based on secure techniques
and understandings - Diet or Life style changes, as was the
case with Mrs. Carol Sexton who was also featured on the
Such changes imposed upon a
Person as a therapeutic application with a mystery disease
as this, will only create an illness with the possibility of
the new illness being, just, if not more mysterious and by
definition even less curable.
This is not to be seen as a
derogatory statement about the Psychologist Mrs. Sexton
Being able to be fresh of
the Body is a Right not a Gift, much the same a sleeping
soundly; knowing one has done ones best in any given or
It would be reasonable to
expect, Rachel to be delighted to know there is at least One
Person interested in her plight, with the belief her
condition can be cured.
Your response is awaited
Mr Robin Lachmann UCL London WC1E 6BT
CC: UCL Director. Professor
Roger Lemon, BSc, MA, PhD, FMedSci
CC: Medical Research
CC: General Medical Council.
CC: BBC 3 Television.
Treatment for: Sports
injuries. HIV. Backpain. Accident Injuries. Whiplash. Muscle
Aches. Allergies. Obsessive-Compulsive Disorder. Repetitive
Strain Injury. Stress. Tiredness. Attention Deficit
Disorder. Emotional Pain. Asthma. Fibromyalgia, Substance
Abuse. Family Counseling. Fears. Phobias. Anxiety. Feminine
Concerns. Infertility. Any discomfort of the Mind and Body
where the degree of comfort desired has not been achieved.
Telephone Treatments by
Answer. 17: Continued.
To: All members of TMAU
Subject: Channel4 - Still
looking for TMAU volunteer
Date: Wed, 6 July. 2011
The following is an e-mail
sent to you by an administrator of. "TMAU Forum
Message sent to you follows:
Please see below email
requesting a volunteer for channel 4 documentary.
Another opportunity for
media exposure, includes help from Dr Lachmann.
Main criteria is newly
diagnosed & who has not had any dietary intervention.
I believe some of you have
already been discussing this program in the forums.
Please keep us updated in
the forums if you are going to appear!!
On a separate matter please
see latest posts from Malory in the forum: Board index -
latest news and announcements.
Thanks to Malory - keep up
the good work!
I am working with Vicki
Cooper - who I know contacted you last year regarding
Embarrassing Bodies and covering TMAU and you were extremely
helpful putting out the word for her to find a contributor.
I wonder if you might be
able to help again?
Vicki and I are now working
on a specialist factual series for C4 called. 'Food
The series is looking at how
specific diets impact and in some cases cure, certain
We are interested in
metabolic diseases and would very much like to feature TMAU
in order to raise awareness of the condition.
Once again we have Robin
Lachmann on board to offer his expert support.
Would you be able to put up
a Media Request?
We are looking for a
contributor with newly diagnosed TMAU - confirmed through
urine test and yet to start any dietary intervention.
We would like to find
someone as soon as possible - preferably in the next 2
The contributor would come
to the Food Hospital and see our expert team and Robin
Lachmann to receive the best dietary advise and support in
order to, treat their odour.
If you have any queries or
require any further information please do not hesitate to
Sue Edwards assistant
producer Betty - email@example.com
020 7907 0870
Conclusion - As no encouraging response was received
- it is reasonable to consider the very last thing
especially the Medical and Media personal desire, is someone
to come along and burst their bubble of Fifteen Minutes of
If I had to think is such a
manner I would most seriously have to consider my sanity of
being such a Psychotic Control freak as to only desire a
Person I work with to be deserved - if only but for the very
first time in their life; the Fundamental Right to be
educated in such a way as to be better in Mind and Body
Health - than their Tutor-therapist. Myself.
18: Where can we go to now?
18: They may be the possibility of late breaking
information we are able to use - however whilst we await its
arrival may we explore although not in any particular order,
some fragments gathered during my collection of information
relating to this disorder and in so doing start my appraisal
of the disorder.
May we start in a manner we intend to carry on:
May we dispel the name and all of its descriptions and any
Diet that could cure or even long-term manage as all they
are in reality information for the relief of the clinicians
anxiety only and nothing to do with
the Patient at all.
19: Trimethylamine is normally formed by bacterial
action in the intestine on choline - found in foods such as
soya, liver, kidneys, wheat germ, brewer’s yeast and egg
yolk? What does this mean?
Answer. 19: This is nonsense
- confirmed by - If one has no knowledge as to the chemical
activity in the Body as instructed by the Mind.
And, if we accept - Trimethylamine is indeed formed by
bacterial Action on another chemical Choline, then surely we
must see this is only part of a long-chain of chemical
events created by negative thoughts in the Mind, perhaps
many years prior to the onset of symptoms this chemical
activity is supposed to implicated; in the extreme Body
20: Where or why is this implicated in the disorder?
Trimethylamine N-oxide - as found in salt water fish.
20: One could with good reason consider it does not.
As the trimethylamine is then carried to the liver where it
is converted to trimethylamine N-oxide, a metabolic product
that has no odour.
21: When secondary Trimethylaminuria develops as a
result of large oral doses of L-carnitine, choline or
lecithin, the symptoms disappear as the dosage is lowered.
21: Strikes me this is a most serious attempt to
ensure the disorder is of biological creation and of
not even Novel let alone Scientific
22: L-carnitine is used in the treatment of
carnitine-deficiency syndromes and is sometimes used by
athletes who believe it enhances
22: A confirmation of answer 21. Body odour and
athletes physical strength are only related if one does not
have a clue what one is doing and indeed understands the
negative implication on a Patient this stupidity occasions.
23: It has been said - Choline is used in the
treatment of Huntington disease and Alzheimer's disease.
Does this have implications in the treatment of. TMAU?
23: Sure does like all treatments for the two
disorders you mention they only end in failure - thus as
they say all Roads lead to Rome.
24: Choline and lecithin are present in certain food
supplements and ‘health’ foods.
24: One may be pushed to ask. "What has this to do
with the price of Fish."
Surely if one has to turn to
so-called Health Foods it is an admittance Scientific
Medicine has not been successful in the resolution of
earlier presented symptoms - so how can this. As explained
in question and answer 19.
25: Trimethylaminuria - TMAU, as defined by the
consortium of endocrinology disorders as fish odour syndrome
or fish malodor syndrome, is a rare metabolic disorder that
causes a defect in the normal production of an enzyme named
flavin-containing monooxygenase 3 - FMO3.
25: It is only rare because Medical Science is the
only profession never once in real-terms to have improved
its product outcome of illness treatments - using the very
latest and best scientifically proven treatments.
26: When FMO3 is not working correctly or if not
enough enzyme is produced, the Body loses the ability to
properly convert trimethylamine (TMA) from precursor
compounds in food digestion into trimethylamine oxide
(TMAO), through a process called N-oxygenation. What does
this to equate to?
26: Nothing it is just a short section of the chain I
spoke of in answer 19 paragraph A. The clue is in the term.
27: Please explain the clue?
27: If the Body and the Blood is not properly
naturally Oxygenated - then as nothing will burn without
Oxygen then the Body is unable to burn its Fuel-Food in a
manner to allow comfortable Mind and Body activity. Thus
something is stopping this process and it is nothing to do
with the Diet.
28: How does that work when - The Trimethylamine
builds up and is released in the Person's sweat, urine and
breath, giving off a strong fishy odour or strong body
28: A variant of TMAU - secondary TMAU or TMAU2
exists where there is no genetic
cause, yet excessive TMA is secreted,
possibly due to intestinal
dysbiosis, altered metabolism, or
29: Tells me about it? Does not answer the question?
29: If one takes into consideration the items marked
in Red it is clear to see there is a lot of guesswork going
on - thus cannot be of any real value in understanding the
cause and in so doing create a cure for this most
30: But - Trimethylamine builds up in the Body of
Patients with Trimethylaminuria? Surely that is sufficient
to understand the disorder is real and not imagined or in
some ones HEAD?
30: The trimethylamine is released in the Person's
sweat, urine, reproductive fluids and breath, giving off a
strong fishy or Body odour.
But then so is Co2.
Carbon dioxide (CO2) is produced by all aerobic organisms
when they metabolize carbohydrate and lipids to produce
energy by respiration.
It is returned to water via the gills of fish and to the air
via the lungs of air-breathing land animals, including
Carbon dioxide is produced during the
processes of decay of organic materials and the
fermentation of sugars in bread, beer and wine making.
It is produced by combustion of wood, carbohydrates and
fossil fuels such as coal, peat, petroleum and natural gas.
Demonstrating why - Some People with Trimethylaminuria have
a strong odour all the time, but most have a moderate smell
that varies in intensity over time.
31: Why is it? The condition seems to be more common
in Women than Men?
31: Once again in true Scientific jargon the say with
scientific confidence "For unknown
reasons." Science suspects that female sex hormones,
such as progesterone and oestrogen, aggravate symptoms.
Question. 32: Are there any
indications as to what age a Child would be when first
presenting the symptoms?
32: There are several reports that the condition
worsens around puberty, thereby indicating it may have been
what they call Sub-Clinical for a long time.
Confirmed by there are a few reports of it being noticed in
extremely young Children.
33: What are the longer term implications as to its
progression or getting worse?
33: In Women it is reported, symptoms can worsen just
before and during menstrual periods,
after taking oral contraceptives and around menopause.
34: What are the real implications indicated in the
symptoms become worse "after taking
oral contraceptives and around menopause."
34: Whilst in this instance we have no knowledge as
to the age a Woman might be on entering or completing
cessation of menstruation.
May we for this instance accept the Woman is far too young
to complete this necessary process for all of her Body
functions to sustain through aging - a natural vibrancy.
Then we are able to see for much if not all of her lifetime
of menstruating her ability to sustain a natural or even as
a result of traumatic incidents in her life entire Body
And then ask; "how much of this process is implicated in the
worsening of the unpleasant Body odour symptoms.
35: What if anything are we able to make of; This
odour varies depending on many known factors, including
diet, hormonal changes, stress level, amount of sweat, other
odour's in the space and individual
sense of smell.
35: We the Clinical Teams are running out of ideas in
order for us to maintain the Moral and Scientific high
ground of knowing something of value - so we are preparing
for the final subliminal shove out of the door - and pay on
the way out please.
36: Justify that harsh statement please?
36: Of course a necessity if we are to improve the
knowledge base of this simple to understand multifaceted and
ever changing symptom presentation disorder.
Once this is stated; "stress level,"
"in the space and individual sense of smell." It is
now out of the available Medical Science where Stress level
is to close to the Mind so has to be ignored and In the
space and Individual Sense of Smell." Is a subliminal
suggestion of "It is all in your Head."
Leaving the Patient no option but to somewhat angrily stomp
out of the surgery and the clinician content it was not
their fault - it was the Patient who become angry and so was
37: Is there a value in a Diagnosis of TMAU?
37: Only if one is Scientifically Nose Blind - other
than that any Person Scientifically Qualified or not would
be able to detect - Extreme body odour politely or
impolitely referred to as. BO.
38: What if anything is the real value in testing -
38: Measurement of urine for the ratio of
trimethylamine to trimethylamine oxide is the standard
A blood test is available to
provide genetic analysis.
The prominent enzyme
responsible for TMA N-oxygenation is coded by the FMO3 gene.
False positives can occur in the following
conditions, where elevated TMA can be present in the urine
without any underlying TMAU.
Therefore in the Medical
Professions own words. "False Positives," how can anything
be truly be determined if these words are in one's
therapeutic vocabulary after so many years of study.
39: What about Urinary tract infections?
39: I would have to wonder if this term is used
something is seriously missing or there - as a result of
lack of satisfactory knowledge, a personal requirement to
avoid certain areas of the Female Body.
40: Are you able to be more specific than this?
40: Yes of course for Thirty Four plus years my
number one specialty in the treatment of People has been of
Far too many times - although this appears to be changing.
Females have explained to me. "Why is it
my Doctor even Female do not discuss as easily as you
regarding the delicate areas of my Body."
If treatment of any presenting symptom is unable to at least
incorporate this area into the discussions - then the
treatment will never be as successful as desired.
41: How can this be demonstrated and are you able to
bring this into the understanding required of TMAU?
41: Yes I can and very willing to do so.
Bacterial Vaginosis is a common yet poorly understood
condition, in which the balance of bacteria inside the
vagina becomes disrupted.
BV doesn't usually cause any vaginal soreness or itching,
but often causes unusual vaginal discharge.
Surely it must be seen if any Woman has these symptoms with
or not TMAU - then how can she adopt her rightful and
comfortable place in society.
Question. 42: Accepted and I
feel sure you will make more sense of this later? Are there
any other implications in this area of a Woman's Body we
42: Yes and this explains my comment in answer. 40 B.
Advanced liver Disease.
As the cause is not know and there is no known cure or
effective treatment for the TMAU; as with any illness
treated by symptom management only -
will result in not only those listed but many other
mysterious no known cause and no cure symptoms.
43: Is that last line what is referred to as. Tough
43: That is not so much as my intention more to
educate before the medical Profession collapses under it own
44: Does this in a hidden manner confirm your stance?
The metabolic and clinical manifestations of TMAU are
generally regarded as benign, as there is no associated
44: This designation is confirmed by the fact the
condition is often unrecognised by Doctors, thus can have
important ramifications including
missed or delayed diagnosis.
Or is the truth of it Doctors know this is a Mind created
disorder and are under strict instructions from their
Masters to ignore the Mind as there is no Profit to be made
in treating a disorder that cannot be seen and as the
knowledge of the Mind in 2016 is verily non existent.
They would not know if the treatment they have long-term
prescribed have created side-effects requiring - more profit
45: Where then do you stand on this statement?
"Trimethylaminuria - fish malodour syndrome is a “benign,”
genetic condition with major
45: It is Scientifically Proven NONSENSE, for these
Sequelae is a pathological condition resulting from a
disease, injury, therapy, or other trauma.
Typically, a sequelae is, in
medical language, a chronic condition that is
a complication of an
acute condition that begins
during that acute condition.
In ordinary language; it may be described as a
further condition that is
different from, but a consequence of
the first condition.
In timing a sequelae contrasts with a late effect, where
there is a period, sometimes as long as several decades,
between the resolution of the initial condition and the
appearance of the late effect.
46: Love the last part - there we have it in Medical
Science own words they make People through lack of secure
knowledge as to how the Mind and Body interrelate in illness
are making People more ill by their efforts.
46: Sadly is the truth of it.
47: Is there any public information emanating for
respected Medical Journals?
47: It appears there is albeit very aged and very
repetitive of what has always been not known and still today
is no different.
One Medical Journal as far back as October 2008 appears to
confirm and in part contradict others aged information.
Affected individuals experience shame and embarrassment,
fail to maintain relationships, avoid contact with People
who comment on their condition and are obsessive about
masking the odour with hygiene products and even smoking.
The malodorous aspect can have serious and destructive
effects on schooling, personal life, career and
relationships, resulting in social isolation, low
self-esteem, depression, paranoid behaviour and suicide.
Psychosocial problems resulting from delayed diagnosis, body
odour and the lack of cure
are considerable, making this far
from a “benign” disorder.
When the condition is suspected or known to occur in a
family, genetic testing can be helpful in identifying the
specific individuals who have or carry the disorder.
"Trimethylaminuria - fish malodour syndrome: a “benign”
genetic condition with major psychosocial sequelae."
Sequelae is a pathological condition resulting from a
disease, injury, therapy, or other trauma.
Typically, a sequelae is, in medical language, a chronic
condition that is a complication of an acute condition that
begins during that acute condition.
In ordinary language it may be described as a further
condition that is different from, but a consequence of, the
In timing - a sequelae contrasts with a late effect, where
there is a period, sometimes as long as several decades,
between the resolution of the initial condition and the
appearance of the late effect.
Ways of reducing the fishy odour may include:
Avoiding foods such as egg yolks, legumes, red meats, fish,
beans and other foods that contain choline, carnitine,
nitrogen, sulphur and lecithin.
Taking low doses of antibiotics such as neomycin and
metronidazole in order to reduce the amount of bacteria in
Using slightly acidic detergent with a pH between 5.5 and
Additionally, at least one study has suggested that daily
intake of the supplements activated charcoal and copper
chlorophyllin may improve the quality of life of individuals
afflicted with TMAU by helping their bodies to oxidize and
convert TMA to the odourless N-oxide (TMAO) metabolite.
Study participants experienced
subjective reduction in odour as well as objective
reduction in TMA and increase in TMAO concentration measured
in their urine.
Objective. Pertaining to or
characteristic of an individual; Personal; Individual: a
Subjective. Is explained as -Existing in the Mind;
belonging to the thinking subject rather than to the object
Cures demonstrates. Very few Humans are able to be
Objective and Subjective at the
same time - although this as a Fundamental Right is
activated or returned as a result of effective; cause
The study found that: 85% of test participants experienced
complete loss of detectable "fishy" odour, 10% experienced
some reduction in detectable odour. And 5% did not
experience any detectable odour reduction.
Talking Cures observed; It appears no explanation was sought
or demonstrated as to why this disparity occurred.
48: Is there a value of revisiting the Genetic aspect
of this disorder?
48: Good point I do have a collection of Genetic
information which is only a repeat of information we have
already questioned - however that is how medical science is
so often presented; having said that let us say it anyway to
ensure we have at least explored all the information which
is of a world wide limited nature.
Trimethylaminuria has an autosomal recessive pattern of
Most cases of Trimethylaminuria appear to be inherited in an
autosomal recessive pattern, which means two copies of the
gene in each cell are altered.
The Parents of an individual with an autosomal recessive
disorder are carriers of one copy of the altered gene.
Carriers may have mild symptoms of Trimethylaminuria or
experience temporary episodes of fish-like body odour.
Mutations in the FMO3 gene, which is found on the long arm
of chromosome 1, cause Trimethylaminuria.
The FMO3 gene makes an enzyme that breaks down
nitrogen-containing compounds from the diet, including
These compounds are produced by bacteria in the intestine as
they digest proteins from eggs, meat, soy, and other foods.
Normally, the FMO3 enzyme converts fishy-smelling
trimethylamine into trimethylamine N-oxide which has no
If the enzyme is missing or its activity is reduced because
of a mutation in the FMO3 gene, trimethylamine is not broken
down and instead builds up in the Body.
As the compound is released in a Person's sweat, urine and
breath, it causes the strong odour characteristic of
There are more than 40 known mutations associated
Loss-of-function mutations, nonsense mutations and missense
mutations are three of the most common.
Missense mutation is a point mutation in which a
single nucleotide change results in a codon which is a
sequence of three DNA or RNA nucleotides that corresponds
with a specific amino acid or stop signal during protein
synthesis. that codes for a different amino acid.
It is a type of nonsynonymous substitution.
Nonsynonymous mutations have a much greater affect on
an individual than a synonymous mutation.
In a nonsynonymous mutation, there is usually an
insertion or deletion of a single nucleotide in the sequence
during transcription when the messenger RNA is copying the
This single missing or added nucleotide causes a frame shift
mutation which throws off the entire reading frame of the
amino acid sequence and mixes up the codons.
This usually does affect the amino acids that are
coded for and change the resulting protein that is
The severity of this kind of mutation depends on how
early in the amino acid sequence it happens.
If it happens near the beginning and the entire protein is
changed, this could become a lethal mutation.
Another way a nonsynonymous mutation can occur is if the
point mutation changes the single nucleotide into a codon
that does not translate into the same amino acid.
A lot of times, the single amino acid change does not
affect the protein very much and is still viable.
However, if it happens early in the sequence and the codon
is changed to translate into a stop signal, then the protein
will not be made and it could cause serious consequences.
Sometimes nonsynonymous mutations are actually positive
Natural selection may favour this new expression of
the gene and the individual may have developed a favorable
adaptation from the mutation.
If that mutation occurs in the gametes, this adaptation will
be passed down to the next generation of offspring.
Nonsynonymous mutations increase the diversity in the gene
pool for natural selection to work on and drive evolution on
a microevolutionary level.
Nonsense and missense mutations cause the most severe
Although FMO3 mutations account for most known cases
of Trimethylaminuria, some cases are caused by other
A fish-like body odour could result from an excess of
certain proteins in the diet or from an increase in bacteria
in the digestive system.
A few cases of the disorder have been identified in
adults with liver damage caused by hepatitis.
In 2007 the evolution of the FMO3 gene was studied,
including the evolution of some mutations associated with
49: Having observed the contradictions and in their
own word and making much missense within question 48
subsections 1.31. In simple terms are you able to make some
sense of it all?
49: Yes it clearly Nonsense made clear by;
Researchers believe that stress and
diet also play a role in triggering symptoms.
And; Individuals with this
condition who do not have any physical symptoms - typically
A Scientifically proven
dismissal if ever there is one.
50: You spoke earlier in your answer 18 of late
breaking information is this transpired or are we still
50: Sadly nothing yet. I was hoping we would have a
collaborator to make the discussion more of a confirmation
of opinions rather than a discussion between just Medical
Science and myself.
51: Is that a suggestion of a Person with the
disorder collaborating with their input.
51: Yes indeed.
52: Whilst we wait may we have your opinion as to the
true cause of this disorder?
52: Opinion is correct when we consider. Re: 18. B.
May we dispel the name and all of its descriptions and any
Diet that could cure or even long-term manage - as all they
are in reality information for the relief of the clinicians
anxiety only and nothing to do with
the Patient at all.
Based on the secure
Scientific understanding of the disorder; If Scientifically
the cause is not known and there is no known cure, has one
earned the right to give it a name.
53: Where you to be given the opportunity of giving
this disorder a name - what if anything would you call it?
53: Good question. The same as any disorder or
condition of course recognising we have to have a reference
point to work with.
Un natural Body Odour, would seem to suffice.
if nothing else would put those around the Person with the
disorder on notice to just respect the Person is
experiencing difficult time and requires all the support
they themselves may desire if they had concerns - that defy
the understanding of Medical Science.
54: Nice - not sure where - 53.2 came from but is
worthy of anyone's support?
Are we ready to explain the aetiology - posh word for real
cause, of this disorder now?
TMAU Trimethylaminuria the
54: Statistics from the world appear to demonstrate
there are some 7 billion People in the world.
Medical Science through its extensive Genetic studies -
demonstrate every one of us is unique even siblings born of
the same Parents.
There are we are also informed small number of exceptions to
this - with, identical twins.
May we create in the fashion
we started with a numbered order from creation to symptoms
with no known cause and no known cure.
From answer 54, A and B. It is clear why Medial
Science is unable to make sense of the symptom presentation
- as it is unique to each Person; so diagnosed.
Not to be considered the absolute cause - However the Entire
Body Chemistry of the affected Person's Parents - based on
their negative emotional history are a very serious
Parents do not have to have or ever had the presenting
symptoms, to comply with this.
The Child's perception to a traumatic incident whilst within
the womb, is a serious contender but not a guarantee.
The same applies during the birthing process.
From birth any one or all of these place a Child in
This brings the Child into the world with a sensitive
The sensitivity is not a concern indeed it can lead a
Child to great life achievements if left to its own devices.
However if at anytime during the Child's formative years -
up to the age of Twenty one or When the Child leaves the
Parental Home what ever came first - traumas could make what
may well have been a positive sensitivity - into being
This irreversibly alters the Entire Body Chemistry and is
not biologically changeable.
This process places a Person on a life-long quest to
gather understanding for the original - sensitivity creating
Initially from the People deemed responsible; not ever to be
If we may call item 10 a seed - given time and the
correct negative nurturing and any or many, ever changing
mysterious symptoms will evolve.
In order to bring this into an understandable
situation - we are all aware of the scent spraying/marking
of an animal marking out its territory in order to protect
its family and feeding ground.
With this to hand it is somewhat easier to consider - when a
Person is unable to keep themselves fresh as a fundamental
right, not a gift.
It is a deep seated subconscious Mind desire as a protection
to maintain a position of safety.
Demonstrated by - as People so often find. NO-One will come
near them or desire to form a relationship with them because
they Smell Fishy.
Or is it the other way around.
Of course as we started there are as many causes as there
are People with or not the disorder in question.
Are we able to accept as painful as it must surely be - with
this in Mind perhaps comes the explanation why no amount of
Biological Testing or Management Treatments will offer
long-term resolution of the ever-changing symptoms; if the
originating cause is not - or has not been resolved.
Kindest regards and best
Peter Smith Talking Cures.
55. Are we to understand the
collaborator we spoke of in question 51 has not and is not
able to do so?
Answer. 55. Sadly this is so,
of course we must respect the Person's situation as well as
it is a fundament right not a gift to have the choice and
not be forced into a compromising situation.
being the very process that gave the Person the concern in
the very first instance - leaving an unknown driving force
"Do not take my illness away from me I will not know what to
do without it - nor be able to Protect myself from those
well wishers that only do me harm."
This is my truth now tell me
yours - change someone's Mind.
illness - The Mind/Brain/Body is not in the slightest doing
something wrong, it is desperately trying to right a serious
and terrible wrong?
"No apologies are made if
this paper is seen as repeating or simplistic, for too long
Scientific Medical Papers have been written in a manner no
one truly understands, if this were not so, cures would have
long since been found making this paper and Talking Cures
unnecessary or redundant.
Whilst it must be
recognised, the framework - part of the content, for this
paper is in the public domain and credit given to the
Smith Talking Cures asserts the right to be recognised as
author and Intellectual
©Copyright holder of his
contribution to this document."
Explored Understood Explained." Author Peter Smith Talking
Cures Copyright 26th April 2016.
Thus, in keeping with the
generosity of many contributors - this document is free to
use as an Education or Patient led assistance - in its